4 Results Found

Advanced Search

Select all

Results per page

Select all

Article

1 Citations

1,895 Views

30 Pages

Expanding the Knowledge of the Molecular Effects and Therapeutic Potential of Incomptine A for the Treatment of Non-Hodgkin Lymphoma: In Vivo and Bioinformatics Studies, Part III

Normand García-Hernández,
Fernando Calzada,
Elihú Bautista,
José Manuel Sánchez-López and ,
Miguel Valdes,
Claudia Velázquez and
Elizabeth Barbosa
+ 2 authors+ 0 author

Pharmaceuticals2025, 18(9), 1263;https://doi.org/10.3390/ph18091263

25 August 2025

Background/Objectives: Non-Hodgkin lymphoma (NHL) is a group of blood cancers that arise in the lymphatic nodes and other tissues after an injury to the DNA of B/T lineage and NK lymphocytes. Recently, we reported that incomptine A (IA) has in vivo a...

(This article belongs to the Special Issue Biomedical Properties, Developments and Therapeutic Potential of Sesquiterpenoid Lactones and Natural Compounds)

Full Article

Article

12 Citations

5,106 Views

22 Pages

Safety Implications of Modulating Nuclear Receptors: A Comprehensive Analysis from Non-Clinical and Clinical Perspectives

Mohan Rao,
Eric McDuffie,
Sanjay Srivastava,
Warren Plaisted and
Clifford Sachs

Pharmaceuticals2024, 17(7), 875;https://doi.org/10.3390/ph17070875

3 July 2024

The unintended modulation of nuclear receptor (NR) activity by drugs can lead to toxicities amongst the endocrine, gastrointestinal, hepatic cardiovascular, and central nervous systems. While secondary pharmacology screening assays include NRs, safet...

(This article belongs to the Section Pharmacology)

Full Article

Article

10 Citations

5,251 Views

13 Pages

Chemoinformatic Analysis of Selected Cacalolides from Psacalium decompositum (A. Gray) H. Rob. & Brettell and Psacalium peltatum (Kunth) Cass. and Their Effects on FcεRI-Dependent Degranulation in Mast Cells

Jorge Iván Castillo-Arellano,
Juan Carlos Gómez-Verjan,
Nadia A. Rojano-Vilchis,
Myrna Mendoza-Cruz and ,
Manuel Jiménez-Estrada,
Héctor E. López-Valdés,
Hilda Martínez-Coria,
Roger Gutiérrez-Juárez,
Claudia González-Espinosa and
Isabel Arrieta-Cruz
+ 6 authors+ 1 author

Molecules2018, 23(12), 3367;https://doi.org/10.3390/molecules23123367

19 December 2018

Cacalolides are a kind of sesquiterpenoids natural compounds synthesized by Psacalium decompositum (A. Gray) H. Rob. & Brettell or Psacalium peltatum (Kunth) Cass. Antioxidant and hypoglycemic effects have been found for cacalolides such as cacal...

(This article belongs to the Special Issue Biological Activities of Plant Secondary Metabolites)

Full Article

Article

3 Citations

4,406 Views

18 Pages

Efflux Pump-Binding 4(3-Aminocyclobutyl)Pyrimidin-2-Amines Are Colloidal Aggregators

Tania Szal,
Shweta Singh Chauhan,
Philipp Lewe,
Fatima-Zahra Rachad and ,
Marina Madre,
Laura Paunina,
Susanne Witt,
Ramakrishnan Parthasarathi and
Björn Windshügel
+ 4 authors+ 0 author

Biomolecules2023, 13(6), 1000;https://doi.org/10.3390/biom13061000

16 June 2023

Efflux pumps are a relevant factor in antimicrobial resistance. In E. coli, the tripartite efflux pump AcrAB-TolC removes a chemically diverse set of antibiotics from the bacterium. Therefore, small molecules interfering with efflux pump function are...

(This article belongs to the Section Molecular Biophysics: Structure, Dynamics, and Function)

Full Article