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  • Article
  • Open Access
17 Citations
5,278 Views
11 Pages

The Anxiolytic-like Properties of a Tryptic Hydrolysate of Bovine αs1 Casein Containing α-Casozepine Rely on GABAA Receptor Benzodiazepine Binding Sites but Not the Vagus Nerve

  • Simon Benoit,
  • Catherine Chaumontet,
  • Nicolas Violle,
  • Audrey Boulier and ,
  • Zeeshan Hafeez,
  • Céline Cakir-Kiefer,
  • Daniel Tomé,
  • Jessica Schwarz and
  • Laurent Miclo
  • + 4 authors+ 0 author

26 May 2022

(1) Background: A tryptic hydrolysate of bovine αs1-casein (CH) exerts anxiolytic-like properties in many species, including humans. This is mainly related to the presence of α-casozepine (α-CZP), which yields these properties in ro...

(This article belongs to the Section Nutrition and Public Health)
  • Article
  • Open Access
27 Citations
7,036 Views
12 Pages

Anxiolytic Activity and Brain Modulation Pattern of the α-Casozepine-Derived Pentapeptide YLGYL in Mice

  • Simon Benoit,
  • Catherine Chaumontet,
  • Jessica Schwarz,
  • Céline Cakir-Kiefer and ,
  • Audrey Boulier,
  • Daniel Tomé and
  • Laurent Miclo
  • + 2 authors+ 0 author

21 May 2020

α-Casozepine (α-CZP) is an anxiolytic-like bioactive decapeptide derived from bovine αs1-casein. The N-terminal peptide YLGYL was previously identified after proteolysis of the original peptide in an in vitro digestion model. Its pu...

(This article belongs to the Section Nutrition and Metabolism)
  • Case Report
  • Open Access
9 Citations
6,257 Views
8 Pages

Combining α-s1 Casozepine and Fluoxetine Treatment with a Behavioral Therapy Improves Symptoms in an Aggressive Dog: An Italian Case Report

  • Luigi Sacchettino,
  • Viviana Orsola Giuliano,
  • Luigi Avallone,
  • Francesco Napolitano and
  • Danila d’Angelo

Behavioral dysfunctions in dogs represent a critical issue of the human–animal relationship. In particular, aggression can make interspecific coexistence quite complicated within family units, thus exposing all members to greater health risks....

(This article belongs to the Section Veterinary Education, Veterinary Communication and Animal Behavior)
  • Article
  • Open Access
7 Citations
6,652 Views
12 Pages

Cats at the Vet: The Effect of Alpha-s1 Casozepin

  • Adjet Makawey,
  • Christine Iben and
  • Rupert Palme

5 November 2020

The aim of this study was to evaluate the impact of α-s1 casozepin on cat stress responses at a veterinary practice. Cats feel confident in their familiar surroundings and daily routine. A visit, and transport, to the veterinarian is a stressfu...

(This article belongs to the Section Animal Welfare)