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Open AccessArticle

Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults

1
Department of Nephrology, and Amsterdam Cardiovascular Science, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
2
Department of Epidemiology & Biostatistics, and the Amsterdam Public Health Institute, VU University Medical Center, 1081 HV Amsterdam, The Netherlands
3
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, 3508 AB Utrecht, The Netherlands
4
Department of Biochemistry, Maastricht University, 6211 LK Maastricht, The Netherlands
5
Department of Internal Medicine, and Amsterdam Public Health Research Institute, VU University Medical Center, 1007 MB Amsterdam, The Netherlands
*
Author to whom correspondence should be addressed.
Nutrients 2019, 11(2), 231; https://doi.org/10.3390/nu11020231
Received: 5 December 2018 / Revised: 2 January 2019 / Accepted: 16 January 2019 / Published: 22 January 2019
Vitamin D supplementation has been widely promoted to restore 25-hydroxyvitamin D concentrations; however, experimental evidence suggests a nutrient interaction with vitamin K. We assessed the effects of 1200 IU vitamin D3 per day versus placebo for six months on vitamin K status in a randomized, double-blind, placebo-controlled trial with participants aged 60–80 years with depressive symptoms and ≥1 functional limitation for a secondary analysis. Stored baseline and six-month follow-up blood samples were available for 131 participants (n = 65 placebo vs. n = 66 vitamin D supplementation). We measured dephosphorylated uncarboxylated matrix gla protein (MGP) (dp-ucMGP) concentrations—a marker of vitamin K deficiency. Mean age was 68 years, and 89 participants (68%) were women. Vitamin K antagonists were used by 16 participants and multivitamin supplements by 50 participants. No differences in change between intervention and placebo were found (−38.5 ± 389 vs. 4.5 ± 127 (pmol/L), p = 0.562). When excluding vitamin K antagonist users and multivitamin users, dp-ucMGP at follow-up was significantly higher in the vitamin D group (n = 40) compared to placebo (n = 30), with a difference of 92.8 (5.7, 180) pmol/L, adjusting for baseline dp-ucMGP and sex. In conclusion, vitamin D supplementation for six months did not affect vitamin K status; however, among participants without vitamin K antagonist or multivitamin use, vitamin D supplementation influenced dp-ucMGP concentrations. View Full-Text
Keywords: vitamin D supplementation; vitamin K status; randomized controlled trial vitamin D supplementation; vitamin K status; randomized controlled trial
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van Ballegooijen, A.J.; Beulens, J.W.J.; Schurgers, L.J.; de Koning, E.J.; Lips, P.; van Schoor, N.M.; Vervloet, M.G. Effect of 6-Month Vitamin D Supplementation on Plasma Matrix Gla Protein in Older Adults. Nutrients 2019, 11, 231.

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