TMPRSS2 and Other Host Factors in Influenza Virus and Coronavirus Infections

Dear Colleagues,

Since the early 21st century, epidemics and pandemics caused by highly contagious influenza viruses and coronaviruses have imposed a significant burden on global healthcare systems. In addition to the challenges posed by individual pathogens, co-infections involving SARS-CoV-2—the causative agent of the COVID-19 pandemic—together with influenza viruses and other respiratory pathogens have been reported, presenting an even greater threat to public health. Increasing evidence highlights the critical role of host factors, including various host proteins, immune responses, and genetic determinants, in influencing susceptibility to infections and disease severity. Among these, TMPRSS2 has emerged as a key host protein involved in the entry and activation of both influenza viruses and coronaviruses, notably facilitating SARS-CoV-2 cellular entry and priming viral glycoproteins of other respiratory viruses. While its physiological functions remain incompletely understood, TMPRSS2 represents a promising target for antiviral intervention.

This Special Issue aims to showcase the latest research on the role of TMPRSS2 and other host factors in influenza virus and coronavirus infections, offering new insights into mechanistic pathways, transmission dynamics, immune modulation, and epidemiology. We welcome the submission of original research articles, brief research reports, reviews, and communications addressing these important topics.

Prof. Dr. Judy Wai Ping Yam
Dr. Sze Keong Tey
Guest Editors

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