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12 Results Found

  • Article
  • Open Access
3 Citations
3,623 Views
14 Pages

TRNT-1 Deficiency Is Associated with Loss of tRNA Integrity and Imbalance of Distinct Proteins

  • Thet Fatica,
  • Turaya Naas,
  • Urszula Liwak,
  • Hannah Slaa,
  • Maryam Souaid,
  • Brianna Frangione,
  • Ribal Kattini,
  • Antoine Gaudreau-Lapierre,
  • Laura Trinkle-Mulcahy and
  • Martin Holcik
  • + 1 author

5 May 2023

Mitochondrial diseases are a group of heterogeneous disorders caused by dysfunctional mitochondria. Interestingly, a large proportion of mitochondrial diseases are caused by defects in genes associated with tRNA metabolism. We recently discovered tha...

  • Review
  • Open Access
26 Citations
5,048 Views
14 Pages

Diseases Associated with Defects in tRNA CCA Addition

  • Angelo Slade,
  • Ribal Kattini,
  • Chloe Campbell and
  • Martin Holcik

tRNA nucleotidyl transferase 1 (TRNT1) is an essential enzyme catalyzing the addition of terminal cytosine-cytosine-adenosine (CCA) trinucleotides to all mature tRNAs, which is necessary for aminoacylation. It was recently discovered that partial los...

  • Review
  • Open Access
21 Citations
5,687 Views
20 Pages

Fundamentals of Rhenium-188 Radiopharmaceutical Chemistry

  • Janke Kleynhans,
  • Adriano Duatti and
  • Cristina Bolzati

3 February 2023

The β− emitter, rhenium-188 (188Re), has long been recognized as an attractive candidate for targeted cancer radionuclide therapy (TRNT). This transition metal shares chemical similarities with its congener element technetium, whose nuclea...

  • Article
  • Open Access
7 Citations
3,546 Views
15 Pages

Exploring the Potential of High-Molar-Activity Samarium-153 for Targeted Radionuclide Therapy with [153Sm]Sm-DOTA-TATE

  • Koen Vermeulen,
  • Michiel Van de Voorde,
  • Charlotte Segers,
  • Amelie Coolkens,
  • Sunay Rodriguez Pérez,
  • Noami Daems,
  • Charlotte Duchemin,
  • Melissa Crabbé,
  • Tomas Opsomer and
  • Maarten Ooms
  • + 7 authors

Samarium-153 is a promising theranostic radionuclide, but low molar activities (Am) resulting from its current production route render it unsuitable for targeted radionuclide therapy (TRNT). Recent efforts combining neutron activation of 152Sm in the...

  • Review
  • Open Access
89 Citations
9,730 Views
25 Pages

Bismuth-213 for Targeted Radionuclide Therapy: From Atom to Bedside

  • Stephen Ahenkorah,
  • Irwin Cassells,
  • Christophe M. Deroose,
  • Thomas Cardinaels,
  • Andrew R. Burgoyne,
  • Guy Bormans,
  • Maarten Ooms and
  • Frederik Cleeren

In contrast to external high energy photon or proton therapy, targeted radionuclide therapy (TRNT) is a systemic cancer treatment allowing targeted irradiation of a primary tumor and all its metastases, resulting in less collateral damage to normal t...

  • Article
  • Open Access
7 Citations
3,519 Views
18 Pages

21 June 2022

Long non-coding regions (NCRs) and gene rearrangements are commonly seen in mitochondrial genomes of Mantodea and are primarily focused on three regions: CR-I-Q-M-ND2, COX2-K-D-ATP8, and ND3-A-R-N-S-E-F-ND5. In this study, eight complete and one near...

  • Article
  • Open Access
1 Citations
1,429 Views
18 Pages

Applications for Circulating Cell-Free DNA in Oral Squamous Cell Carcinoma: A Non-Invasive Approach for Detecting Structural Variants, Fusions, and Oncoviruses

  • Mahua Bhattacharya,
  • Dan Yaniv,
  • Dylan P. D’Souza,
  • Eyal Yosefof,
  • Sharon Tzelnick,
  • Rajesh Detroja,
  • Tal Wax,
  • Adva Levy-Barda,
  • Gideon Baum and
  • Milana Frenkel Morgenstern
  • + 2 authors

6 June 2025

Background: Circulating cell-free DNA (cfDNA) has been widely used as a prognostic marker for different cancers. Objective: In this study, we used 30 cfDNA samples from oral squamous cell carcinoma (OSCC), 199 public OSCC samples, and 192 normal samp...

  • Article
  • Open Access
43 Citations
6,588 Views
20 Pages

15 June 2020

Within the family Solanaceae, Withania is a small genus belonging to the Solanoideae subfamily. Here, we report the de novo assembled chloroplast genome sequences of W. coagulans, W. adpressa, and W. riebeckii. The length of these genomes ranged from...

  • Article
  • Open Access
4 Citations
2,480 Views
16 Pages

Plastid Phylogenomics Provide Evidence to Accept Two New Members of Ligusticopsis (Apiaceae, Angiosperms)

  • Changkun Liu,
  • Jiaojiao Deng,
  • Renxiu Zhou,
  • Boni Song,
  • Songdong Zhou and
  • Xingjin He

26 December 2022

Peucedanum nanum and P. violaceum are recognized as members of the genus Peucedanum because of their dorsally compressed mericarps with slightly prominent dorsal ribs and narrowly winged lateral ribs. However, these species are not similar to other P...

  • Article
  • Open Access
73 Citations
6,810 Views
14 Pages

3 January 2019

Species belonging to Rosa section Synstylae (Rosaceae) are mainly distributed in East Asia, and represent recently diverged lineages within the genus. Over decades, inferring phylogenetic relationships within section Synstylae have been exceptional c...

  • Article
  • Open Access
1 Citations
1,095 Views
19 Pages

Comprehensive Whole-Genome Survey and Analysis of the Naozhou Stock of Large Yellow Croakers (Larimichthys crocea)

  • Hao-Jie Wang,
  • Shu-Pei Huang,
  • Eric Amenyogbe,
  • Yue Liu,
  • Jing-Hui Jin,
  • Yi Lu,
  • Charles Narteh Boateng,
  • Zhong-Liang Wang and
  • Jian-Sheng Huang

25 August 2025

The Naozhou stock of large yellow croakers (Larimichthys crocea) exhibits unique phenotypic traits and high genetic diversity, making it a valuable resource for selective breeding and genetic conservation in aquaculture. Despite its importance, simpl...

  • Article
  • Open Access
6 Citations
3,962 Views
18 Pages

30 July 2021

The complete mitogenomes of nine fulgorid species were sequenced and annotated to explore their mitogenome diversity and the phylogenetics of Fulgoridae. All species are from China and belong to five genera: Dichoptera Spinola, 1839 (Dichoptera sp.);...