You are currently viewing a new version of our website. To view the old version click .

11 Results Found

  • Article
  • Open Access
2 Citations
2,883 Views
24 Pages

Impact of Microdosimetric Modeling on Computation of Relative Biological Effectiveness for Carbon Ion Radiotherapy

  • Shannon Hartzell,
  • Keith M. Furutani,
  • Alessio Parisi,
  • Tatsuhiko Sato,
  • Yuki Kase,
  • Christian Deglow,
  • Thomas Friedrich and
  • Chris J. Beltran

Microdosimetry plays a critical role in particle therapy by quantifying energy deposition within microscopic domains to assess biological effects. This study evaluates the influence of different microdosimetric functions (MFs) and domain geometries (...

  • Article
  • Open Access
4 Citations
3,297 Views
23 Pages

30 December 2024

Ion radiotherapy requires accurate relative biological effectiveness (RBE) calculations to account for the markedly different biological effects of ions compared to photons. Microdosimetric RBE models rely on descriptions of the energy deposition at...

  • Article
  • Open Access
1 Citations
2,277 Views
10 Pages

Evaluation of Helium Ion Radiotherapy in Combination with Gemcitabine in Pancreatic Cancer In Vitro

  • Bahar Cepni,
  • Thomas Tessonnier,
  • Ivana Dokic,
  • Stephan Brons,
  • Bouchra Tawk,
  • Andrea Mairani,
  • Amir Abdollahi,
  • Jürgen Debus,
  • Klaus Herfarth and
  • Jakob Liermann

14 April 2024

Background: Pancreatic cancer is one of the most aggressive and lethal cancers. New treatment strategies are highly warranted. Particle radiotherapy could offer a way to overcome the radioresistant nature of pancreatic cancer because of its biologica...

  • Article
  • Open Access
6 Citations
3,345 Views
14 Pages

23 August 2020

The Microdosimetric Kinetic Model (MKM) to predict the effects of ionizing radiation on cell colonies is studied and reformulated for the case of high-linear energy transfer (LET) radiations with a low dose. When the number of radiation events happen...

  • Article
  • Open Access
20 Citations
3,810 Views
25 Pages

A Hybrid Deep Learning Model Using CNN and K-Mean Clustering for Energy Efficient Modelling in Mobile EdgeIoT

  • Dhananjay Bisen,
  • Umesh Kumar Lilhore,
  • Poongodi Manoharan,
  • Fadl Dahan,
  • Olfa Mzoughi,
  • Fahima Hajjej,
  • Praneet Saurabh and
  • Kaamran Raahemifar

In mobile edge computing (MEC), it is difficult to recognise an optimum solution that can perform in limited energy by selecting the best communication path and components. This research proposed a hybrid model for energy-efficient cluster formation...

  • Article
  • Open Access
1,564 Views
19 Pages

2 April 2025

The increasing demand for sustainable road infrastructure necessitates alternative materials that enhance soil stabilization while reducing environmental impact. This study investigated the application of organosilane-based nanotechnology to improve...

  • Article
  • Open Access
11 Citations
2,098 Views
19 Pages

Planning Strategy to Optimize the Dose-Averaged LET Distribution in Large Pelvic Sarcomas/Chordomas Treated with Carbon-Ion Radiotherapy

  • Ankita Nachankar,
  • Mansure Schafasand,
  • Antonio Carlino,
  • Eugen Hug,
  • Markus Stock,
  • Joanna Góra and
  • Piero Fossati

9 October 2023

To improve outcomes in large sarcomas/chordomas treated with CIRT, there has been recent interest in LET optimization. We evaluated 22 pelvic sarcoma/chordoma patients treated with CIRT [large: HD-CTV ≥ 250 cm3 (n = 9), small: HD-CTV < 250 cm3...

  • Article
  • Open Access
7 Citations
2,667 Views
19 Pages

Sacral-Nerve-Sparing Planning Strategy in Pelvic Sarcomas/Chordomas Treated with Carbon-Ion Radiotherapy

  • Ankita Nachankar,
  • Mansure Schafasand,
  • Eugen Hug,
  • Giovanna Martino,
  • Joanna Góra,
  • Antonio Carlino,
  • Markus Stock and
  • Piero Fossati

26 March 2024

To minimize radiation-induced lumbosacral neuropathy (RILSN), we employed sacral-nerve-sparing optimized carbon-ion therapy strategy (SNSo-CIRT) in treating 35 patients with pelvic sarcomas/chordomas. Plans were optimized using Local Effect Model-I (...

  • Review
  • Open Access
53 Citations
10,827 Views
17 Pages

A Quasi-Mechanistic Mathematical Representation for Blood Viscosity

  • Samuel J. Hund,
  • Marina V. Kameneva and
  • James F. Antaki

1 March 2017

Blood viscosity is a crucial element for any computation of flow fields in the vasculature or blood-wetted devices. Although blood is comprised of multiple elements, and its viscosity can vary widely depending on several factors, in practical applica...

  • Article
  • Open Access
20 Citations
2,404 Views
21 Pages

This research is based on computing the new wave packets and conserved quantities to the nonlinear low-pass electrical transmission lines (NLETLs) via the group-theoretic method. By using the group-theoretic technique, we analyse the NLETLs and compu...

  • Article
  • Open Access
7 Citations
3,609 Views
18 Pages

Exploring Helium Ions’ Potential for Post-Mastectomy Left-Sided Breast Cancer Radiotherapy

  • Santa Gabriella Bonaccorsi,
  • Thomas Tessonnier,
  • Line Hoeltgen,
  • Eva Meixner,
  • Semi Harrabi,
  • Juliane Hörner-Rieber,
  • Thomas Haberer,
  • Amir Abdollahi,
  • Jürgen Debus and
  • Andrea Mairani

18 January 2024

Proton therapy presents a promising modality for treating left-sided breast cancer due to its unique dose distribution. Helium ions provide increased conformality thanks to a reduced lateral scattering. Consequently, the potential clinical benefit of...