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Article

12 Citations

6,684 Views

13 Pages

Novel Substituted Heteroaromatic Piperazine and Piperidine Derivatives as Inhibitors of Human Enterovirus 71 and Coxsackievirus A16

Xian Zhang,
Hongliang Wang,
Yuhuan Li,
Ruiyuan Cao and ,
Wu Zhong,
Zhibing Zheng,
Gang Wang,
Junhai Xiao and
Song Li
+ 4 authors+ 0 author

Molecules2013, 18(5), 5059-5071;https://doi.org/10.3390/molecules18055059

29 April 2013

A series of substituted heteroaromatic piperazine and piperidine derivatives were found through virtual screening based on the structure of human enterovirus 71 capsid protein VP1. The preliminary biological evaluation revealed that compounds 8e and...

(This article belongs to the Section Medicinal Chemistry)

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Article

16 Citations

6,185 Views

22 Pages

Discovery of Novel Andrographolide Derivatives as Antiviral Inhibitors against Human Enterovirus A71

Jie Kai Tan,
Ran Chen,
Regina Ching Hua Lee,
Feng Li and ,
Kun Dai,
Guo-Chun Zhou and
Justin Jang Hann Chu
+ 2 authors+ 0 author

Pharmaceuticals2022, 15(2), 115;https://doi.org/10.3390/ph15020115

18 January 2022

Hand-foot-and-mouth disease (HFMD) caused by human enterovirus A71 (EV-A71) infection has been associated with severe neurological complications. With the lack of an internationally approved antiviral, coupled with a surge in outbreaks globally, EV-A...

(This article belongs to the Special Issue Antiviral Compounds in Medicinal Plants)

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Article

1,221 Views

21 Pages

HSBDF-Derived Bioactive Components Broadly Inhibit Enteroviruses by Targeting 3C Protease and Attenuating Inflammatory Responses

Ruolan Hu,
Lin Guan,
Siyue Li,
Chunlin Liu and ,
Gang Huang,
Fuxing Lou,
Hongzheng Jiang,
Shuqi Wang,
Zehan Pang and
Bixia Hong
+ 10 authors+ 5 authors

Biology2025, 14(11), 1615;https://doi.org/10.3390/biology14111615

18 November 2025

Human enteroviruses are important pathogens of hand-foot-and-mouth disease, poliomyelitis, and encephalitis, etc., posing substantial global health burdens with no specific approved therapeutics. While traditional Chinese medicine (TCM) has demonstra...

(This article belongs to the Section Infection Biology)

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12 Citations

3,998 Views

12 Pages

Computational Screening of Newly Designed Compounds against Coxsackievirus A16 and Enterovirus A71

Amita Sripattaraphan,
Kamonpan Sanachai,
Warinthorn Chavasiri,
Siwaporn Boonyasuppayakorn and ,
Phornphimon Maitarad and
Thanyada Rungrotmongkol
+ 1 author+ 0 author

Molecules2022, 27(6), 1908;https://doi.org/10.3390/molecules27061908

15 March 2022

Outbreaks of hand, foot, and mouth disease (HFMD) that occur worldwide are mainly caused by the Coxsackievirus-A16 (CV-A16) and Enterovirus-A71 (EV-A71). Unfortunately, neither an anti-HFMD drug nor a vaccine is currently available. Rupintrivir in ph...

(This article belongs to the Special Issue Integrative Computational Strategies for Drug Screening)

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