Marine-Derived Bioactive Components in the Prevention and Treatment of Memory Disorders

Dear Colleagues,

The life expectancy of the global population is on the rise, leading to a corresponding increase in the prevalence of memory disorders each year, including age-related memory impairment, mild cognitive impairment, and memory deficits associated with neurodegenerative diseases such as Alzheimer's disease. This trend places a significant economic and social burden on society, as individuals with memory disorders often experience a decline in quality of life and require long-term care and intervention to maintain daily functioning. The challenge lies in the fact that existing interventions for memory disorders have not yet translated into clinical applications that can effectively enhance memory function, prevent memory decline, or reverse memory impairment without adverse effects. While basic research has provided insights into the molecular mechanisms involved in memory formation, consolidation, and deterioration—such as synaptic plasticity, neuroinflammation, oxidative stress, and neurotransmitter imbalance—these discoveries have not yet translated into new pharmacological treatments that can significantly improve memory outcomes. Interestingly, the marine ecosystem is a rich and untapped source of diverse bioactive components, including marine polysaccharides, peptides, polyunsaturated fatty acids, terpenoids, and phenolics, which have demonstrated promising biological activities related to memory regulation in preclinical studies.

This Topic aims to explore the potential role of marine-derived bioactive components in the prevention and treatment of memory disorders. We welcome original research articles, systematic reviews, meta-analyses, and perspective papers focusing on the isolation, identification, and pharmacological evaluation of marine bioactive components, as well as combined therapies with supplements or lifestyle in enhancing memory function, improving memory deficits, and preventing memory decline associated with various memory disorders.

Dr. Zhiyou Yang
Prof. Dr. Yi Zhang
Topic Editors