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Synthesis of Spiroisoxazolines by 1,3-Dipolar Cycloaddition
- Peter Micuch,
- Lubor Fisera,
- Vladimír Ondrus and
- Peter Ertl
The cycloaddition of the chiral nitrile oxide 1 to 1-R-substituted 3,3-methylene-5,5-dimethyl-2-pyrrolidinones 2 (where R is H, n-butyl-, 1,1-dimethylethoxycarbonyl-, 1-methylethenyl- and acetyl-) proceeds regioselectively under the formation of spir...

