Inherited cancer susceptibility and tumor microevolution concern different levels of cancer biology. This critical narrative review examines their connections in gastric, colorectal, hepatocellular, biliary tract and pancreatic cancers. We organize t...
The role of lactic acid (lactate) in cell metabolism has been significantly revised in recent decades. Initially, lactic acid was attributed to the role of a toxic end-product of metabolism, with its accumulation in the cell and extracellular space l...
Cancer development follows an evolutionary pattern of “mutation-selection-adaptation” detailed by Cancer Evolution and Development (Cancer Evo-Dev), a theory that represents a process of accumulating somatic mutations due to the imbalance...
Highly dynamic epigenetic signaling is influenced mainly by (micro)environmental stimuli and genetic factors. The exact mechanisms affecting particular epigenomic patterns differ dependently on the context. In the current review, we focus on the caus...
Metronomic agents reduce the effective doses and adverse effects of cytostatics in cancer chemotherapy. Therefore, they can enhance the treatment efficiency of drug-resistant cancers. Cytostatic and anti-angiogenic effects of fenofibrate (FF) suggest...
Background and Objectives: Changes in the environment and physiology may be associated with an increased or decreased risk of cancer. Our study aims to evaluate the strength and the direction of the selection acting on oncosuppressor genes in associa...