Druggable Targets in Human Diseases and Therapeutic Target Identification for Bioactive Natural Products

Dear Colleagues,

In the era of precision medicine, elucidation of drug targets has emerged as the principal drivers of innovative therapeutic development. Concurrently, natural products offer a rich repository of novel molecular entities for targeted therapies, leveraging their inherent chemical diversity and multi-target regulatory advantages. Nevertheless, efficient screening of bioactive constituents from complex natural products, coupled with accurate elucidation of their molecular targets and mechanisms, remains a formidable challenge.

This Topic “Druggable Targets in Human Diseases and Therapeutic Target Identification for Bioactive Natural Products,” seeks to assemble cutting-edge research spanning the isolation and structural elucidation of bioactive natural products, target profiling strategy, and comprehensive pharmacodynamic validation. Contributions unveiling novel small-molecule targets in diseases and include natural small molecule validation work are equally welcome.

We invite high-quality submissions that integrate innovative technologies with robust experimental validation to drive forward the next generation of natural product-based targeted therapeutics.

Dr. Jun Dang
Prof. Dr. Gang Li
Topic Editors