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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Host Defense, Viruses and Cell Death Pathways

edited by

Pascale Krejbich-Trotot

submission deadline 31 Jan 2026 | 1 articles | Viewed by 728 | Submission Open

Keywords: virus– host; programmed cell death; apoptosis; necroptosis; pyroptosis; viral factors and cell death effector interplay; oncolytic

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

HIV and Drugs of Abuse, 4th Edition

edited by

Maria Cecilia Garibaldi Marcondes

and

Marcus Kaul

submission deadline 31 Jan 2026 | 1 articles | Viewed by 410 | Submission Open

Keywords: substance use disorders; HIV; HAND; methamphetamine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Bornaviruses 2025: News, Gaps and Future Directions

edited by

Christiane E. Herden

submission deadline 31 Jan 2026 | Viewed by 296 | Submission Open

Keywords: bornaviruses; zoonotic; epidemiology; transmission; molecular infection mechanisms; pathogenesis; antiviral

(This special issue belongs to the Section Animal Viruses)

Long-Acting Antiretrovirals

edited by Camilla Muccini and Antonella Castagna

submission deadline 31 Jan 2026 | Viewed by 286 | Submission Open

Keywords: HIV infection; HIV prevention; long-acting; antiretroviral therapy; clinical studies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Dynamics in Aquatic Environments: Pathogens, Transmission and Impacts

edited by

Jesús L. Romalde

submission deadline 31 Jan 2026 | Viewed by 90 | Submission Open

Keywords: waterborne viruses; emerging pathogens; human and animal health; viral dynamics; viral ecology; bacteriophages; transmission

(This special issue belongs to the Section General Virology)

Emerging Controversies and Advances in Neurovirology

edited by

Karolina Akinosoglou

submission deadline 31 Jan 2026 | 1 articles | Viewed by 87 | Submission Open

Keywords: neurovirology; viral encephalitis; persistent viral infection; neuroinflammation; viral latency; oncolytic viruses; brain tumors; neurodegeneration; SARS-CoV-2; long COVID; zoonotic viruses; neural organoids; microglia activation; virus– host interactions; viral neuropathogenesis; central nervous system infections; herpesviruses; immune-mediated neurodegeneration; viral reactivation; ethical issues in neurovirology

(This special issue belongs to the Section Human Virology and Viral Diseases)

Emerging and Re-Emerging Plant Viruses and Vector Complexes: Advances in Characterization, Surveillance, and Mitigation

edited by

Judith K. Brown

and

Jiban Kumar Kundu

submission deadline 31 Jan 2026 | Viewed by 85 | Submission Open

Keywords: climate change and emerging/re-emerging virus threats; impact of virus evolution on the emerging/re-emerging virus diseases; innovative virus detection and surveillance methods; plant defense and virus resistance mechanisms responding to new outbreaks; plant defenses that respond to virus infection in lieu of extreme climate circumstances; plant virus diseases; plant– virus and/or plant– vector interactions; including tritrophic interactions; plant/crop resistance to viruses and/or arthropod vectors; strategies for management of viruses and vectors; virus– vector interactions; specific scenarios of emerging and reemerging viruses:; insect or mite-transmitted viruses of plants; seed-borne or seed-transmitted viruses of plants; soil-borne or soil-transmitted viruses; viruses infecting nursery crops and trees; water-borne or water-transmitted plant viruses

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Bluetongue, Epizootic Haemorrhagic Disease, and Other Emerging Orbiviruses, 2nd Edition

edited by

Ludovic Martinelle

submission deadline 31 Jan 2026 | Viewed by 58 | Submission Open

Keywords: bluetongue; epizootic haemorrhagic disease; orbiviruses; African horse sickness; vector-borne diseases

(This special issue belongs to the Section Animal Viruses)

Research Progress on Porcine Reproductive and Respiratory Syndrome Virus: 2nd Edition

edited by Tongqing An and Xingyang Cui

submission deadline 31 Jan 2026 | Viewed by 45 | Submission Open

Keywords: PRRSV; genetic evolution; replication regulation; immunological or pathogenic mechanism; vaccine development; prevention and control

(This special issue belongs to the Section Animal Viruses)

Congenital Cytomegalovirus Infection, 3rd Edition

edited by

Giovanni Nigro

submission deadline 31 Jan 2026 | Viewed by 42 | Submission Open

Keywords: primary cytomegalovirus infection; pregnancy; CMV screening; hyperimmune globulin; valaciclovir

(This special issue belongs to the Section Human Virology and Viral Diseases)

Antiviral Drugs and Biologics Targeting HIV: Drug Resistance to Newer Treatment and Pre-Exposure Prophylaxis (PrEP) Options 2.0

edited by

Bluma G. Brenner

submission deadline 31 Jan 2026 | Viewed by 37 | Submission Open

Keywords: HIV; antiretroviral therapy (ART); pre-exposure prophylaxis (PrEP); antiviral drugs; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viruses in the Reproductive Tract

edited by

Mimi Ghosh

Raina Nakova Fichorova

and Christina Farr

submission deadline 31 Jan 2026 | Viewed by 35 | Submission Open

Keywords: reproductive tract virome; viruses in pregnancy; virus infections and adverse fetal health; virus-associated malignancies of the reproductive tract; immune response to viruses of the reproductive tract; antiviral biomarkers; antiviral vaccines and drugs; hormonal regulation of virus infections

(This special issue belongs to the Section General Virology)

Baculovirus as Vaccine Vectors, RNA Interference Mediators, and Gene Delivery Vectors: 2nd Edition

edited by

Hung-Jen Liu

submission deadline 31 Jan 2026 | Viewed by 30 | Submission Open

Keywords: baculovirus; vaccine vectors; subunit vaccine; baculovirus display vectors; RNA interference mediators; gene delivery vectors

(This special issue belongs to the Section Invertebrate Viruses)

Rift Valley Fever Virus: New Insights into a One Health Archetype

edited by

Rebekah C. Kading

, Juliette Lewis and Brian H. Bird

submission deadline 31 Jan 2026 | Viewed by 8 | Submission Open

Keywords: One Health; emerging infectious diseases; mosquito; bunyavirus; arbovirus; medical entomology; medical countermeasures; livestock

(This special issue belongs to the Section Animal Viruses)

Insect-Specific Viruses and Biological Control of Arboviruses

edited by

Valéria Lima Carvalho

and

Carlos A.M. Carvalho

submission deadline 6 Feb 2026 | Viewed by 120 | Submission Open

Keywords: insect-specific virus; mosquito-specific virus; arbovirus; evolution; vaccine; biological control; interference

(This special issue belongs to the Section Invertebrate Viruses)

Infectious Disease Epidemiology: Current Updates and Perspectives

edited by

Agata Skrzat-Klapaczynska

and

Justyna Dominika Kowalska

submission deadline 10 Feb 2026 | Viewed by 11 | Submission Open

Keywords: infection prevention and control; infectious diseases epidemiology; public health; novel treatments

(This special issue belongs to the Section General Virology)

PANoptosis in Viral Infection

edited by

Thirumala-Devi Kanneganti

submission deadline 28 Feb 2026 | 4 articles | Viewed by 9498 | Submission Open

Keywords: • Viruses• Inflammation• PANoptosis• PANoptosome

(This special issue belongs to the Section General Virology)

Pharmacology of Antiviral Drugs, 2nd Edition

edited by

David E. Martin

submission deadline 28 Feb 2026 | 1 articles | Viewed by 614 | Submission Open

Keywords: pharmacology; clinical pharmacology; antiviral therapy; antiviral prophylaxis; human viruses; animal viruses; pharmacokinetics; pharmacodynamics; drug resistance

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Endogenous Retrovirus Proteins and Their Functions, 2nd Edition

edited by

Benoit Barbeau

submission deadline 28 Feb 2026 | Viewed by 404 | Submission Open

Keywords: endogenous retrovirus; ERV envelope protein; receptor; cell fusion; cancer; pre-eclampsia; obstetric disorder; diagnosis; evolutionary conservation; gene regulation

(This special issue belongs to the Section Human Virology and Viral Diseases)

Foot-and-Mouth Disease Virus

edited by

Satya Parida

and

Zhidong Zhang

submission deadline 28 Feb 2026 | Viewed by 60 | Submission Open

Keywords: foot-and-mouth disease; foot-and-mouth disease virus; hoof-and-mouth disease; FMD; FMD virus; foot-and-mouth disease vaccines

(This special issue belongs to the Section Animal Viruses)

HIV Accessory Proteins

edited by

Gail E. Fanucci

submission deadline 28 Feb 2026 | Viewed by 50 | Submission Open

Keywords: accessory proteins; cellular interactions; drug design; liquid– liquid phase separations; molecular condensate; HIV; novel accessory proteins from other viruses

(This special issue belongs to the Section General Virology)

Food-Associated and Foodborne Viruses: A Food Safety Concern or Tool?

edited by

Ningbo Liao

, Daofeng Liu and

Hao Yan

submission deadline 28 Feb 2026 | Viewed by 18 | Submission Open

Keywords: foodborne viruses; norovirus epidemiology; viral zoonoses; phage biocontrol; food viromics; virus detection technologies

(This special issue belongs to the Section General Virology)

Nuclear Architecture in Viral Infection

edited by Veronica Sanchez and Elizabeth White

submission deadline 28 Feb 2026 | Viewed by 8 | Submission Open

Keywords: nuclear architecture; viral transcription; viral replication; viral assembly

(This special issue belongs to the Section General Virology)

Chronic Infection by Oncogenic Viruses 2.0

edited by

Christophe Nicot

submission deadline 28 Feb 2026 | Viewed by 6 | Submission Open

Keywords: virus transmission; virus replication; virus pathogenesis; virus latency; virus– host interactions; antiviral immune responses; virus-induced cellular transformation; antiviral drugs and vaccines

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Host-Targeting Antivirals: From Mechanism to Intervention

edited by

Stephan Pleschka

submission deadline 28 Feb 2026 | Viewed by 1 | Submission Open

Keywords: host-targeting antivirals; host receptors; signaling pathways; metabolic networks; transcription factors; treatment; clinical intervention practice; preclinical data; intervention strategy design; mechanism

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Mpox (Monkeypox): From Neglected Tropical Disease to Emerging Global Pathogen

edited by

David A. Schwartz

Robert Colebunders

and Patrick Katoto

submission deadline 1 Mar 2026 | 10 articles | Viewed by 18067 | Submission Open

Keywords: monkeypox; mpox; monkeypox virus; mpxv; poxvirus; Poxviridae; Africa; DR Congo; outbreak; epidemic; stillbirth; sexual transmission; vaccination; emerging infection

(This special issue belongs to the Section Human Virology and Viral Diseases)

Epidemiology, Pathogenesis and Immunity of Adenovirus

edited by Adriana Kajon and

Jay R. Radke

submission deadline 6 Mar 2026 | 3 articles | Viewed by 2054 | Submission Open

Keywords: human adenovirus; viral infection; pathogenesis; epidemiology; immune response; diagnosis; therapeutics; vaccine development

(This special issue belongs to the Section Human Virology and Viral Diseases)

Hepatitis Viral Infections, Pathogenesis and Therapeutics (2nd Edition)

edited by

Fan Zhu

submission deadline 31 Mar 2026 | Viewed by 129 | Submission Open

Keywords: hepatitis A virus (HAV); hepatitis B virus (HBV); hepatitis C virus (HCV); hepatitis D virus (HDV); hepatitis E virus (HEV); chronic liver disease; chronic hepatitis; liver cirrhosis; hepatocellular carcinoma (HCC); liver cancer; antiviral therapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Tick-Borne Viruses 2026

edited by

Pat Nuttall

submission deadline 31 Mar 2026 | Viewed by 111 | Submission Open

Keywords: tick-borne viruses; vector-borne pathogens; virus– tick– host interactions; saliva-assisted transmission; tick exosomes; tick antiviral mechanisms; virus evolution; surveillance

(This special issue belongs to the Section General Virology)

Viral Non-Structural Proteins

edited by

Giuseppe Sautto

submission deadline 31 Mar 2026 | Viewed by 61 | Submission Open

Keywords: viral genome; non-structural proteins; virus replication; vaccines; viral therapeutics

(This special issue belongs to the Section General Virology)

Porcine Epidemic Diarrhea Virus (PEDV): A Persistent Threat to the Global Swine Industry

edited by

Ke Liu

submission deadline 31 Mar 2026 | Viewed by 43 | Submission Open

Keywords: porcine epidemic diarrhea virus; global epidemiology; economic loss; vaccines and drugs; molecular mechanism; transmission and pathogenic mechanisms

(This special issue belongs to the Section Animal Viruses)

HPV-Associated Cancers 2025

edited by Diane M. Harper

submission deadline 31 Mar 2026 | Viewed by 24 | Submission Open

Keywords: HPV; cervical cancer; head and neck cancer; penile cancer; cancer prevention; targeted therapy; cancer stem cells; molecular study; carcinogenesis; immunotherapy

(This special issue belongs to the Section Human Virology and Viral Diseases)

Japanese Encephalitis Virus and Other Closely Related Clinically Important Orthoflaviviruses—A Persistent Threat to Public and Animal Health

edited by

Ke Liu

submission deadline 31 Mar 2026 | Viewed by 20 | Submission Open

Keywords: Japanese encephalitis virus; mosquito-borne; orthoflaviviruses; public and animal health; transmission; infection; host

(This special issue belongs to the Section General Virology)

Advances in HSV

edited by Susmit Suvas and James Chodosh

submission deadline 31 Mar 2026 | Viewed by 17 | Submission Open

Keywords: HSV-1; HSV-2; latency; herpes epithelial keratitis; herpes stromal keratitis; HSV vaccine; herpes simplex encephalitis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Molecular Epidemiology, Evolution, and Dispersion of Flaviviruses (2nd Edition)

edited by

Marta Giovanetti

Fernanda De Bruycker Nogueira

Ana Maria Bispo De Filippis

and

Anne Paiva

submission deadline 30 Apr 2026 | 4 articles | Viewed by 9612 | Submission Open

Keywords: flavivirus; evolution; genomic epidemiology; phylodynamics; transmission

(This special issue belongs to the Section Animal Viruses)

Plant Virus Resistance—2nd Edition

edited by

Miguel A. Aranda

submission deadline 30 Apr 2026 | Viewed by 47 | Submission Open

Keywords: plant virus resistance mechanisms; resistance-breaking viral strains; genetic and molecular breeding; virus– host interactions; genome editing; virus susceptibility factors; plant virus ecology; plant virus host range

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Epidemiology of Zoonotic Virus Transmission: Pathways, Host Factors, and Public Health Strategies

edited by

Francisco José Nunes Antunes

and

Rita Cordeiro

submission deadline 30 Apr 2026 | Viewed by 40 | Submission Open

Keywords: zoonotic viruses; transmission pathways; host factors; public health strategies; one health

(This special issue belongs to the Section Animal Viruses)

Human T-Cell Leukemia Virus (HTLV) Infection and Treatment 2.0

edited by Cynthia A. Pise-Masison and Damian F. J. Purcell

submission deadline 30 Apr 2026 | Viewed by 13 | Submission Open

Keywords: HTLV; HTLV-associated myelopathy/tropical spastic paraparesis; adult T-cell leukemia/lymphoma; inflammation; neurodegeneration; therapeutics; infectious dermatitis; cancer; antiviral drugs

(This special issue belongs to the Section Human Virology and Viral Diseases)

Coxsackieviruses, Polioviruses and Associated Diseases (Second Edition)

edited by

Yong Zhang

and

Didier Hober

submission deadline 1 May 2026 | 10 articles | Viewed by 9512 | Submission Open

Keywords: coxsackievirus; HFMD; viral Meningitis; myocarditis; pericarditis; herpangina; poliovirus; poliomyelitis; acute flaccid paralysis; post-polio syndrome; pleurodynia (Bornholm disease)

(This special issue belongs to the Section Human Virology and Viral Diseases)

Control and Contributions of Transposable Elements: Implications for Development and Disease

edited by Suzanne B. Sandmeyer and Henry L. Levin

submission deadline 1 May 2026 | Viewed by 189 | Submission Open

Keywords: transposable elements; endogenous viruses; transcription factors; neurotransmission; aging

(This special issue belongs to the Section General Virology)

Viral Genetic Variability and Its Role in Assessing Infectious Diseases

edited by

Fabio Scarpa

and

Francesco Branda

submission deadline 6 May 2026 | Viewed by 129 | Submission Open

Keywords: viral genetic diversity; infectious diseases; viral evolution; host adaptation; next-generation sequencing; pathogenicity; immune evasion; viral surveillance; bioinformatics; genetic variability; phylogeny; phylodynamics

(This special issue belongs to the Section General Virology)

Influenza B Virus: From Infection to Prevention

edited by Saira Hussain

submission deadline 30 May 2026 | Viewed by 198 | Submission Open

Keywords: influenza B viruses; epidemiology; evolution; pathogenesis; immunity; vaccine; antivirals

(This special issue belongs to the Section Animal Viruses)

Emerging and Re-Emerging Viral Zoonoses

edited by

Lorena Jemeršić

and

Margarida Simões

submission deadline 31 May 2026 | 1 articles | Viewed by 293 | Submission Open

Keywords: epidemiology of emerging and re-emerging viral zoonoses; zoonotic spillover; viral evolution; animal reservoirs; zoonotic transmission; animals as sentinels of viral zoonoses and risk analyses; diagnostic novelties and early detection of viral threats; viral genomics and molecular epidemiology; viral pathogenesis; viral adaptation mechanisms; wildlife– human interface; monkeypox virus (mpxv); influenza viruses; nipah virus; ebola/marburg virus; hantavirus; crimea-congo virus; vaccine development; therapeutic and mitigation strategies; climate change; biodiversity loss and infectious diseases

(This special issue belongs to the Section Animal Viruses)

West Nile Virus 2025

edited by Orsolya Korbacska-Kutasi

submission deadline 31 May 2026 | Viewed by 75 | Submission Open

Keywords: West Nile virus; epidemiology; surveillance; biology; evolution; pathogenesis; vaccine development; antiviral therapies

(This special issue belongs to the Section Animal Viruses)

Oropouche Virus (OROV): An Emerging Peribunyavirus (Bunyavirus)

edited by

David A. Schwartz

and

André Ricardo Ribas Freitas

submission deadline 1 Jun 2026 | 7 articles | Viewed by 15163 | Submission Open

Keywords: oropouche fever; oropouche virus; bunyavirus; epidemic; travel infection; pregnancy complications; stillbirth; microcephaly; brazil; Latin America; emerging virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Humoral Immune Response to Viruses

edited by Haiyan Zhao

submission deadline 6 Jun 2026 | Viewed by 54 | Submission Open

Keywords: broadly neutralizing antibodies; protective antibodies; non-protective antibodies; epitopes; epitope-based vaccine design; B cell development; B cell repertoire; immune memory; vaccine development; plasma cells; antibody-based therapies

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Discovery, Classification, and Early Research on the Lipid-Containing, Double-Stranded RNA Bacteriophage φ6

edited by

Paul Gottlieb

and Aleksandra Alimova

submission deadline 15 Jun 2026 | 7 articles | Viewed by 20136 | Submission Open

Keywords: procapsid; nucleocapsid; polymerase complex; assembly; replication; recombination; packaging10

(This special issue belongs to the Section Bacterial Viruses)

Emerging and Re-Emerging Neuroinvasive Arboviruses

edited by

Rafael Freitas de Oliveira França

Rodrigo Stabeli

and Mylena R. Pereira

submission deadline 16 Jun 2026 | Viewed by 84 | Submission Open

Keywords: arbovirus; innate immune response; adaptive immune response; epidemiology; diagnosis; prevention; vaccine; animal model; pathogenesis; viral evolution; in vitro; in vivo

(This special issue belongs to the Section Animal Viruses)

Immune Responses to Papillomavirus Infections: 2nd Edition

edited by

Jiafen Hu

submission deadline 30 Jun 2026 | 2 articles | Viewed by 2367 | Submission Open

Keywords: papillomavirus; HPV; immune responses; infections; models

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Infection and Platelets’ Disorders

edited by

Pierpaolo Di Micco

Alessandro Perrella

and

Giuseppe Camporese

submission deadline 30 Jun 2026 | Viewed by 357 | Submission Open

Keywords: viral infections; thrombosis; thrombotic microangiopathies; disseminated intravascular coagulation; low molecular weight heparin; bleedings; acute infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

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