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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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HIV Reservoirs, Latency, and the Factors Responsible

edited by Yuyang Tang and

Mudit Tyagi

submission deadline 31 Dec 2025 | 5 articles | Viewed by 23197 | Submission Open

Keywords: HIV; HIV latency; HIV persistence; HIV eradication; HIV cure; HIV vaccine

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Infections and Immune Dysregulation 2024–2025

edited by

Ester Ballana Guix

and

Ifeanyi Jude Ezeonwumelu

submission deadline 31 Dec 2025 | 6 articles | Viewed by 19468 | Submission Open

Keywords: immune responses; immune dysregulation; autoimmunity; viral infections; immunomodulation

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Microscopy Methods for Virus Research

edited by Krishanu Ray

submission deadline 31 Dec 2025 | 7 articles | Viewed by 18798 | Submission Open

Keywords: viruses; fluorescence imaging; single-molecule imaging; super-resolution imaging; intra-vital imaging; electron microscopy; Cryo-EM; Cryo-ET

(This special issue belongs to the Section General Virology)

Controlling Zoonotic Viral Diseases from One Health Perspective 2025

edited by

Maureen T. Long

and Erika Schwarz-Collins

submission deadline 31 Dec 2025 | 5 articles | Viewed by 16457 | Submission Open

Keywords: one health; viral zoonoses; control; vaccine; surveillance; epidemiology

(This special issue belongs to the Section Animal Viruses)

EBV and Disease: New Perspectives in the Post COVID-19 Era

edited by

Xiaoming Lyu

and Dengke Li

submission deadline 31 Dec 2025 | 7 articles | Viewed by 13066 | Submission Open

Keywords: EBV; reactivation and immune dysregulation; EBV-associated malignancies; autoimmune diseases; diagnostic and therapeutic

(This special issue belongs to the Section Human Virology and Viral Diseases)

Preparation for the Next Potential Pandemic—Chikungunya, Dengue, Zika and Other Viruses

edited by

Zoltan Vajo

submission deadline 31 Dec 2025 | 6 articles | Viewed by 11701 | Submission Open

Keywords: chikungunya; dengue; zika; next pandemic; epidemiology; pharmaceutics; immunology

(This special issue belongs to the Section Human Virology and Viral Diseases)

H5N1 Influenza Viruses

edited by

Daniel R. Perez

submission deadline 31 Dec 2025 | 6 articles | Viewed by 10780 | Submission Open

Keywords: H5N1; avian influenza; genetic diversity; immune response; vaccines and antiviral therapies

(This special issue belongs to the Section Animal Viruses)

Natural, Semisynthetic, and Synthetic Antiviral Drugs Targeting HIV and SARS-CoV-2

edited by

Otávio Augusto Chaves

and

Carlos Serpa

submission deadline 31 Dec 2025 | 5 articles | Viewed by 10191 | Submission Open

Keywords: antiviral design and discovery; natural product screening; natural products as a scaffold for semisynthetic antivirals; repurposing drugs; high-throughput screening; antiviral resistance; biophysical characterization of the interaction between antivirals and targets; combination of light and photosensitizers in antiviral discovery; cell-based and in vivo assays; in silico calculations

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

SARS-CoV-2, COVID-19 Pathologies, Long COVID, and Anti-COVID Vaccines

edited by

Jean-Marc Sabatier

submission deadline 31 Dec 2025 | 5 articles | Viewed by 9580 | Submission Open

Keywords: SARS-CoV-2; COVID-19; long COVID; anti-COVID vaccines; spikeopathy; renin– angiotensin system

(This special issue belongs to the Section Coronaviruses)

Application of Genetically Engineered Plant Viruses

edited by

Tsung-Chi Chen

submission deadline 31 Dec 2025 | 4 articles | Viewed by 7733 | Submission Open

Keywords: plant virus; infectious clone; viral vector; virus-induced gene silencing (VIGS); virus-like particles (VLPs); cross-protection

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Molecular Biomarkers for Viral Infection

edited by

Paulina Niedźwiedzka-Rystwej

submission deadline 31 Dec 2025 | 3 articles | Viewed by 7695 | Submission Open

Keywords: molecular biomarkers; viral infections

(This special issue belongs to the Section Animal Viruses)

Interplay Between Influenza Virus and Host Factors

edited by

Matloob Husain

submission deadline 31 Dec 2025 | 4 articles | Viewed by 5608 | Submission Open

Keywords: influenza virus; host factors; proviral host factors; antiviral host factors; host adaptation; virus entry; virus assembly; virus release; innate antiviral response; interferon-stimulated genes; post-translational protein modifications

(This special issue belongs to the Section Animal Viruses)

Lung Immunity to Viral Infections

edited by

Ana Paula Duarte De Souza

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4476 | Submission Open

Keywords: respiratory virus; lung immune response; vaccines to respiratory virus; microbiota and lung immune response; environmental factors and lung immune responses; virus– host interaction in the lung; immunotherapies to prevent or treat respiratory viral infection

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Molecular Virus–Insect Interactions, 2nd Edition

edited by Li-Long Pan

submission deadline 31 Dec 2025 | 3 articles | Viewed by 4278 | Submission Open

Keywords: plant virus-insect vector interactions; virus transmission; entomopathogenic virus-insect host interactions; insect-specific viruses; induction and suppression of immune responses

(This special issue belongs to the Section Invertebrate Viruses)

Emerging Microbes, Infections and Spillovers, 2nd Edition

edited by

Ravi Kant

Tarja Sironen

and

Maciej Grzybek

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4211 | Submission Open

Keywords: emerging infections; virus spillovers; microbes; cross-species transmission; virus evolution; viral disease; virus reservoirs; virus– host interaction; pathogenesis

(This special issue belongs to the Section Animal Viruses)

Surveillance, Transmission Dynamics, and Control of Zoonotic Viruses

edited by Dimitrios A. Chatzidimitriou,

Anna Papa

and Ilias Bouzalas

submission deadline 31 Dec 2025 | 2 articles | Viewed by 4172 | Submission Open

Keywords: zoonosis; surveillance; epidemiology; diagnostics

(This special issue belongs to the Section Animal Viruses)

Advancing Hepatitis Elimination: HBV, HDV, and HCV

edited by

Federico García

submission deadline 31 Dec 2025 | 4 articles | Viewed by 4133 | Submission Open

Keywords: hepatitis elimination; HBV; HCV; HDV

(This special issue belongs to the Section Human Virology and Viral Diseases)

Severe Fever with Thrombocytopenia Syndrome Virus 2025

edited by

Masayuki Saijo

submission deadline 31 Dec 2025 | 2 articles | Viewed by 3995 | Submission Open

Keywords: SFTS; SFTSV; emerging viral infections

(This special issue belongs to the Section Human Virology and Viral Diseases)

Porcine Viruses 2025

edited by

Guoxin Li

Lingxue Yu

and

Jin Cui

submission deadline 31 Dec 2025 | 6 articles | Viewed by 3968 | Submission Open

Keywords: epidemiology; pathogenesis; immune evasion; virus evolution; vaccine

(This special issue belongs to the Section Animal Viruses)

Viral Diseases of Sheep and Goats

edited by Ramsés Reina and Álex Gómez

submission deadline 31 Dec 2025 | 3 articles | Viewed by 3361 | Submission Open

Keywords: small ruminants; viral immunopathogenesis; infection; transmission; epidemiology; control strategies; vaccines

(This special issue belongs to the Section Animal Viruses)

Antiviral Development for Emerging and Re-Emerging Viruses

edited by

Ming-Hon Hou

and

Shih-Chao Lin

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2829 | Submission Open

Keywords: protein– protein interaction; viral– host interaction; viral replication; antiviral; human viruses; emerging infections

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Animal Virus Discovery and Genetic Diversity: 2nd Edition

edited by

Ryan Troyer

submission deadline 31 Dec 2025 | 3 articles | Viewed by 2753 | Submission Open

Keywords: animal virus; evolution; genetic; diversity; richness; emerging viruses; virome; metagenomics; ecology; cross-species transmission; zoonotic

(This special issue belongs to the Section Animal Viruses)

Human Hepatitis Viruses and Their Animal Homologues

edited by

Bo Wang

and

Xinglou Yang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2702 | Submission Open

Keywords: hepatitis viruses; animal virome; genetic diversity; genomic organization; ecology and evolution; molecular biology; molecular epidemiology; zoonotic potential

(This special issue belongs to the Section General Virology)

Viral Strategies and Cellular Countermeasures That Regulate mRNA Access to the Translation Apparatus: 2nd Edition

edited by

Christopher U. T. Hellen

submission deadline 31 Dec 2025 | 2 articles | Viewed by 2365 | Submission Open

Keywords: virus– host interactions; IRES elements; RNA structure; translation initiation; translational control; innate immune response; RNA modification

(This special issue belongs to the Section General Virology)

Coronavirus Pathogenesis and Virus-Host Interaction

edited by

Hin Chu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 2226 | Submission Open

Keywords: COVID-19; SARS-CoV-2; SARS-CoV-1; MERS-CoV; pathogenesis; virus– host interaction; virus entry; host factors; animal models; SARS-CoV-2 variants

(This special issue belongs to the Section General Virology)

Zika Virus and Congenital Zika Syndrome, 2nd Edition

edited by Marcos Vinicius da Silva Pone and Sheila Moura Pone

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1885 | Submission Open

Keywords: viral infections; Zika virus; congenital Zika syndrome

(This special issue belongs to the Section Human Virology and Viral Diseases)

Early Diagnosis and Surveillance of Transboundary and Emerging Viral Diseases of Animals, 2nd Edition

edited by

Aruna Ambagala

and

Kalhari Goonewardene

submission deadline 31 Dec 2025 | 2 articles | Viewed by 1836 | Submission Open

Keywords: diagnostics; surveillance; transboundary; emerging; animal diseases; virus; detection; validation; novel; sample types; alternative

(This special issue belongs to the Section Animal Viruses)

Harnessing AI and Machine Learning for Antiviral Development

edited by

X. Frank Zhang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1796 | Submission Open

Keywords: artificial intelligence; machine learning; antiviral therapies; personalized medicine; drug discovery; drug repurposing; drug resistance

(This special issue belongs to the Section General Virology)

Oncogenic Infections and Cancer: Clinical Insights and Emerging Therapeutics

edited by G. Hossein Ashrafi and Mustafa Ozdogan

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1591 | Submission Open

Keywords: oncogenesis; viral oncology; bacterial oncogenesis; human papillomavirus (HPV); Epstein– Barr virus (EBV); Kaposi’ s sarcoma-associated herpesvirus (KSHV); hepatitis B virus (HBV); hepatitis C virus (HCV); human T-lymphotropic virus (HTLV-1); Helicobacter pylori; infection-driven cancers; molecular mechanisms; tumor microenvironment; immunotherapy; viral persistence; antiviral therapies; CRISPR-based treatments; cancer prevention; vaccine development; immune checkpoint inhibitors; diagnostic biomarkers; personalized medicine; translational oncology; therapeutic resistance; emerging therapeutics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virological and Immunological Factors Underlying HBV Functional Cure and HBV Reactivation

edited by

Valentina Svicher

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1466 | Submission Open

Keywords: HBV persistence; HBV functional cure; cccDNA; immunology of HBV; HBV reactivation; immune-escape mutations

(This special issue belongs to the Section Human Virology and Viral Diseases)

Picornavirus Evolution, Host Adaptation and Antiviral Strategies

edited by

Leyi Wang

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1435 | Submission Open

Keywords: virus evolution; new picornavirus; variant picornavirus; host adaptation; vaccine immunization; antiviral drugs

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virology and Immunology of Gene Therapy 2025

edited by Weidong Xiao and

Jianming Qiu

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1413 | Submission Open

Keywords: gene therapy; viral vector; vaccine; immune responses; viruses; AAV; lentiviral vectors; neutralizing antibody

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Cyanophage and Algal Virus

edited by

Rodrigo Araújo Lima Rodrigues

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1324 | Submission Open

Keywords: cyanophages; algal viruses; Algavirales; Phycodnaviridae; Marnaviridae; aquatic virus; algae bloom; viral diversity; viral ecology

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Current: Measles Outbreak, a Global Situation

edited by

S. Louise Cosby

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1261 | Submission Open

Keywords: measles; vaccination; surveillance; complications; outbreaks

(This special issue belongs to the Section Human Virology and Viral Diseases)

Arboviruses and Climate, 2nd Edition

edited by José Lourenço and

Marta Giovanetti

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1090 | Submission Open

Keywords: arbovirus; climate; climate change; arthropods; vectors; epidemiology; evolution; ecology; public health

(This special issue belongs to the Section Invertebrate Viruses)

Viral Immunology in Transplant Patients

edited by

Alessandro Perrella

submission deadline 31 Dec 2025 | 1 articles | Viewed by 1010 | Submission Open

Keywords: viral infections; transplant patients; immunocompromised; immune response; host– pathogen interactions; immunotherapies; diagnostic approaches; preventive strategies

(This special issue belongs to the Section Human Virology and Viral Diseases)

The Structure and Function of Flavivirus Genes and Proteins

edited by

Tadahisa Teramoto

and Kay Choi

submission deadline 31 Dec 2025 | 1 articles | Viewed by 947 | Submission Open

Keywords: flavivirus; structural protein; non-structural protein; 5'UTR; 3'UTR

(This special issue belongs to the Section General Virology)

Phage Display in Cancer Diagnosis and Screening

edited by

Valery A. Petrenko

submission deadline 31 Dec 2025 | 1 articles | Viewed by 835 | Submission Open

Keywords: phage display; cancer; diagnosis; screening; prognosis and monitoring

(This special issue belongs to the Section Bacterial Viruses)

Virus Bioinformatics 2025

edited by

Manja Marz

and

Maria Fabisch

submission deadline 31 Dec 2025 | Viewed by 661 | Submission Open

Keywords: virus bioinformatics; software; viral metagenomics and ecology; virus– host interactions; viral diversity and evolution; virus identification

(This special issue belongs to the Section General Virology)

Antigenic Drift in Respiratory Viruses

edited by

Gabriel Gonzalez

submission deadline 31 Dec 2025 | 1 articles | Viewed by 476 | Submission Open

Keywords: respiratory viruses; virus diversity; viral recombination; reassortment; zoonotic viruses; wastewater pathogen surveillance; viral sequencing; virus evolutionary characterization; animal viruses

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advancing Research of Anelloviruses, Second Edition

edited by

Fabrizio Maggi

and

Pietro Giorgio Spezia

submission deadline 31 Dec 2025 | Viewed by 452 | Submission Open

Keywords: TTV; TTMV; TTMDV; virome; viral species; immune system; orphan virus

(This special issue belongs to the Section Human Virology and Viral Diseases)

RNA Viruses Replication and Innate Immunity

edited by

Griffith Parks

submission deadline 31 Dec 2025 | Viewed by 390 | Submission Open

Keywords: RNA virus replication and transcription; pathogen-associated molecular patterns; interferons; cytokines; signaling pathways

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Virus Biosensing

edited by Guobin Mao

submission deadline 31 Dec 2025 | Viewed by 372 | Submission Open

Keywords: virus detection; molecular diagnosis; immunoassay; nucleic acid amplification; CRISPR-based detection; nucleic acid assembly; biosensor; point-of-care testing

(This special issue belongs to the Section General Virology)

Tackling Viral Resistance—Advances in Mechanisms, Detection, and Control

edited by

Nuno Taveira

and Claudia Palladino

submission deadline 31 Dec 2025 | Viewed by 312 | Submission Open

Keywords: viral resistance; antiviral therapies; drug resistance mechanisms; epidemiology; diagnostic advancements; clinical management

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Modeling Zoonotic and Vector-Borne Viruses in Evolving Ecological Systems

edited by

Salihu S. Musa

, Sani Isah Abba and Ismail Abdulrashid

submission deadline 31 Dec 2025 | Viewed by 293 | Submission Open

Keywords: zoonotic viruses; vector-borne diseases; climate change and disease dynamics; epidemiological modeling; outbreak forecasting and control; human behavior; virus– host– vector interactions

(This special issue belongs to the Section Animal Viruses)

Experimental Animal and Organoid-Based Lethal Virus Infection Models for Human, Companion Animals and Livestock

edited by

Tomomi Takano

submission deadline 31 Dec 2025 | Viewed by 246 | Submission Open

Keywords: organoid models; experimental animals; lethal virus infections; pathogenesis; vaccine development; therapeutic drugs; in vitro models; in vivo models; human viral infections; companion animal viral infections; livestock viral infections; viral infection models; ferret; hamster; transgenic mouse

(This special issue belongs to the Section General Virology)

Spotlight on Bocavirus and Other Parvoviruses, and Overlooked Respiratory Viruses

edited by

Suncanica Ljubin‐Sternak

and

Tatjana Vilibic-Cavlek

submission deadline 31 Dec 2025 | Viewed by 223 | Submission Open

Keywords: bocavirus; Parvovirus B19; canine parvovirus; porcine parvovirus; metapneumovirus; rhinovirus Planned Papers 1. Molecular detection of Porcine cytomegalovirus (PCMV) and Porcine parvovirus (PPV) in domestic pigs and wild boars from Croatia 2. Protoparvovirus carnivoran 1 outbreak in golden jackals in Croatia 3. Epidemiology of parvovirus B19 in Croatian childbearing-aged women: A ten-year seroprevalence study

(This special issue belongs to the Section Animal Viruses)

Virus Infection Fate Regulation

edited by Andreas Meyerhans and

Gennady Bocharov

submission deadline 31 Dec 2025 | Viewed by 174 | Submission Open

Keywords: virus infection fate; dynamics; immune response; cellular response; regulation

(This special issue belongs to the Section General Virology)

Interferon-Stimulated Genes in Antiviral Immunity

edited by

Chen Liang

submission deadline 31 Dec 2025 | Viewed by 153 | Submission Open

Keywords: interferon-stimulated genes; ISGs; non-coding RNA; viral replication; deep learning tools

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Innovative Drug Discovery for Emerging Viral Diseases, 2nd Edition

edited by Chaoping Chen

submission deadline 31 Dec 2025 | Viewed by 111 | Submission Open

Keywords: antivirals; drug discovery; high-throughput screen; SARS-CoV-2; influenza virus; RSV; zika; ebola virus; chikungunya virus; emerging/re-emerging RNA viral pathogens; host-directed therapies; immunomodulator

(This special issue belongs to the Section General Virology)

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