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12 Results Found

  • Article
  • Open Access
17 Citations
5,165 Views
16 Pages

Self-Controlled Cleaving Method for Silicon DRIE Process Cross-Section Characterization

  • Dmitry A. Baklykov,
  • Mihail Andronic,
  • Olga S. Sorokina,
  • Sergey S. Avdeev,
  • Kirill A. Buzaverov,
  • Ilya A. Ryzhikov and
  • Ilya A. Rodionov

Advanced microsystems widely used in integrated optoelectronic devices, energy harvesting components, and microfluidic lab-on-chips require high-aspect silicon microstructures with a precisely controlled profile. Such microstructures can be fabricate...

  • Article
  • Open Access
4 Citations
3,843 Views
15 Pages

Multi-Foci Laser Separation of Sapphire Wafers with Partial Thickness Scanning

  • Celescia Siew Mun Lye,
  • Zhongke Wang and
  • Yee Cheong Lam

24 March 2022

With multi-foci laser cutting technology for sapphire wafer separation, the entire cross-section is generally scanned with single or multiple passes. This investigation proposes a new separation technique through partial thickness scanning. The energ...

  • Article
  • Open Access
21 Citations
4,536 Views
17 Pages

4 February 2023

Muscle atrophy is characterized by a decline in muscle mass and function. Excessive glucocorticoids in the body due to aging or drug treatment can promote muscle wasting. In this study, we investigated the preventive effect of Nelumbo nucifera leaf (...

  • Article
  • Open Access
31 Citations
4,165 Views
12 Pages

Dexamethasone (Dexa), frequently used as an anti-inflammatory agent, paradoxically leads to muscle inflammation and muscle atrophy. Receptor for advanced glycation end products (RAGE) and Toll-like receptor 4 (TLR4) lead to nucleotide-binding oligome...

  • Communication
  • Open Access
63 Citations
6,550 Views
17 Pages

Autophagy, Apoptosis, the Unfolded Protein Response, and Lung Function in Idiopathic Pulmonary Fibrosis

  • Pawan Sharma,
  • Javad Alizadeh,
  • Maya Juarez,
  • Afshin Samali,
  • Andrew J. Halayko,
  • Nicholas J. Kenyon,
  • Saeid Ghavami and
  • Amir A. Zeki

30 June 2021

Autophagy, apoptosis, and the unfolded protein response (UPR) are fundamental biological processes essential for manifold cellular functions in health and disease. Idiopathic pulmonary fibrosis (IPF) is a progressive and lethal pulmonary disorder ass...

  • Article
  • Open Access
1 Citations
1,629 Views
14 Pages

The Impact of Carbon on Electronic Structure of N-Doped ZnO Films: Scanning Photoelectron Microscopy Study and DFT Calculations

  • Elzbieta Guziewicz,
  • Sushma Mishra,
  • Matteo Amati,
  • Luca Gregoratti and
  • Oksana Volnianska

27 December 2024

A Scanning Photoelectron Microscopy (SPEM) experiment has been applied to ZnO:N films deposited by Atomic Layer Deposition (ALD) under O-rich conditions and post-growth annealed in oxygen at 800 °C. State-of-the-Art spatial resolution (130 nm) al...

  • Article
  • Open Access
11 Citations
4,982 Views
22 Pages

The Interplay among Glucocorticoid Therapy, Platelet-Activating Factor and Endocannabinoid Release Influences the Inflammatory Response to COVID-19

  • Jonatan C. S. de Carvalho,
  • Pedro V. da Silva-Neto,
  • Diana M. Toro,
  • Carlos A. Fuzo,
  • Viviani Nardini,
  • Vinícius E. Pimentel,
  • Malena M. Pérez,
  • Thais F. C. Fraga-Silva,
  • Camilla N. S. Oliveira and
  • on behalf of the ImmunoCovid Study Group
  • + 17 authors

19 February 2023

COVID-19 is associated with a dysregulated immune response. Currently, several medicines are licensed for the treatment of this disease. Due to their significant role in inhibiting pro-inflammatory cytokines and lipid mediators, glucocorticoids (GCs)...

  • Article
  • Open Access
13 Citations
3,886 Views
15 Pages

Valproic Acid Reduces Vasospasm through Modulation of Akt Phosphorylation and Attenuates Neuronal Apoptosis in Subarachnoid Hemorrhage Rats

  • Chieh-Hsin Wu,
  • Yi-Cheng Tsai,
  • Tai-Hsin Tsai,
  • Keng-Liang Kuo,
  • Yu-Feng Su,
  • Chih-Hui Chang and
  • Chih-Lung Lin

Aneurysmal subarachnoid hemorrhage (SAH) is a devastating emergent event associated with high mortality and morbidity. Survivors usually experience functional neurological sequelae caused by vasospasm-related delayed ischemia. In this study, male Spr...

  • Article
  • Open Access
9 Citations
3,547 Views
10 Pages

ZMPSTE24 Is Associated with Elevated Inflammation and Progerin mRNA

  • Moritz Messner,
  • Santhosh Kumar Ghadge,
  • Thomas Maurer,
  • Michael Graber,
  • Simon Staggl,
  • Sarah Christine Maier,
  • Gerhard Pölzl and
  • Marc-Michael Zaruba

28 August 2020

Lamins are important filaments forming the inner nuclear membrane. Lamin A is processed by zinc metalloproteinase (ZMPSTE24). Failure to cleave a truncated form of prelamin A—also called progerin—causes Hutchinson–Gilford progeria s...

  • Article
  • Open Access
1,285 Views
15 Pages

Chestnut (Castanea crenata) Inner-Shell Extract Attenuates Barium-Chloride-Induced Injury and Denervation-Induced Atrophy in Skeletal Muscle of Mice

  • Jin-Hwa Kim,
  • Eun-Hye Chung,
  • Jeong-Won Kim,
  • Ji-Soo Jeong,
  • Chang-Yeop Kim,
  • Su-Ha Lee,
  • Je-Won Ko,
  • Je-Oh Lim and
  • Tae-Won Kim

26 June 2025

Background/Objectives: Chestnut inner shells, traditionally used in Korean and Chinese herbal medicine, contain antioxidant and anti-inflammatory compounds that contribute to complementary medicine. This study aimed to explore the therapeutic effects...

  • Article
  • Open Access
76 Citations
8,359 Views
7 Pages

High-Temperature Sensor Based on Fabry-Perot Interferometer in Microfiber Tip

  • Zhenshi Chen,
  • Songsong Xiong,
  • Shecheng Gao,
  • Hui Zhang,
  • Lei Wan,
  • Xincheng Huang,
  • Bingsen Huang,
  • Yuanhua Feng,
  • Weiping Liu and
  • Zhaohui Li

12 January 2018

A miniaturized tip Fabry-Perot interferometer (tip-FPI) is proposed for high-temperature sensing. It is simply fabricated for the first time by splicing a short length of microfiber (MF) to the cleaved end of a standard single mode fiber (SMF) with p...

  • Article
  • Open Access
7 Citations
3,630 Views
19 Pages

MCC950 Ameliorates Diabetic Muscle Atrophy in Mice by Inhibition of Pyroptosis and Its Synergistic Effect with Aerobic Exercise

  • Xiaoyu Yan,
  • Pengyu Fu,
  • Yimin Zhang,
  • Dongmei Ling,
  • Lewis Reynolds,
  • Weicheng Hua,
  • Zhiyuan Wang,
  • Fangyuan Ma,
  • Boxuan Li and
  • Enming Zhang
  • + 3 authors

4 February 2024

Diabetic muscle atrophy is an inflammation-related complication of type-2 diabetes mellitus (T2DM). Even though regular exercise prevents further deterioration of atrophic status, there is no effective mediator available for treatment and the underly...