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12 Results Found

  • Article
  • Open Access
8 Citations
5,477 Views
16 Pages

Targeted Treatment Options of Recurrent Radioactive Iodine Refractory Hürthle Cell Cancer

  • Mehtap Derya Aydemirli,
  • Willem Corver,
  • Ruben Beuk,
  • Paul Roepman,
  • Nienke Solleveld-Westerink,
  • Tom van Wezel,
  • Ellen Kapiteijn and
  • Hans Morreau

15 August 2019

Objective: To evaluate the efficacy and treatment rationale of Hürthle cell carcinoma (HCC) following a patient with progressive and metastatic HCC. HCC was recently shown to harbor a distinct genetic make-up and the mitogen-activated protein ki...

  • Article
  • Open Access
17 Citations
4,045 Views
27 Pages

A Million-Cow Genome-Wide Association Study of Three Fertility Traits in U.S. Holstein Cows

  • Zuoxiang Liang,
  • Dzianis Prakapenka,
  • Paul M. VanRaden,
  • Jicai Jiang,
  • Li Ma and
  • Yang Da

A genome-wide association study (GWAS) of the daughter pregnancy rate (DPR), cow conception rate (CCR), and heifer conception rate (HCR) using 1,001,374–1,194,736 first-lactation Holstein cows and 75,140–75,295 SNPs identified 7567, 3798,...

  • Communication
  • Open Access
11 Citations
2,975 Views
12 Pages

A genome-wide association study (GWAS) of age at first calving (AFC) using 813,114 first lactation Holstein cows and 75,524 SNPs identified 2063 additive effects and 29 dominance effects with p-values < 10−8. Three chromosomes had highly sig...

  • Article
  • Open Access
11 Citations
2,745 Views
13 Pages

Identification of Soybean Yield QTL in Irrigated and Rain-Fed Environments

  • Geung-Joo Lee,
  • Sungwoo Lee,
  • Tommy E. Carter,
  • Grover Shannon and
  • H. Roger Boerma

30 October 2021

Drought is the primary abiotic stress that limits yield of soybean (Glycine max (L.) Merr.). The study aimed to identify yield-related quantitative trait loci (QTLs) in soybeans using a population of 160 F4-derived lines from ‘Hutcheson’ × PI 471938...

  • Article
  • Open Access
13 Citations
5,028 Views
18 Pages

19 November 2019

Leaf premature senescence largely determines maize (Zea mays L.) grain yield and quality. A natural recessive premature-senescence mutant was selected from the breeding population, and near-isogenic lines were constructed using Jing24 as the recurren...

  • Article
  • Open Access
10 Citations
7,711 Views
9 Pages

MIA3 Splice Defect in Cane Corso Dogs with Dental-Skeletal-Retinal Anomaly (DSRA)

  • Matthias Christen,
  • Henriëtte Booij-Vrieling,
  • Jelena Oksa-Minalto,
  • Cynthia de Vries,
  • Alexandra Kehl,
  • Vidhya Jagannathan and
  • Tosso Leeb

25 September 2021

We investigated a hereditary syndrome in Cane Corso dogs. Affected dogs developed dental-skeletal-retinal anomaly (DSRA), clinically characterized by brittle, discolored, translucent teeth, disproportionate growth and progressive retinal degeneration...

  • Article
  • Open Access
29 Citations
4,975 Views
11 Pages

18 October 2021

Rice black-streaked dwarf disease, caused by rice black-streaked dwarf virus (RBSDV), is a serious constraint in Chinese rice production. Breeding disease-resistant varieties through multigene aggregation is considered an effective way to control dis...

  • Article
  • Open Access
3 Citations
3,003 Views
19 Pages

23 February 2021

A wheat 660K chip was used to genotype two wheat-Dasypyrum villosum 6V#4S.6DL and 6V#2S.6AL translocation lines (A303 and B303) and their common wheat recurrent parent Wan7107. The results showed that these three lines have similar characteristics of...

  • Article
  • Open Access
3 Citations
2,616 Views
13 Pages

Identification of Two Novel Loci Underlying Tolerance to Clavibacter michiganensis Originating from Solanum arcanum LA2157

  • Eleni Koseoglou,
  • Matthijs Brouwer,
  • Derek Mudadirwa,
  • Jan M. Van der Wolf,
  • Richard G. F. Visser and
  • Yuling Bai

23 March 2023

Clavibacter michiganensis (Cm) is a tomato phytopathogenic bacterium. Outbreaks of Cm can result in severe yield and economic losses. To date, no resistance to Cm has been identified. Screening of wild tomato accessions has resulted in the identifica...

  • Article
  • Open Access
606 Views
16 Pages

Genome-Wide Identification of GW5-LIKE Family Revealed the Function of ClGL1 Involved in Fruit and Seed Shape by Mediating Brassinosteroid Signaling in Watermelon

  • Peng Tian,
  • Lei Zhang,
  • Jingjing Zhang,
  • Bowen Liu,
  • Wei Liu,
  • Bing Li,
  • Xiurui Gao,
  • Jie Zhang,
  • Yanrong Wu and
  • Yong Xu

The regulatory mechanism of brassinolide (BR) signaling in cucurbitaceae crops remains incompletely understood. Previous research demonstrated that the rice genes GW5 and GW5L modulate seed morphology via the BR pathway. However, the conservation of...

  • Review
  • Open Access
87 Views
20 Pages

The Diagnostic and Prognostic Role of Combined p16 and MTAP Immunohistochemistry in Melanocytic Tumors of Uncertain Malignant Potential: A Comprehensive Review and Clinical Practice Analysis

  • Ludovica Pepe,
  • Vincenzo Fiorentino,
  • Cristina Pizzimenti,
  • Maurizio Martini,
  • Mariacarmela Santarpia,
  • Antonina Fazio,
  • Mario Vaccaro,
  • Maria Lentini and
  • Antonio Ieni

Melanocytic Tumors of Uncertain Malignant Potential (MELTUMPs) remain among the most challenging entities in dermatopathology due to overlapping morphologic features and marked inter-observer variability. This comprehensive review critically assesses...

  • Article
  • Open Access
23 Citations
3,477 Views
13 Pages

Improvement of Stable Restorer Lines for Blast Resistance through Functional Marker in Rice (Oryza sativa L.)

  • Jegadeesan Ramalingam,
  • Savitha Palanisamy,
  • Ganesh Alagarasan,
  • Vellaichamy Gandhimeyyan Renganathan,
  • Ayyasamy Ramanathan and
  • Ramasamy Saraswathi

27 October 2020

Two popular stable restorer lines, CB 87 R and CB 174 R, were improved for blast resistance through marker-assisted back-cross breeding (MABB). The hybrid rice development program in South India extensively depends on these two restorer lines. Howeve...