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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Oncogenic Infections and Cancer: Clinical Insights and Emerging Therapeutics

edited by G. Hossein Ashrafi and Mustafa Ozdogan

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2451 | Submission Open

Keywords: oncogenesis; viral oncology; bacterial oncogenesis; human papillomavirus (HPV); Epstein– Barr virus (EBV); Kaposi’ s sarcoma-associated herpesvirus (KSHV); hepatitis B virus (HBV); hepatitis C virus (HCV); human T-lymphotropic virus (HTLV-1); Helicobacter pylori; infection-driven cancers; molecular mechanisms; tumor microenvironment; immunotherapy; viral persistence; antiviral therapies; CRISPR-based treatments; cancer prevention; vaccine development; immune checkpoint inhibitors; diagnostic biomarkers; personalized medicine; translational oncology; therapeutic resistance; emerging therapeutics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Coronavirus Pathogenesis and Virus-Host Interaction

edited by

Hin Chu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2378 | Submission Open

Keywords: COVID-19; SARS-CoV-2; SARS-CoV-1; MERS-CoV; pathogenesis; virus– host interaction; virus entry; host factors; animal models; SARS-CoV-2 variants

(This special issue belongs to the Section General Virology)

Zika Virus and Congenital Zika Syndrome, 2nd Edition

edited by Marcos Vinicius da Silva Pone and Sheila Moura Pone

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2163 | Submission Open

Keywords: viral infections; Zika virus; congenital Zika syndrome

(This special issue belongs to the Section Human Virology and Viral Diseases)

Early Diagnosis and Surveillance of Transboundary and Emerging Viral Diseases of Animals, 2nd Edition

edited by

Aruna Ambagala

and

Kalhari Goonewardene

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2030 | Submission Open

Keywords: diagnostics; surveillance; transboundary; emerging; animal diseases; virus; detection; validation; novel; sample types; alternative

(This special issue belongs to the Section Animal Viruses)

Virological and Immunological Factors Underlying HBV Functional Cure and HBV Reactivation

edited by

Valentina Svicher

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1938 | Submission Open

Keywords: HBV persistence; HBV functional cure; cccDNA; immunology of HBV; HBV reactivation; immune-escape mutations

(This special issue belongs to the Section Human Virology and Viral Diseases)

Harnessing AI and Machine Learning for Antiviral Development

edited by

X. Frank Zhang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1896 | Submission Open

Keywords: artificial intelligence; machine learning; antiviral therapies; personalized medicine; drug discovery; drug repurposing; drug resistance

(This special issue belongs to the Section General Virology)

Picornavirus Evolution, Host Adaptation and Antiviral Strategies

edited by

Leyi Wang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1854 | Submission Open

Keywords: virus evolution; new picornavirus; variant picornavirus; host adaptation; vaccine immunization; antiviral drugs

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virology and Immunology of Gene Therapy 2025

edited by Weidong Xiao and

Jianming Qiu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1602 | Submission Open

Keywords: gene therapy; viral vector; vaccine; immune responses; viruses; AAV; lentiviral vectors; neutralizing antibody

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Cyanophage and Algal Virus

edited by

Rodrigo Araújo Lima Rodrigues

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1502 | Submission Open

Keywords: cyanophages; algal viruses; Algavirales; Phycodnaviridae; Marnaviridae; aquatic virus; algae bloom; viral diversity; viral ecology

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Current: Measles Outbreak, a Global Situation

edited by

S. Louise Cosby

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1427 | Submission Open

Keywords: measles; vaccination; surveillance; complications; outbreaks

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Immunology in Transplant Patients

edited by

Alessandro Perrella

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1385 | Submission Open

Keywords: viral infections; transplant patients; immunocompromised; immune response; host– pathogen interactions; immunotherapies; diagnostic approaches; preventive strategies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Arboviruses and Climate, 2nd Edition

edited by José Lourenço and

Marta Giovanetti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1188 | Submission Open

Keywords: arbovirus; climate; climate change; arthropods; vectors; epidemiology; evolution; ecology; public health

(This special issue belongs to the Section Invertebrate Viruses)

Virus Biosensing

edited by Guobin Mao

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1067 | Submission Open

Keywords: virus detection; molecular diagnosis; immunoassay; nucleic acid amplification; CRISPR-based detection; nucleic acid assembly; biosensor; point-of-care testing

(This special issue belongs to the Section General Virology)

The Structure and Function of Flavivirus Genes and Proteins

edited by

Tadahisa Teramoto

and Kay Choi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1065 | Submission Open

Keywords: flavivirus; structural protein; non-structural protein; 5'UTR; 3'UTR

(This special issue belongs to the Section General Virology)

Phage Display in Cancer Diagnosis and Screening

edited by

Valery A. Petrenko

submission deadline 31 Dec 2025 | 1 articles | Viewed by 932 | Submission Open

Keywords: phage display; cancer; diagnosis; screening; prognosis and monitoring

(This special issue belongs to the Section Bacterial Viruses)

Virus Bioinformatics 2025

edited by

Manja Marz

and

Maria Fabisch

submission deadline 31 Dec 2025 | Viewed by 771 | Submission Open

Keywords: virus bioinformatics; software; viral metagenomics and ecology; virus– host interactions; viral diversity and evolution; virus identification

(This special issue belongs to the Section General Virology)

Antigenic Drift in Respiratory Viruses

edited by

Gabriel Gonzalez

submission deadline 31 Dec 2025 | 1 articles | Viewed by 744 | Submission Open

Keywords: respiratory viruses; virus diversity; viral recombination; reassortment; zoonotic viruses; wastewater pathogen surveillance; viral sequencing; virus evolutionary characterization; animal viruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancing Research of Anelloviruses, Second Edition

edited by

Fabrizio Maggi

and

Pietro Giorgio Spezia

submission deadline 31 Dec 2025 | Viewed by 478 | Submission Open

Keywords: TTV; TTMV; TTMDV; virome; viral species; immune system; orphan virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

RNA Viruses Replication and Innate Immunity

edited by

Griffith Parks

submission deadline 31 Dec 2025 | Viewed by 403 | Submission Open

Keywords: RNA virus replication and transcription; pathogen-associated molecular patterns; interferons; cytokines; signaling pathways

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Spotlight on Bocavirus and Other Parvoviruses, and Overlooked Respiratory Viruses

edited by

Suncanica Ljubin‐Sternak

and

Tatjana Vilibic-Cavlek

submission deadline 31 Dec 2025 | 1 articles | Viewed by 347 | Submission Open

Keywords: bocavirus; Parvovirus B19; canine parvovirus; porcine parvovirus; metapneumovirus; rhinovirus Planned Papers 1. Molecular detection of Porcine cytomegalovirus (PCMV) and Porcine parvovirus (PPV) in domestic pigs and wild boars from Croatia 2. Protoparvovirus carnivoran 1 outbreak in golden jackals in Croatia 3. Epidemiology of parvovirus B19 in Croatian childbearing-aged women: A ten-year seroprevalence study

(This special issue belongs to the Section Animal Viruses)

Tackling Viral Resistance—Advances in Mechanisms, Detection, and Control

edited by

Nuno Taveira

and Claudia Palladino

submission deadline 31 Dec 2025 | Viewed by 326 | Submission Open

Keywords: viral resistance; antiviral therapies; drug resistance mechanisms; epidemiology; diagnostic advancements; clinical management

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Modeling Zoonotic and Vector-Borne Viruses in Evolving Ecological Systems

edited by

Salihu S. Musa

, Sani Isah Abba and Ismail Abdulrashid

submission deadline 31 Dec 2025 | Viewed by 304 | Submission Open

Keywords: zoonotic viruses; vector-borne diseases; climate change and disease dynamics; epidemiological modeling; outbreak forecasting and control; human behavior; virus– host– vector interactions

(This special issue belongs to the Section Animal Viruses)

Experimental Animal and Organoid-Based Lethal Virus Infection Models for Human, Companion Animals and Livestock

edited by

Tomomi Takano

submission deadline 31 Dec 2025 | Viewed by 260 | Submission Open

Keywords: organoid models; experimental animals; lethal virus infections; pathogenesis; vaccine development; therapeutic drugs; in vitro models; in vivo models; human viral infections; companion animal viral infections; livestock viral infections; viral infection models; ferret; hamster; transgenic mouse

(This special issue belongs to the Section General Virology)

Virus Infection Fate Regulation

edited by Andreas Meyerhans and

Gennady Bocharov

submission deadline 31 Dec 2025 | Viewed by 182 | Submission Open

Keywords: virus infection fate; dynamics; immune response; cellular response; regulation

(This special issue belongs to the Section General Virology)

Interferon-Stimulated Genes in Antiviral Immunity

edited by

Chen Liang

submission deadline 31 Dec 2025 | Viewed by 173 | Submission Open

Keywords: interferon-stimulated genes; ISGs; non-coding RNA; viral replication; deep learning tools

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Innovative Drug Discovery for Emerging Viral Diseases, 2nd Edition

edited by Chaoping Chen

submission deadline 31 Dec 2025 | Viewed by 125 | Submission Open

Keywords: antivirals; drug discovery; high-throughput screen; SARS-CoV-2; influenza virus; RSV; zika; ebola virus; chikungunya virus; emerging/re-emerging RNA viral pathogens; host-directed therapies; immunomodulator

(This special issue belongs to the Section General Virology)

Arboviral Diseases in Livestock

edited by

Estelle Venter

and

Antoinette Van Schalkwyk

submission deadline 15 Jan 2026 | 3 articles | Viewed by 3724 | Submission Open

Keywords: arbovirus; epidemiology; diagnostics; vaccines

(This special issue belongs to the Section Animal Viruses)

Progress and Prospects in Oncolytic Virotherapy 2025

edited by

Arianna Calistri

and

Sandra Tuyaerts

submission deadline 15 Jan 2026 | Viewed by 700 | Submission Open

Keywords: oncovirotherapy; chemotherapy; preclinical studies; clinical trials; combinatory strategy; safety profile; therapeutic efficacy; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Phage–Antibiotic Combination Therapy

edited by

Prasanth Manohar

submission deadline 20 Jan 2026 | 2 articles | Viewed by 2323 | Submission Open

Keywords: bacteriophage; antibiotics; phage therapy; phage– antibiotic synergy; combination therapy; in vitro study; sub-lethal dose; emerging alternative; bacteria-killing

(This special issue belongs to the Section Bacterial Viruses)

Novel Strategies to Identify and Eliminate Latent HIV Cells

edited by

Francesco Andrea Procopio

submission deadline 31 Jan 2026 | 1 articles | Viewed by 11132 | Submission Open

Keywords: HIV; HIV-1 infection; antiretroviral therapy (ART); HIV single cell analysis; HIV reservoir; HIV cure

(This special issue belongs to the Section Human Virology and Viral Diseases)

Phage Cocktails: Promising Approaches Against Infections

edited by Jin Woo Jun

submission deadline 31 Jan 2026 | 4 articles | Viewed by 8020 | Submission Open

Keywords: phage cocktail; phage therapy; prophylaxis; infectious diseases; veterinary medicine; agriculture; food industry; zoonoses

(This special issue belongs to the Section Bacterial Viruses)

Tick-Borne Viruses: Transmission and Surveillance, 2nd Edition

edited by

Anna Papa

submission deadline 31 Jan 2026 | 4 articles | Viewed by 7320 | Submission Open

Keywords: tick-borne viruses; transmissibility; vector competence; virulence; interactions; surveillance; discovery; replication; pathogenesis; vaccine development

(This special issue belongs to the Section Invertebrate Viruses)

Plant Virus Spillovers

edited by

Steve Wylie

and

Nuredin Habili

submission deadline 31 Jan 2026 | 3 articles | Viewed by 6308 | Submission Open

Keywords: spillover; emergence; replication; wild-plant virus; transmission; virus-cell interaction; vector

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

TMPRSS2 and Other Host Factors in Influenza Virus and Coronavirus Infections

edited by

Judy Wai Ping Yam

and Sze Keong Tey

submission deadline 31 Jan 2026 | 2 articles | Viewed by 6095 | Submission Open

Keywords: TMPRSS2; host factors; influenza virus; coronavirus; viral infection; treatment of viral diseases

(This special issue belongs to the Section Human Virology and Viral Diseases)

Intra-Patient Viral Evolution and Diversity

edited by Adam A. Capoferri and

Mary Kearney

submission deadline 31 Jan 2026 | 3 articles | Viewed by 5992 | Submission Open

Keywords: intra-patient viral evolution; drug resistance; immune escape; co-evolution; virus persistence; virus evolution

(This special issue belongs to the Section Human Virology and Viral Diseases)

SARS-CoV-2 Neutralizing Antibodies, 3rd Edition

edited by Youchun Wang

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3872 | Submission Open

Keywords: SARS-CoV-2; neutralizing antibodies; neutralization assays; standards; monoclonal antibodies; vaccines; viral variants

(This special issue belongs to the Section Coronaviruses)

Role of Lectins in Viral Infections and Antiviral Intervention

edited by Yuan Guo

submission deadline 31 Jan 2026 | 3 articles | Viewed by 3682 | Submission Open

Keywords: lectin– glycan interaction; membrane fusion; immune evasion; multivalency; glycan conjugates; lectin constructs; antivirals

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Translational Research in Virology

edited by

Kenneth Lundstrom

and

Alaa A. A. Aljabali

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3064 | Submission Open

Keywords: vaccines; antiviral drugs; monoclonal antibodies; viral vectors; self-amplifying RNA; clinical trials; translational medicine; proteomic analysis; antiviral resistance; bioinformatics; structural virology; immune escape mechanisms; viral evolution; diagnostic virology; high-throughput screening; nanotechnology in virology; viral assembly and disassembly; host-pathogen interactions; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Infection in Airway Epithelial Cells

edited by Camille Ehré and Raymond J. Pickles

submission deadline 31 Jan 2026 | 2 articles | Viewed by 3048 | Submission Open

Keywords: respiratory viral infections; airway epithelial cells; virus– host interactions; viral pathogenesis; immune responses; Influenza viruses; respiratory syncytial virus (rsv); coronaviruses; SARS-CoV-2; respiratory tract

(This special issue belongs to the Section Animal Viruses)

Emerging and Re-Emerging Plant Viruses and Vector Complexes: Advances in Characterization, Surveillance, and Mitigation

edited by

Judith K. Brown

and

Jiban Kumar Kundu

submission deadline 31 Jan 2026 | 3 articles | Viewed by 2425 | Submission Open

Keywords: climate change and emerging/re-emerging virus threats; impact of virus evolution on the emerging/re-emerging virus diseases; innovative virus detection and surveillance methods; plant defense and virus resistance mechanisms responding to new outbreaks; plant defenses that respond to virus infection in lieu of extreme climate circumstances; plant virus diseases; plant– virus and/or plant– vector interactions; including tritrophic interactions; plant/crop resistance to viruses and/or arthropod vectors; strategies for management of viruses and vectors; virus– vector interactions; specific scenarios of emerging and reemerging viruses:; insect or mite-transmitted viruses of plants; seed-borne or seed-transmitted viruses of plants; soil-borne or soil-transmitted viruses; viruses infecting nursery crops and trees; water-borne or water-transmitted plant viruses

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

HIV and Drugs of Abuse, 4th Edition

edited by

Maria Cecilia Garibaldi Marcondes

and

Marcus Kaul

submission deadline 31 Jan 2026 | 2 articles | Viewed by 2421 | Submission Open

Keywords: substance use disorders; HIV; HAND; methamphetamine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Rift Valley Fever Virus: New Insights into a One Health Archetype

edited by

Rebekah C. Kading

, Juliette Lewis and Brian H. Bird

submission deadline 31 Jan 2026 | 1 articles | Viewed by 2132 | Submission Open

Keywords: One Health; emerging infectious diseases; mosquito; bunyavirus; arbovirus; medical entomology; medical countermeasures; livestock

(This special issue belongs to the Section Animal Viruses)

Long-Acting Antiretrovirals

edited by Camilla Muccini and Antonella Castagna

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1954 | Submission Open

Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Bluetongue, Epizootic Haemorrhagic Disease, and Other Emerging Orbiviruses, 2nd Edition

edited by

Ludovic Martinelle

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1711 | Submission Open

Keywords: bluetongue; epizootic haemorrhagic disease; orbiviruses; African horse sickness; vector-borne diseases

(This special issue belongs to the Section Animal Viruses)

Emerging Controversies and Advances in Neurovirology

edited by

Karolina Akinosoglou

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1341 | Submission Open

Keywords: neurovirology; viral encephalitis; persistent viral infection; neuroinflammation; viral latency; oncolytic viruses; brain tumors; neurodegeneration; SARS-CoV-2; long COVID; zoonotic viruses; neural organoids; microglia activation; virus– host interactions; viral neuropathogenesis; central nervous system infections; herpesviruses; immune-mediated neurodegeneration; viral reactivation; ethical issues in neurovirology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Cellular Immune Response to Hepatitis Viruses

edited by

Armando Andres Roca Suarez

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1224 | Submission Open

Keywords: viral hepatitis; viral/host interactions; immune response; immune evasion; immunopathogenesis; immunomodulatory therapy; pre-clinical models

(This special issue belongs to the Section Human Virology and Viral Diseases)

Host Defense, Viruses and Cell Death Pathways

edited by

Pascale Krejbich-Trotot

submission deadline 31 Jan 2026 | 1 articles | Viewed by 1194 | Submission Open

Keywords: virus– host; programmed cell death; apoptosis; necroptosis; pyroptosis; viral factors and cell death effector interplay; oncolytic

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viruses in the Reproductive Tract

edited by

Mimi Ghosh

Raina Nakova Fichorova

and Christina Farr

submission deadline 31 Jan 2026 | 1 articles | Viewed by 813 | Submission Open

Keywords: reproductive tract virome; viruses in pregnancy; virus infections and adverse fetal health; virus-associated malignancies of the reproductive tract; immune response to viruses of the reproductive tract; antiviral biomarkers; antiviral vaccines and drugs; hormonal regulation of virus infections

(This special issue belongs to the Section General Virology)

Bornaviruses 2025: News, Gaps and Future Directions

edited by

Christiane E. Herden

submission deadline 31 Jan 2026 | Viewed by 479 | Submission Open

Keywords: bornaviruses; zoonotic; epidemiology; transmission; molecular infection mechanisms; pathogenesis; antiviral

(This special issue belongs to the Section Animal Viruses)

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus: 2nd Edition

edited by Tongqing An and Xingyang Cui

submission deadline 31 Jan 2026 | Viewed by 234 | Submission Open

Keywords: PRRSV; genetic evolution; replication regulation; immunological or pathogenic mechanism; vaccine development; prevention and control

(This special issue belongs to the Section Animal Viruses)

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