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Article

30 Citations

5,130 Views

17 Pages

High Levels of the Cleaved Form of Galectin-9 and Osteopontin in the Plasma Are Associated with Inflammatory Markers That Reflect the Severity of COVID-19 Pneumonia

Gaowa Bai,
Daisuke Furushima,
Toshiro Niki,
Takashi Matsuba,
Yosuke Maeda,
Atsushi Takahashi,
Toshio Hattori and
Yugo Ashino

Int. J. Mol. Sci.2021, 22(9), 4978;https://doi.org/10.3390/ijms22094978

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7 May 2021

Numbers of patients with coronavirus disease 2019 (COVID-19) have increased rapidly worldwide. Plasma levels of full-length galectin-9 (FL-Gal9) and osteopontin (FL-OPN) as well as their truncated forms (Tr-Gal9, Ud-OPN, respectively), are representa...

Review

24 Citations

5,146 Views

28 Pages

Both Full-Length and Protease-Cleaved Products of Osteopontin Are Elevated in Infectious Diseases

Toshio Hattori,
Hiroko Iwasaki-Hozumi,
Gaowa Bai,
Haorile Chagan-Yasutan,
Ashwnini Shete,
Elizabeth Freda Telan,
Atsushi Takahashi,
Yugo Ashino and
Takashi Matsuba

Biomedicines2021, 9(8), 1006;https://doi.org/10.3390/biomedicines9081006

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13 August 2021

Circulating full-length osteopontin (FL-OPN) is elevated in plasma from patients with various infectious diseases, such as adult T-cell leukemia, Mycobacterium tuberculosis (TB), hepatitis virus infection, leptospirosis, acquired immune deficiency sy...

Article

10 Citations

3,027 Views

13 Pages

Naturally Occurring N-Terminal Fragments of Bovine Milk Osteopontin Are Transported across Models of the Intestinal Barrier

Brian Christensen,
Nanna R. Nielsen,
Marie R. Sørensen,
Lotte N. Jacobsen,
Marie S. Ostenfeld and
Esben S. Sørensen

Biomedicines2023, 11(3), 893;https://doi.org/10.3390/biomedicines11030893

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14 March 2023

Osteopontin (OPN) is a bioactive integrin-binding protein found in high concentrations in milk, where it is present both as a full-length protein and as several N-terminally derived fragments. OPN resists gastric digestion, and via interaction with r...

Review

14 Citations

4,319 Views

36 Pages

Thrombin Cleavage of Osteopontin and the Host Anti-Tumor Immune Response

Lawrence L. Leung,
Timothy Myles and
John Morser

Cancers2023, 15(13), 3480;https://doi.org/10.3390/cancers15133480

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3 July 2023

Osteopontin (OPN) is a multi-functional protein that is involved in various cellular processes such as cell adhesion, migration, and signaling. There is a single conserved thrombin cleavage site in OPN that, when cleaved, yields two fragments with di...

Article

15 Citations

7,786 Views

11 Pages

Stimulation of THP-1 Macrophages with LPS Increased the Production of Osteopontin-Encapsulating Exosome

Gaowa Bai,
Takashi Matsuba,
Toshiro Niki and
Toshio Hattori

Int. J. Mol. Sci.2020, 21(22), 8490;https://doi.org/10.3390/ijms21228490

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11 November 2020

Osteopontin (OPN) mediates bone remodeling and tissue debridement. The OPN protein is cleaved, but it is unclear how full-length (FL)-OPN or its cleaved form perform their biological activities in target cells. We, therefore, performed the molecular...

Review

40 Citations

6,606 Views

20 Pages

Osteopontin as a Biomarker in Chronic Kidney Disease

Satyesh K. Sinha,
Michael Mellody,
Maria Beatriz Carpio,
Robert Damoiseaux and
Susanne B. Nicholas

Biomedicines2023, 11(5), 1356;https://doi.org/10.3390/biomedicines11051356

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4 May 2023

Osteopontin (OPN) is a ubiquitously expressed protein with a wide range of physiological functions, including roles in bone mineralization, immune regulation, and wound healing. OPN has been implicated in the pathogenesis of several forms of chronic...

Article

1 Citations

1,869 Views

15 Pages

The Association of Anti-Sm with Osteopontin Related to Cognitive Impairment in a Pristane-Induced Lupus BALB/c Mice Model

Daniel González-Inostroz,
Flavio Sandoval-García,
Fernanda-Isadora Corona-Meraz,
Mónica Vázquez Del Mercado,
Jorge Guzmán-Muñiz,
Milton Omar Guzmán-Ornelas,
Rolando Castañeda-Arellano,
Jacinto Bañuelos-Pineda,
Miguel Peña-Nava and
Beatriz-Teresita Martín-Márquez

Int. J. Mol. Sci.2024, 25(23), 13080;https://doi.org/10.3390/ijms252313080

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5 December 2024

The BALB/c model of pristane-induced lupus (PIL) exhibits cognitive impairment features resembling neuropsychiatric lupus (NPLSE). Osteopontin (OPN) is associated with disease activity in SLE; however, its involvement in NPLSE is not yet entirely det...

Article

12 Citations

5,610 Views

11 Pages

Synthesis of a Cleaved Form of Osteopontin by THP-1 Cells and Its Alteration by Phorbol 12-Myristate 13-Acetate and BCG Infection

Gaowa Bai,
Hirotoshi Motoda,
Ryo Ozuru,
Haorile Chagan-Yasutan,
Toshio Hattori and
Takashi Matsuba

Int. J. Mol. Sci.2018, 19(2), 418;https://doi.org/10.3390/ijms19020418

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31 January 2018

The protease-cleaved osteopontin (OPN) was proposed to enhance the migration of memory T cells to granulomas in tuberculosis. Various forms of OPN were identified in human monocytic THP-1 cells stimulated by phorbol 12-myristate 13-acetate (PMA). Ant...

Article

2 Citations

2,552 Views

11 Pages

Association of SARS-CoV-2 Seropositivity with Persistent Immune Activation in HIV/Tuberculosis Co-Infected Patients

Ashwini Shete,
Manisha Ghate,
Hiroko Iwasaki-Hozumi,
Sandip Patil,
Pallavi Shidhaye,
Takashi Matsuba,
Gaowa Bai,
Pratiksha Pharande and
Toshio Hattori

Reports2024, 7(3), 61;https://doi.org/10.3390/reports7030061

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29 July 2024

We asked if SARS-CoV-2 seropositivity in HIV/TB co-infected patients plays a role in precipitating active tuberculosis in HIV-infected individuals and alters inflammatory status. A prospective study was conducted on HIV/TB co-infected patients presen...

Article

1 Citations

981 Views

17 Pages

Increased Plasma Levels of Thrombin-Cleaved Osteopontin in Patients with Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage

Kazuaki Aoki,
Fumihiro Kawakita,
Koichi Hakozaki,
Hideki Kanamaru,
Reona Asada,
Hidenori Suzuki and
pSEED Group

Int. J. Mol. Sci.2025, 26(6), 2781;https://doi.org/10.3390/ijms26062781

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19 March 2025

Osteopontin (OPN), a matricellular protein, is produced as a full-length OPN (FL-OPN) and cleaved by thrombin, thus generating the N-terminal half of OPN (OPN N-half) with new functions. Although plasma FL-OPN levels have been associated with neurova...

Article

14 Citations

3,761 Views

13 Pages

Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis

Haorile Chagan-Yasutan,
Firmanto Hanan,
Toshiro Niki,
Gaowa Bai,
Yugo Ashino,
Shinichi Egawa,
Elizabeth Freda O. Telan and
Toshio Hattori

Diagnostics2020, 10(7), 439;https://doi.org/10.3390/diagnostics10070439

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29 June 2020

: Leptospirosis becomes severe, with a fatality rate of >10%, and manifests as severe lung injury accompanied by acute kidney injury. Using urine and blood samples of 112 patients with leptospirosis, osteopontin (OPN), galectin-9 (Gal-9) and other...

Article

18 Citations

4,244 Views

15 Pages

Plasma Levels of a Cleaved Form of Galectin-9 Are the Most Sensitive Biomarkers of Acquired Immune Deficiency Syndrome and Tuberculosis Coinfection

Shirley T. Padilla,
Toshiro Niki,
Daisuke Furushima,
Gaowa Bai,
Haorile Chagan-Yasutan,
Elizabeth Freda Telan,
Rosario Jessica Tactacan-Abrenica,
Yosuke Maeda,
Rontgene Solante and
Toshio Hattori

Biomolecules2020, 10(11), 1495;https://doi.org/10.3390/biom10111495

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30 October 2020

Acquired immunodeficiency syndrome (AIDS) complicated with tuberculosis (TB) is a global public issue. Due to the paucity of bacteria in AIDS/TB, blood-based biomarkers that reflect disease severity are desired. Plasma levels of matricellular protein...

Article

21 Citations

4,465 Views

14 Pages

The Impact of Glycosylation of Osteopontin on Urinary Stone Formation

Go Anan,
Tohru Yoneyama,
Daisuke Noro,
Yuki Tobisawa,
Shingo Hatakeyama,
Mihoko Sutoh Yoneyama,
Hayato Yamamoto,
Atsushi Imai,
Hiromichi Iwamura and
Yuki Kohada
+ 7 authors

Int. J. Mol. Sci.2020, 21(1), 93;https://doi.org/10.3390/ijms21010093

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21 December 2019

Osteopontin (OPN) is a matrix glycoprotein of urinary calculi. This study aims to identify the role of aberrant glycosylation of OPN in urolithiasis. We retrospectively measured urinary glycosylated OPN normalized by urinary full-length-OPN levels in...

Article

2 Citations

2,042 Views

16 Pages

Dynamics of Matricellular Protein Levels in Blood Predict Recovery in Patients with Human Immunodeficiency Virus-Tuberculosis Coinfection

Ashwini Shete,
Manisha Ghate,
Hiroko Iwasaki-Hozumi,
Sandip Patil,
Pallavi Shidhaye,
Gaowa Bai,
Takashi Matsuba,
Pratiksha Pharande,
Bharati Mahajan and
Aarti Randive
+ 2 authors

Viruses2024, 16(5), 664;https://doi.org/10.3390/v16050664

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24 April 2024

Chronic immune activation in tuberculosis (TB) associated with human immunodeficiency virus (HIV) infection (HIV/TB) modifies their clinical course. We prospectively measured osteopontin (OPN), full-length galectin-9 (FL-Gal9), and total-Gal9 (T-Gal9...

Article

6 Citations

3,353 Views

11 Pages

Vitamin D3 Repletion Improves Vascular Function, as Measured by Cardiorenal Biomarkers in a High-Risk African American Cohort

Satyesh K. Sinha,
Ling Sun,
Michelle Didero,
David Martins,
Keith C. Norris,
Jae Eun Lee,
Yuan-Xiang Meng,
Jung Hye Sung,
Michael Sayre and
Maria Beatriz Carpio
+ 1 author

Nutrients2022, 14(16), 3331;https://doi.org/10.3390/nu14163331

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14 August 2022

Background: 25-hydroxy vitamin D (Vit D)-deficiency is common among patients with chronic kidney disease (CKD) and contributes to cardiovascular disease (CVD). African Americans (AAs) suffer disproportionately from CKD and CVD, and 80% of AAs are Vit...