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19 Results Found

  • Article
  • Open Access
2,305 Views
11 Pages

Advances in Virtual Cutting Guide and Stereotactic Navigation for Complex Tumor Resections of the Sacrum and Pelvis: Case Series with Short-Term Follow-Up

  • Takashi Hirase,
  • Grant R. McChesney,
  • Lawrence Garvin,
  • Karthik Tappa,
  • Robert L. Satcher,
  • Alexander F. Mericli,
  • Laurence D. Rhines and
  • Justin E. Bird

Primary malignancies of the sacrum and pelvis are aggressive in nature, and achieving negative margins is essential for preventing recurrence and improving survival after en bloc resections. However, these are particularly challenging interventions d...

  • Review
  • Open Access
13 Citations
13,247 Views
21 Pages

Current Concepts in the Treatment of Giant Cell Tumor of Bone: An Update

  • Shinji Tsukamoto,
  • Andreas F. Mavrogenis,
  • Tomoya Masunaga,
  • Kanya Honoki,
  • Hiromasa Fujii,
  • Akira Kido,
  • Yasuhito Tanaka and
  • Costantino Errani

8 April 2024

Curettage is recommended for the treatment of Campanacci stages 1–2 giant cell tumor of bone (GCTB) in the extremities, pelvis, sacrum, and spine, without preoperative denosumab treatment. In the distal femur, bone chips and plate fixation are...

  • Review
  • Open Access
16 Citations
4,944 Views
12 Pages

Current Concepts in the Resection of Bone Tumors Using a Patient-Specific Three-Dimensional Printed Cutting Guide

  • Hisaki Aiba,
  • Benedetta Spazzoli,
  • Shinji Tsukamoto,
  • Andreas F. Mavrogenis,
  • Tomas Hermann,
  • Hiroaki Kimura,
  • Hideki Murakami,
  • Davide Maria Donati and
  • Costantino Errani

29 March 2023

Orthopedic oncology has begun to use three-dimensional-printing technology, which is expected to improve the accuracy of osteotomies, ensure a safe margin, and facilitate precise surgery. However, several difficulties should be considered. Cadaver an...

  • Article
  • Open Access
9 Citations
3,688 Views
24 Pages

Surgical and Oncologic Outcome following Sacrectomy for Primary Malignant Bone Tumors and Locally Recurrent Rectal Cancer

  • Anne Weidlich,
  • Klaus-Dieter Schaser,
  • Jürgen Weitz,
  • Johanna Kirchberg,
  • Johannes Fritzmann,
  • Christian Reeps,
  • Philipp Schwabe,
  • Ingo Melcher,
  • Alexander Disch and
  • Hagen Fritzsche
  • + 3 authors

26 June 2024

Introduction: Bone sarcoma or direct pelvic carcinoma invasion of the sacrum represent indications for partial or total sacrectomy. The aim was to describe the oncosurgical management and complication profile and to analyze our own outcome results fo...

  • Article
  • Open Access
2 Citations
1,128 Views
13 Pages

The Association of Gender in the Management and Prognosis of Vertebral and Sacral Chordoma: A SEER Analysis

  • Aladine A. Elsamadicy,
  • Sumaiya Sayeed,
  • Josiah J. Z. Sherman,
  • Paul Serrato,
  • Shaila D. Ghanekar,
  • Sheng-Fu Larry Lo and
  • Daniel M. Sciubba

4 March 2025

Background/Objectives: Chordomas are rare primary osseous tumors of the spine and skull base that may portend significant morbidity and mortality. Gender disparities in the management and outcomes of spinal and pelvic chordomas have been sparsely stu...

  • Case Report
  • Open Access
1 Citations
1,844 Views
5 Pages

16 July 2024

Schwannomas are benign and slow-growing peripheral nerve sheath neoplasms of Schwann cells. These are generally encountered in the neck, head, and flexor areas of the extremities. Even though many schwannomas are easily diagnosable, their variable mo...

  • Article
  • Open Access
29 Citations
3,995 Views
19 Pages

3D-Printed Titanium Custom-Made Prostheses in Reconstruction after Pelvic Tumor Resection: Indications and Results in a Series of 14 Patients at 42 Months of Average Follow-Up

  • Carmine Zoccali,
  • Jacopo Baldi,
  • Dario Attala,
  • Alessandra Scotto di Uccio,
  • Luca Cannavò,
  • Gennaro Scotto and
  • Alessandro Luzzati

12 August 2021

Wide resection is currently considered the mainstay treatment for primary bone tumors. When the tumor is located in anatomically complex segments, 3D-Printed Titanium Custom-Made Prostheses (3DPTCMP) are possible reconstructive solutions. The aim of...

  • Article
  • Open Access
6 Citations
3,334 Views
15 Pages

The Importance of the Hedgehog Signaling Pathway in Tumorigenesis of Spinal and Cranial Chordoma

  • Reza Akhavan-Sigari,
  • Walter Schulz-Schaeffer,
  • Amanda Angelika Harcej and
  • Veit Rohde

15 February 2019

Chordomas is rare malignant bone tumors thought to arise from remnants of embryonic notochord along the spine, frequently at the skull base and sacrum. Although chordoma is slow growing tumors, while are extremely recurrent, and aggressive, as well a...

  • Case Report
  • Open Access
12 Citations
1 Views
3 Pages

Osteoblastoma of the Jaws: Report of a Case and Review of Literature

  • Bhari Sharanesha Manjunatha,
  • Patel Sunit,
  • Mahajan Amit and
  • Shah Sanjiv

21 November 2011

Benign osteoblastoma (OB) is a rare tumor of bone representing less than 1% of all tumors of the maxillofacial region. Vertebral column, sacrum, long bones, and calvarium are more frequent sites of this tumor. Clinically, patients present with pain a...

  • Article
  • Open Access
8 Citations
2,737 Views
12 Pages

Custom-Made 3D-Printed Implants for Anterior Column Reconstruction in the Upper Cervical Spine after Intralesional Extracapsular Excision—Report of 2 Cases and Literature Review

  • Marco Girolami,
  • Cristiana Griffoni,
  • Emanuela Asunis,
  • Luigi Falzetti,
  • Stefano Bandiera,
  • Giovanni Barbanti Brodano,
  • Riccardo Ghermandi,
  • Valerio Pipola,
  • Silvia Terzi and
  • Alessandro Gasbarrini
  • + 6 authors

13 October 2022

The use of three-dimensional (3D)-printed custom-made implants is spreading in the orthopedics field for the reconstruction of bone losses or for joint replacement, thanks to their unparalleled versatility. In particular, this novel technology opens...

  • Article
  • Open Access
1,451 Views
16 Pages

Malignant Giant Cell Tumor of Bone: A Study of Clinical, Pathological, and Prognostic Profile from One Single Center

  • Jingtian Shi,
  • Xin Sun,
  • Jichuan Wang,
  • Haijie Liang,
  • Xingyu Liu,
  • Yi Yang,
  • Xiaodong Tang and
  • Wei Guo

Malignant giant cell tumor of bone (GCTB) is a rare malignant bone tumor. This analysis was conducted on patients with malignant GCTB at our center. The clinical, demographic, and prognostic characteristics were evaluated and compared. During 1 Janua...

  • Review
  • Open Access
1 Citations
2,330 Views
22 Pages

Multidisciplinary En-Bloc Resection of Sacral Chordoma: A Narrative Review and Illustrative Case

  • Daniel Kiss-Bodolay,
  • Frederic Ris,
  • Adrien Lavalley,
  • Aria Nouri,
  • Carlo M. Oranges,
  • Guillaume Meurette,
  • Karl Schaller,
  • Enrico Tessitore and
  • Granit Molliqaj

24 June 2025

Background/Objectives: Sacral chordomas are rare, locally invasive tumors that pose significant surgical and oncological challenges due to their anatomical complexity, proximity to critical structures, and resistance to conventional therapies. Method...

  • Article
  • Open Access
4 Citations
3,220 Views
7 Pages

Interobserver Reliability and the Sigmoid Takeoff—An Interobserver Study

  • Malene Roland Vils Pedersen,
  • Peter Obel Otto,
  • Chris Vagn-Hansen,
  • Torben Sørensen and
  • Søren Rafael Rafaelsen

4 June 2022

Background: Colorectal cancer is the second most common cancer worldwide. The sigmoid takeoff is the landmark where the colon sigmoid curves toward the sacrum viewed from sagittal magnetic resonance imaging (MRI). The purpose of this study was to ass...

  • Review
  • Open Access
91 Citations
10,335 Views
18 Pages

Chordoma—Current Understanding and Modern Treatment Paradigms

  • Sean M. Barber,
  • Saeed S. Sadrameli,
  • Jonathan J. Lee,
  • Jared S. Fridley,
  • Bin S. Teh,
  • Adetokunbo A. Oyelese,
  • Albert E. Telfeian and
  • Ziya L. Gokaslan

4 March 2021

Chordoma is a low-grade notochordal tumor of the skull base, mobile spine and sacrum which behaves malignantly and confers a poor prognosis despite indolent growth patterns. These tumors often present late in the disease course, tend to encapsulate a...

  • Article
  • Open Access
1,287 Views
13 Pages

Recurrence Patterns After Resection of Sacral Chordoma: Toward an Optimized Postoperative Target Volume Definition

  • Hanna Waldsperger,
  • Burkhard Lehner,
  • Andreas Geisbuesch,
  • Felix Jotzo,
  • Eva Meixner,
  • Laila König,
  • Sebastian Regnery,
  • Katharina Kozyra,
  • Lars Wessel and
  • Katharina Seidensaal
  • + 3 authors

30 July 2025

Background: Postoperative recurrence of sacrococcygeal chordomas presents significant clinical challenges due to unusual recurrence patterns. This study aimed to characterize these patterns of recurrence to inform improved adjuvant radiotherapy plann...

  • Technical Note
  • Open Access
1 Citations
1,378 Views
9 Pages

Lumbopelvic Fixation: How to Be Less Invasive When You Cannot Be Minimally Invasive—A New Subcutaneous Supra-Fascial Approach to Minimize Open Iliac Screwing

  • Carlo Brembilla,
  • Emanuele Stucchi,
  • Mario De Robertis,
  • Giorgio Cracchiolo,
  • Ali Baram,
  • Gabriele Capo,
  • Zefferino Rossini,
  • Andrea Franzini,
  • Marco Riva and
  • Maurizio Fornari
  • + 1 author

27 February 2025

Background/Objectives: Lumbopelvic fixation (LPF) is essential for stabilizing the lumbosacral junction (LSJ) in cases of trauma, tumors, and other pathologies. While minimally invasive percutaneous techniques are preferred when feasible, open LPF re...

  • Review
  • Open Access
18 Citations
6,488 Views
18 Pages

Chordoma: A Comprehensive Systematic Review of Clinical Trials

  • Sonja Chen,
  • Ruben Ulloa,
  • Justin Soffer,
  • Roberto J. Alcazar-Felix,
  • Carl H. Snyderman,
  • Paul A. Gardner,
  • Vijay A. Patel and
  • Sean P. Polster

11 December 2023

This systematic review aims to characterize ongoing clinical trials and therapeutic treatment options for chordoma, a rare notochordal remnant tumor that primarily affects the cranial base, mobile spine, and sacrum. While radical surgical resection r...

  • Article
  • Open Access
19 Citations
3,694 Views
17 Pages

Trends in Tumor Site-Specific Survival of Bone Sarcomas from 1980 to 2018: A Surveillance, Epidemiology and End Results-Based Study

  • Xianglin Hu,
  • Kai Deng,
  • Hui Ye,
  • Zhengwang Sun,
  • Wending Huang,
  • Yangbai Sun and
  • Wangjun Yan

27 October 2021

Objectives: As diagnosis and treatment guidelines for bone sarcomas continue updating, it is important to examine whether, when, and which kinds of patients have had a survival improvement over the last four decades. Methods: This cohort study includ...

  • Article
  • Open Access
12 Citations
3,988 Views
9 Pages

Spinal Manifestation of Malignant Primary (PLB) and Secondary Bone Lymphoma (SLB)

  • Melanie Barz,
  • Kaywan Aftahy,
  • Insa Janssen,
  • Yu-Mi Ryang,
  • Georg Prokop,
  • Stephanie E. Combs,
  • Philipp J. Jost,
  • Bernhard Meyer and
  • Jens Gempt

2 October 2021

Manifestation of malignant lymphoma in the spine is rare; there have only been a few cases reported in the literature. Due to its rarity, there is no gold standard for the management of patients suffering from spinal lymphoma manifestations. Methods:...