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Open AccessArticle

Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis

1
Department of Health Science and Social Welfare, Kibi International University, 8 Igamachi, Takahashi 716-8508, Japan
2
Mongolian Psychosomatic Medicine Department, International Mongolian Medicine Hospital of Inner Mongolia, Hohhot 010065, China
3
Disease Control and Prevention Division of Banyuasin District Health Office, Pangkalan Balai, South Sumatra 30753, Indonesia
4
Department of Immunology, Faculty of Medicine, Kagawa University, Kita-gun 761-0793, Japan
5
Department of Respiratory Medicine, Sendai City Hospital, Miyagi 982-8502, Japan
6
International Research Institute of Disaster Science, Tohoku University, Sendai 980-8575, Japan
7
National Reference Laboratory for HIV/AIDS, Hepatitis, and other STDs, STD/AIDS Cooperative Central Laboratory, Manila 1003, Philippines
*
Author to whom correspondence should be addressed.
Diagnostics 2020, 10(7), 439; https://doi.org/10.3390/diagnostics10070439
Received: 1 June 2020 / Revised: 20 June 2020 / Accepted: 25 June 2020 / Published: 29 June 2020
(This article belongs to the Section Pathology and Molecular Diagnostics)
: Leptospirosis becomes severe, with a fatality rate of >10%, and manifests as severe lung injury accompanied by acute kidney injury. Using urine and blood samples of 112 patients with leptospirosis, osteopontin (OPN), galectin-9 (Gal-9) and other kidney-related biomarkers were measured to understand the pathological and diagnostic roles of OPN and Gal-9 in leptospirosis. Plasma levels of full-length (FL)-OPN (pFL-OPN) (p < 0.0001), pFL-Gal-9(p < 0.0001) and thrombin-cleaved OPN (p < 0.01) were significantly higher in patients with leptospirosis than in healthy controls (n = 30), as were levels of several indicators of renal toxicity: serum cystatin C (p < 0.0001), urine N-acetyl-β-glucosaminidase (NAG)/creatinine (p < 0.05), and urine clusterin/creatinine (p < 0.05). pFL-Gal-9 levels were negatively correlated with pFL-OPN levels (r = −0.24, p < 0.05). pFL-OPN levels were positively correlated with serum cystatin C (r = 0.41, p < 0.0001), urine NAG/creatinine (r = 0.35, p < 0.001), urine clusterin/creatinine (r = 0.33, p < 0.01), and urine cystatin C/creatinine (r = 0.33, p < 0.05) levels. In a group of patients with abnormally high creatinine levels, significantly higher levels of serum cystatin C (p < 0.0001) and pFL-OPN (p < 0.001) were observed. Our results demonstrate that pFL-OPN reflect kidney injury among patients with leptospirosis. View Full-Text
Keywords: leptospirosis; biomarker; osteopontin; galectin-9; cystatin C; clusterin; creatinine leptospirosis; biomarker; osteopontin; galectin-9; cystatin C; clusterin; creatinine
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Chagan-Yasutan, H.; Hanan, F.; Niki, T.; Bai, G.; Ashino, Y.; Egawa, S.; Telan, E.F.O.; Hattori, T. Plasma Osteopontin Levels is Associated with Biochemical Markers of Kidney Injury in Patients with Leptospirosis. Diagnostics 2020, 10, 439.

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