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Article

9 Citations

3,036 Views

12 Pages

Circulating Levels of Dephosphorylated-Uncarboxylated Matrix Gla Protein in Patients with Acute Coronary Syndrome

Admira Bilalic,
Tina Ticinovic Kurir,
Marko Kumric,
Josip A. Borovac,
Andrija Matetic,
Daniela Supe-Domic and
Josko Bozic

Molecules2021, 26(4), 1108;https://doi.org/10.3390/molecules26041108

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19 February 2021

Vascular calcification contributes to the pathogenesis of coronary artery disease while matrix Gla protein (MGP) was recently identified as a potent inhibitor of vascular calcification. MGP fractions, such as dephosphorylated-uncarboxylated MGP (dp-u...

Article

2,565 Views

11 Pages

Association of Dephosphorylated-Uncarboxylated Matrix Gla Protein and Risk of Major Bleeding in Patients Presenting with Acute Myocardial Infarction

Admira Bilalic,
Tina Ticinovic Kurir,
Josip A. Borovac,
Marko Kumric,
Daniela Supe-Domic,
Marino Vilovic,
Dinko Martinovic and
Josko Bozic

Life2021, 11(8), 733;https://doi.org/10.3390/life11080733

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23 July 2021

The “Can Rapid risk stratification of Unstable angina patients Suppress ADverse outcomes with Early implementation of the ACC/AHA guidelines” (CRUSADE) score emerged as a predictor of major bleeding in patients presenting with the acute coronary synd...

Article

8 Citations

2,653 Views

13 Pages

Plasma Dephosphorylated-Uncarboxylated Matrix Gla-Protein in Systemic Sclerosis Patients: Biomarker Potential for Vascular Calcification and Inflammation

Judith Potjewijd,
Rachid Tobal,
Karin A. Boomars,
Vanessa V. P. M. van Empel,
Femke de Vries,
Jan G. M. C. Damoiseaux,
Leon J. Schurgers and
Pieter van Paassen

Diagnostics2023, 13(23), 3526;https://doi.org/10.3390/diagnostics13233526

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24 November 2023

Background: Systemic sclerosis (SSc) patients face an elevated risk of cardiovascular disease (CVD), even when classic cardiovascular risk factors are considered. Plasma dephosphorylated-uncarboxylated Matrix Gla-protein (dp-ucMGP), an inactive form...

Article

32 Citations

4,067 Views

13 Pages

The Association of dp-ucMGP with Cardiovascular Morbidity and Decreased Renal Function in Diabetic Chronic Kidney Disease

Stefanos Roumeliotis,
Athanasios Roumeliotis,
Aikaterini Stamou,
Konstantinos Leivaditis,
Konstantia Kantartzi,
Stylianos Panagoutsos and
Vassilios Liakopoulos

Int. J. Mol. Sci.2020, 21(17), 6035;https://doi.org/10.3390/ijms21176035

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21 August 2020

We aimed to investigate the possible association of the inactive, dephosphorylated, uncarboxylated matrix Gla protein (dp-ucMGP) with oxidized low-density lipoprotein (ox-LDL) and all-cause/cardiovascular (CV) mortality and renal function in diabetic...

Article

6 Citations

2,158 Views

14 Pages

The Roles of Vitamin D Levels, Gla-Rich Protein (GRP) and Matrix Gla Protein (MGP), and Inflammatory Markers in Predicting Mortality in Intensive Care Patients: A New Biomarker Link?

Fatih Seğmen,
Semih Aydemir,
Onur Küçük and
Recep Dokuyucu

Metabolites2024, 14(11), 620;https://doi.org/10.3390/metabo14110620

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13 November 2024

Objectives: Identifying reliable biomarkers to predict mortality in critically ill patients is crucial for optimizing management in intensive care units (ICUs). Inflammatory and metabolic markers are increasingly recognized for their prognostic value...

Review

107 Citations

15,928 Views

27 Pages

Association of the Inactive Circulating Matrix Gla Protein with Vitamin K Intake, Calcification, Mortality, and Cardiovascular Disease: A Review

Stefanos Roumeliotis,
Evangelia Dounousi,
Theodoros Eleftheriadis and
Vassilios Liakopoulos

Int. J. Mol. Sci.2019, 20(3), 628;https://doi.org/10.3390/ijms20030628

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1 February 2019

Matrix Gla Protein (MGP), a small Gla vitamin K-dependent protein, is the most powerful natural occurring inhibitor of calcification in the human body. To become biologically active, MGP must undergo vitamin K-dependent carboxylation and phosphorylat...

Review

8 Citations

4,481 Views

13 Pages

Role of Matrix Gla Protein in the Complex Network of Coronary Artery Disease: A Comprehensive Review

Marko Kumric,
Josip A. Borovac,
Tina Ticinovic Kurir,
Dinko Martinovic,
Ivan Frka Separovic,
Ljupka Baric and
Josko Bozic

Life2021, 11(8), 737;https://doi.org/10.3390/life11080737

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24 July 2021

Coronary artery disease (CAD) is widely recognized as one of the most important clinical entities. In recent years, a large body of accumulated data suggest that coronary artery calcification, a process highly prevalent in patients with CAD, occurs v...

Review

26 Citations

6,948 Views

14 Pages

Vitamin K Supplementation for Prevention of Vascular Calcification in Chronic Kidney Disease Patients: Are We There Yet?

Stefanos Roumeliotis,
Anila Duni,
Vasilios Vaios,
Athanasios Kitsos,
Vassilios Liakopoulos and
Evangelia Dounousi

Nutrients2022, 14(5), 925;https://doi.org/10.3390/nu14050925

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22 February 2022

Chronic Kidney Disease (CKD) patients are at high risk of presenting with arterial calcification or stiffness, which confers increased cardiovascular mortality and morbidity. In recent years, it has become evident that VC is an active process regulat...

Article

12 Citations

3,617 Views

15 Pages

Association of Red Blood Cell Distribution Width and Neutrophil-to-Lymphocyte Ratio with Calcification and Cardiovascular Markers in Chronic Kidney Disease

Stefanos Roumeliotis,
Ioannis E. Neofytou,
Cecile Maassen,
Petra Lux,
Konstantia Kantartzi,
Evangelos Papachristou,
Leon J. Schurgers and
Vassilios Liakopoulos

Metabolites2023, 13(2), 303;https://doi.org/10.3390/metabo13020303

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17 February 2023

We aimed to investigate the association between Red Blood Cell Distribution Width (RDW) and Neutrophil-to-Lymphocyte Ratio (NLR), simple, rapidly assessed markers from the complete blood count with vascular calcification (VC)/stiffness and cardiovasc...

Review

44 Citations

21,341 Views

25 Pages

Vitamin K Supplementation for the Prevention of Cardiovascular Disease: Where Is the Evidence? A Systematic Review of Controlled Trials

Caitlyn Vlasschaert,
Chloe J. Goss,
Nathan G. Pilkey,
Sandra McKeown and
Rachel M. Holden

Nutrients2020, 12(10), 2909;https://doi.org/10.3390/nu12102909

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23 September 2020

Matrix gla protein (MGP) is an important vitamin K-dependent inhibitor of vascular calcification. High levels of uncarboxylated, dephosphorylated MGP have been associated with vascular calcification and are responsive to vitamin K treatment. In this...

Article

2 Citations

2,652 Views

9 Pages

The Active Isoforms of MGP Are Expressed in Healthy and Varicose Veins without Calcification

Simona R. Gheorghe,
Cees Vermeer,
Gabriel Olteanu,
Ciprian N. Silaghi and
Alexandra M. Crăciun

J. Clin. Med.2021, 10(24), 5896;https://doi.org/10.3390/jcm10245896

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15 December 2021

Matrix Gla protein (MGP), a local inhibitor of tissue mineralization, is associated with vascular calcification. Depending on the carboxylation and phosphorylation status, MGP has active conformations, e.g., carboxylated MGP (cMGP) and phosphorylated...

Article

12 Citations

3,431 Views

13 Pages

Kidney Function-Dependence of Vitamin K-Status Parameters: Results from the TransplantLines Biobank and Cohort Studies

Daan Kremer,
Dion Groothof,
Charlotte A. Keyzer,
Coby Eelderink,
Tim J. Knobbe,
Adrian Post,
Marco van Londen,
Michele F. Eisenga,
TransplantLines Investigators and
Leon J. Schurgers
+ 3 authors

Nutrients2021, 13(9), 3069;https://doi.org/10.3390/nu13093069

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31 August 2021

High circulating dephosphorylated (dp) uncarboxylated (uc) matrix Gla protein (MGP) and uc osteocalcin (OC) concentrations are regarded as markers of vitamin K-deficiency. However, because MGP and OC are small molecules, they may potentially pass the...

Article

12 Citations

6,423 Views

10 Pages

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults

Adriana J. van Ballegooijen,
Joline W. J. Beulens,
Leon J. Schurgers,
Elisa J. de Koning,
Paul Lips,
Natasja M. van Schoor and
Marc G. Vervloet

Nutrients2019, 11(2), 231;https://doi.org/10.3390/nu11020231

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22 January 2019

Vitamin D supplementation has been widely promoted to restore 25-hydroxyvitamin D concentrations; however, experimental evidence suggests a nutrient interaction with vitamin K. We assessed the effects of 1200 IU vitamin D3 per day versus placebo for...

Article

40 Citations

11,037 Views

9 Pages

The Association of Low Vitamin K Status with Mortality in a Cohort of 138 Hospitalized Patients with COVID-19

Allan Linneberg,
Freja Bach Kampmann,
Simone Bastrup Israelsen,
Liv Rabøl Andersen,
Henrik Løvendahl Jørgensen,
Håkon Sandholt,
Niklas Rye Jørgensen,
Sanne Marie Thysen and
Thomas Benfield

Nutrients2021, 13(6), 1985;https://doi.org/10.3390/nu13061985

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9 June 2021

It has recently been hypothesized that vitamin K could play a role in COVID-19. We aimed to test the hypotheses that low vitamin K status is a common characteristic of patients hospitalized with COVID-19 compared to population controls and that low v...

Article

1,329 Views

13 Pages

Low Vitamin K Status and Risk of Chronic Obstructive Pulmonary Disease

Daniel Alexander Ackermann,
Allan Linneberg,
Ema Rastoder,
Anna Kubel Vognsen,
Anne Ahrendt Bjerregaard,
Lennart Friis-Hansen,
Niklas Rye Jørgensen,
Caroline Emma Hedsund,
Niklas Dyrby Johansen and
Daniel Modin
+ 14 authors

Biomedicines2025, 13(4), 807;https://doi.org/10.3390/biomedicines13040807

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27 March 2025

Background: Vitamin K is a cofactor necessary for the biological activity of proteins like Matrix Gla Protein (MGP), which reduce calcification and help preserve lung function. This study aims to determine, first, whether low vitamin K status is asso...

Article

10 Citations

3,856 Views

13 Pages

Development of the BioHybrid Assay: Combining Primary Human Vascular Smooth Muscle Cells and Blood to Measure Vascular Calcification Propensity

Armand M. G. Jaminon,
Asim C. Akbulut,
Niko Rapp,
Rafael Kramann,
Erik A. L. Biessen,
Lieve Temmerman,
Barend Mees,
Vincent Brandenburg,
Robert Dzhanaev and
Willi Jahnen-Dechent
+ 4 authors

Cells2021, 10(8), 2097;https://doi.org/10.3390/cells10082097

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16 August 2021

Background: Vascular calcification is an active process that increases cardiovascular disease (CVD) risk. There is still no consensus on an appropriate biomarker for vascular calcification. We reasoned that the biomarker for vascular calcification is...