Kinases and GTPases in Cancer: The Role of Mutations and sRNAs

Dear Colleagues,

Kinases and GTPases are central regulators of cellular signaling, and their dysregulation is a hallmark of cancer. This Topic explores two primary mechanisms driving oncogenesis: direct genetic mutations and post-transcriptional modulation by small non-coding RNAs (sRNAs). Activating mutations in GTPases (such as KRAS) or upstream kinases frequently lock these proteins in a constitutively active state, leading to uncontrolled proliferation, survival, and metastasis. Concurrently, sRNAs—including microRNAs (miRNAs) and small interfering RNAs (siRNAs)—play a dual role by either suppressing or promoting tumor progression. These molecules can modulate the expression of kinases and GTPases, creating complex regulatory loops that influence drug resistance and metastatic potential. Understanding the interplay between mutational activation and sRNA-mediated regulation is critical for deciphering cancer heterogeneity. Ultimately, this integrated view highlights novel diagnostic biomarkers and therapeutic opportunities, such as mutant-specific inhibitors or RNA-based strategies aimed at restoring normal signaling network homeostasis.

Dr. Jonas Cicenas
Prof. Dr. Lee M. Graves
Topic Editors