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6 Results Found

  • Article
  • Open Access
15 Citations
6,391 Views
20 Pages

Differentially Expressed Mitochondrial Proteins in Human MCF7 Breast Cancer Cells Resistant to Paclitaxel

  • Petr Daniel,
  • Petr Halada,
  • Michael Jelínek,
  • Kamila Balušíková and
  • Jan Kovář

Identification of novel proteins with changed expression in resistant cancer cells could be helpful in elucidation mechanisms involved in the development of acquired resistance to paclitaxel. In this study, we carried out a 2D-PAGE using the mitochon...

(This article belongs to the Section Molecular Biology)
  • Article
  • Open Access
2 Citations
5,114 Views
16 Pages

30 October 2022

Prostate adenocarcinoma (PRAD) is the most common histological subtype of prostate cancer. Post-treatment biochemical recurrence is a challenging issue. ATAD1 (ATPase Family AAA Domain Containing 1) plays a vital role in mitochondrial proteostasis an...

(This article belongs to the Special Issue Application Research of Bioinformatics in Human Diseases)
  • Review
  • Open Access
15 Citations
6,042 Views
12 Pages

6 May 2020

The Rvb1-Rvb2-Tah1-Pih1 (R2TP) complex is a co-chaperone complex that works together with HSP90 in the activation and assembly of several macromolecular complexes, including RNA polymerase II (Pol II) and complexes of the phosphatidylinositol-3-kinas...

(This article belongs to the Special Issue Molecular Chaperones: Cancer and Cell Death)
  • Review
  • Open Access
69 Citations
11,211 Views
28 Pages

Valosin-Containing Protein (VCP)/p97: A Prognostic Biomarker and Therapeutic Target in Cancer

  • Susan Costantini,
  • Francesca Capone,
  • Andrea Polo,
  • Palmina Bagnara and
  • Alfredo Budillon

21 September 2021

Valosin-containing protein (VCP)/p97, a member of the AAA+ ATPase family, is a molecular chaperone recruited to the endoplasmic reticulum (ER) membrane by binding to membrane adapters (nuclear protein localization protein 4 (NPL4), p47 and ubiquitin...

(This article belongs to the Section Molecular Oncology)
  • Article
  • Open Access
16 Citations
4,169 Views
21 Pages

Mammalian Homologue NME3 of DYNAMO1 Regulates Peroxisome Division

  • Masanori Honsho,
  • Yuichi Abe,
  • Yuuta Imoto,
  • Zee-Fen Chang,
  • Hanna Mandel,
  • Tzipora C. Falik-Zaccai and
  • Yukio Fujiki

28 October 2020

Peroxisomes proliferate by sequential processes comprising elongation, constriction, and scission of peroxisomal membrane. It is known that the constriction step is mediated by a GTPase named dynamin-like protein 1 (DLP1) upon efficient loading of GT...

(This article belongs to the Special Issue Selected Papers from the 11th International Conference on the NME/NDPK/NM23/AWD Gene Family (NME 2019))
  • Article
  • Open Access
1 Citations
1,202 Views
20 Pages

Atad1 Is a Potential Candidate Gene for Prepulse Inhibition

  • Akhilesh K. Bajpai,
  • Timothy G. Freels,
  • Lu Lu and
  • Melloni N. Cook

26 September 2025

Background/Objectives: Prepulse inhibition (PPI) is a robust, reproducible phenotype associated with schizophrenia and other psychiatric disorders. This study was carried out to identify gene(s) influencing PPI. Methods: We performed Quantitative Tra...

(This article belongs to the Special Issue Genetics of Neuropsychiatric Disorders)