General Anesthesia-Related Drop in Diastolic Blood Pressure May Impact the Long-Term Outcome in Stroke Patients Undergoing Thrombectomy
Abstract
:1. Introduction
2. Methods
2.1. Study Design and Population
2.2. Anesthesia Protocol
2.3. Data Collection and Outcome Measures
2.4. Statistical Analysis
3. Results
4. Discussion
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Acknowledgments
Conflicts of Interest
References
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General Anesthesia n = 82 (41%) | Conscious Sedation n = 117 (59%) | p-Value | |
---|---|---|---|
Demographics | |||
Age, y | 83 ± 18 | 58 ± 15 | 0.183 |
Male, n (%) | 34 (41.5%) | 56 (47.9%) | 0.791 |
BMI | 27 ± 6 (n = 48) | 27.2 ± 5 (n = 78) | 0.448 |
Comorbidities n (%) | |||
Atrial fibrillation, n (%) | 35/82 (42.7%) | 48/106 (45.3%) | 0.759 |
Diabetes mellitus, n (%) | 20/75 (26.7%) | 30/106 (28.3%) | 0.808 |
Clinical presentation | |||
IVT before EVT | 31/82 (37.8%) | 35/117 (29.9%) | 0.245 |
NIHSS before thrombectomy, | 14 (IQR: 11–18) (n = 60) | 11 (IQR:7–16) (n = 103) | 0.009 |
NIHSS after thrombectomy | 10.5 (IQR 5–15) (n = 70) | 7 (IQR 2–12) (n = 107) | 0.008 |
NIHSS at 24 h after onset | 9 (IQR: 5–14) (n = 73) | 6 (IQR: 1–12) (n = 111) | 0.029 |
ASPECTS | 7.8 ± 0.9 (n = 39) | 8.1 ± 1.0 (n = 60) | 0.294 |
Outcome | |||
In-hospital death, n (%) | 16/82 (19.5%) | 15/117 (12.8%) | 0.200 |
Good outcome 30 days (mRS 0–2) | 30/72 (41.7%) | 56/104 (53.8%) | 0.143 |
Good outcome 90 days (mRS 0–2) | 34/69 (49.3%) | 60/100 (60%) | 0.146 |
Time metrics, minutes | |||
Onset to recanalization, min | 377 ± 144 (n = 39) | 333 ± 199 (n = 45) | 0.260 |
Door to recanalization, min | 80 ± 36 (n = 45) | 61 ± 20 (n = 53) | 0.004 |
30-Day Favorable Outcome | ||||
Variables | B | Odds Ratio | 95% CI | p-Value |
age | −0.031 | 0.969 | 0.94–1.00 | 0.050 |
sex | 0.022 | 1.023 | 0.49–2.10 | 0.951 |
NIHSS at 24 h | −0.077 | 0.926 | 0.88–0.97 | 0.004 |
type of anesthesia | −0.423 | 0.655 | 0.31–1.37 | 0.259 |
DBPmin | −0.022 | 0.978 | 0.95–1.01 | 0.174 |
DBPdiff | −0.027 | 0.973 | 0.94–1.01 | 0.107 |
90-Day Favorable Outcome | ||||
age | −0.023 | 0.977 | 0.95–1.01 | 0.152 |
sex | −0.002 | 0.998 | 0.48–2.06 | 0.995 |
NIHSS at 24 h | −0.068 | 0.934 | 0.89–0.98 | 0.008 |
type of anesthesia | −0.218 | 0.804 | 0.38–1.69 | 0.566 |
DBPmin | −0.018 | 0.982 | 0.95–1.01 | 0.263 |
DBPdiff | −0.039 | 0.961 | 0.93–0.99 | 0.024 |
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Abada, A.; Csecsei, P.; Ezer, E.; Lenzser, G.; Hegyi, P.; Szolics, A.; Merei, A.; Szentesi, A.; Molnar, T. General Anesthesia-Related Drop in Diastolic Blood Pressure May Impact the Long-Term Outcome in Stroke Patients Undergoing Thrombectomy. J. Clin. Med. 2022, 11, 2997. https://doi.org/10.3390/jcm11112997
Abada A, Csecsei P, Ezer E, Lenzser G, Hegyi P, Szolics A, Merei A, Szentesi A, Molnar T. General Anesthesia-Related Drop in Diastolic Blood Pressure May Impact the Long-Term Outcome in Stroke Patients Undergoing Thrombectomy. Journal of Clinical Medicine. 2022; 11(11):2997. https://doi.org/10.3390/jcm11112997
Chicago/Turabian StyleAbada, Alan, Peter Csecsei, Erzsebet Ezer, Gabor Lenzser, Peter Hegyi, Alex Szolics, Akos Merei, Andrea Szentesi, and Tihamer Molnar. 2022. "General Anesthesia-Related Drop in Diastolic Blood Pressure May Impact the Long-Term Outcome in Stroke Patients Undergoing Thrombectomy" Journal of Clinical Medicine 11, no. 11: 2997. https://doi.org/10.3390/jcm11112997
APA StyleAbada, A., Csecsei, P., Ezer, E., Lenzser, G., Hegyi, P., Szolics, A., Merei, A., Szentesi, A., & Molnar, T. (2022). General Anesthesia-Related Drop in Diastolic Blood Pressure May Impact the Long-Term Outcome in Stroke Patients Undergoing Thrombectomy. Journal of Clinical Medicine, 11(11), 2997. https://doi.org/10.3390/jcm11112997