Synthesis and Application of 1,2,3-Triazole Derivatives
A special issue of Molecules (ISSN 1420-3049). This special issue belongs to the section "Organic Chemistry".
Deadline for manuscript submissions: 31 March 2026 | Viewed by 470
Special Issue Editors
Interests: 1,2,3-triazole; heterocycle; cyclization; C-H bond activation; coupling reaction
Special Issue Information
Dear Colleagues,
1,2,3-triazole derivatives represent a privileged class of nitrogen-containing heterocycles with immense significance across diverse scientific disciplines. Their synthesis has been revolutionized by the advent of click chemistry, particularly the highly efficient, regioselective, and modular copper(I)-catalyzed azide–alkyne cycloaddition (CuAAC) reaction founded by Sharpless and Meldal Groups at the beginning of this century, allowing for rapid generation of extensive libraries of structurally diverse derivatives. The unique structural features of the triazole ring—including stability under physiological conditions, hydrogen bonding capability, dipole moment, and robust aromatic character—contribute to its remarkable versatility. Consequently, 1,2,3-triazole derivatives exhibit a wide spectrum of biological activities, driving extensive exploration in pharmaceutical chemistry as potent antimicrobials, anticancer agents, antivirals, anti-inflammatory agents, and CNS modulators. Beyond medicinal chemistry, these compounds find crucial applications as agrochemicals, corrosion inhibitors for metals, fluorescent sensors and probes, ligands in catalysis, and building blocks for functional polymers and advanced materials. Moreover, 1,2,3-triazole derivatives play remarkable roles in organic synthesis, participating in both ring-retaining and ring-opening processes.
This Special Issue invites original papers and reviews focusing on 1,2,3-triazoles, including their original synthesis, direct modifications, transannulative transformations, and applications in various fields.
Prof. Dr. Yubo Jiang
Guest Editor
Dr. Guiping Qin
Guest Editor Assistant
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Keywords
- 1,2,3-triazoles
- synthesis
- modification
- transannulation
- application
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