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Viruses publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Strategies for the Discovery of Antivirals Against Respiratory RNA Viruses 2026

edited by Yuanwei Pan, Badri Parshad and

Xinyi Liu

submission deadline 31 Jul 2026 | Viewed by 59 | Submission Open

Keywords: antiviral discovery; respiratory RNA viruses; drug repurposing; high-throughput screening; nanomaterials-based antivirals; antiviral drug delivery; viral polymerase inhibitors; preclinical models

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Dual Nature of Bacteriophages: Friends or Enemies in the Food Industry?—2nd Edition

edited by

Michał Wójcicki

Barbara Sokolowska

and

Ewa Jończyk-Matysiak

submission deadline 31 Jul 2026 | Viewed by 52 | Submission Open

Keywords: bacteriophages; biocontrol; biosensors; food safety; foodborne bacterial pathogens; food quality; foodborne saprophytic bacteria

(This special issue belongs to the Section Bacterial Viruses)

Recent Advances in Antiviral Natural Products, 2nd Edition

edited by

Massimiliano Galdiero

Carla Zannella

Annalisa Chianese

and

Rosa Giugliano

submission deadline 31 Jul 2026 | Viewed by 49 | Submission Open

Keywords: virus; antiviral; natural product; antimicrobial peptides; drug delivery; infectious disease

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Intrinsic Immunity vs. Viral Antagonism: Which One Bites the Dust?

edited by

Akatsuki Saito

and

Kenzo Tokunaga

submission deadline 31 Jul 2026 | Viewed by 44 | Submission Open

Keywords: host restriction factors; viral antagonists; replication cycle; interferon-inducible pathways; ubiquitination; membrane trafficking

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

The 13th Wisc-e-sota Symposium

edited by

Louis M. Mansky

and

Paul F. Lambert

submission deadline 31 Jul 2026 | Viewed by 33 | Submission Open

Keywords: HIV; retrovirus; adeno-associated virus; Epstein– Barr virus; pichinde virus; porcine reproductive and respiratory syndrome virus

(This special issue belongs to the Section General Virology)

The Role of Adjuvants in Viral Vaccines and Vaccination

edited by

Zoltan Vajo

submission deadline 31 Jul 2026 | Viewed by 10 | Submission Open

Keywords: aluminum hydroxide; oil-in-water emulsion adjuvants; TLR agonists; combination adjuvants

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Viruses 2026—New Horizons in Virology

edited by

Eric O. Freed

and

Albert Bosch

submission deadline 1 Aug 2026 | Viewed by 721 | Submission Open

Keywords: virus; replication; assembly; pathogenesis; outbreak; molecular biology; cell biology; public health; structural biology

(This special issue belongs to the Section General Virology)

Immune Modulation by Human Cytomegalovirus: 2nd Edition

edited by

Davide Abate

submission deadline 1 Aug 2026 | Viewed by 103 | Submission Open

Keywords: human cytomegalovirus (CMV); molecular and cellular mechanisms; cell-intrinsic immunity; adaptive immunity; innate immunity

(This special issue belongs to the Section Human Virology and Viral Diseases)

2nd Edition: How to Adjust the Action Steps for Achieving the Global Hepatitis Virus (HBV/HCV/HDV) Elimination Targets?

edited by Ferruccio Bonino

submission deadline 31 Aug 2026 | 1 articles | Viewed by 1182 | Submission Open

Keywords: antivirals; chronic viral hepatitis infections; HBV; HBV; functional cure; HCV; HCV vaccine; HDV; HDV-RNA; anti-HD

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Rotaviruses and Rotavirus Vaccines: 2nd Edition

edited by

Lijuan Yuan

and

Viviana Parreño

submission deadline 31 Aug 2026 | Viewed by 152 | Submission Open

Keywords: rotaviruses; molecular biology; reverse genetics; molecular epidemiology; vaccine development; human intestinal organoid models

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Gene Therapy in the Fight Against Viral Infections and Related Diseases: Innovations, Challenges and Future Perspectives

edited by

Michele Lai

and

Alessandro De Carli

submission deadline 31 Aug 2026 | Viewed by 108 | Submission Open

Keywords: gene therapy; viral infections; gene delivery systems; viral vectors; non-viral vectors; gene editing; CRISPR/Cas systems; antiviral therapy vector engineering; targeted delivery; tissue-specific targeting; host– pathogen interactions; CAR-T

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

CRISPR Applications in Plant Virology

edited by

Jian Wu

submission deadline 31 Aug 2026 | Viewed by 91 | Submission Open

Keywords: CRISPR/Cas9; plant virology; virus resistance; genome editing; plant breeding; viral evolution; CRISPR applications; host– virus interactions; crop protection; genome modification

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Seed-Borne and Seed-Transmitted Virus

edited by Qinsheng Gu

submission deadline 31 Aug 2026 | Viewed by 81 | Submission Open

Keywords: seed-borne virus; seed-transmitted virus; management; detection

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Insights into Feline Viruses: Molecular, Structural, Pathogenic, and Clinical Aspects

edited by

Barbara Di Martino

submission deadline 31 Aug 2026 | Viewed by 38 | Submission Open

Keywords: cats; feline viruses; emerging viruses; molecular virology; pathogenesis; clinical virology; molecular and serological diagnostics; metagenomics; therapeutic and control strategies; One Health

(This special issue belongs to the Section Animal Viruses)

Hepatitis Viruses in Pathogenesis: Chronic Infection to Hepatocellular Carcinoma

edited by

Giraud Guillaume

submission deadline 31 Aug 2026 | Viewed by 34 | Submission Open

Keywords: hepatocellular carcinoma; chronic infection; viral hepatitis; liver pathogenesis; biomarkers

(This special issue belongs to the Section Human Virology and Viral Diseases)

Virus Discovery: Innovative Approaches to Detection and Characterization of Emerging Viruses

edited by

Steve Wylie

submission deadline 31 Aug 2026 | Viewed by 15 | Submission Open

Keywords: virus detection; virus assay; emerging viruses; virus threats; cryptic viruses

(This special issue belongs to the Section General Virology)

Mechanisms of Herpesvirus Resistance

edited by

Graciela Andrei

submission deadline 1 Sep 2026 | 3 articles | Viewed by 5677 | Submission Open

Keywords: human herpesviruses; cytomegalovirus; drug resistance; antiviral agents; immunocompromised host; novel anti-herpesvirus therapies; DNA polymerase; terminase

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Coronaviruses Pathogenesis, Immunity, and Antivirals (2nd Edition)

edited by

Wentao Li

and Fei Yu

submission deadline 30 Sep 2026 | 9 articles | Viewed by 13879 | Submission Open

Keywords: coronavirus; pathogenesis; molecular; vaccines; evolution; immunity; antivirals

(This special issue belongs to the Section Coronaviruses)

Pestivirus 2025

edited by

Benjamin J. Lamp

and Christiane M. Riedel

submission deadline 30 Sep 2026 | 3 articles | Viewed by 3675 | Submission Open

Keywords: pestiviruses; classical swine fever virus; bovine viral diarrhea virus; BVDV-1; BVDV-2; CSF

(This special issue belongs to the Section Animal Viruses)

The Structure and Function of Flavivirus Genes and Proteins

edited by

Tadahisa Teramoto

and Kay Choi

submission deadline 30 Sep 2026 | 1 articles | Viewed by 1331 | Submission Open

Keywords: flavivirus; structural protein; non-structural protein; 5'UTR; 3'UTR

(This special issue belongs to the Section General Virology)

The Entry and Fusion of Enveloped Virus

edited by

Tsutomu Murakami

submission deadline 30 Sep 2026 | Viewed by 188 | Submission Open

Keywords: enveloped virus; entry; attachment; virus binding; membrane fusion; internalization; endocytosis; uncoating; intracellular trafficking; nuclear import; receptor; carbohydrates; antiviral; neutralizing antibody; vaccine

(This special issue belongs to the Section General Virology)

Wastewater-Based Epidemiology and Viral Surveillance

edited by

Elisabetta Carraro

Cristina Pignata

and

Silvia Bonetta

submission deadline 30 Sep 2026 | Viewed by 134 | Submission Open

Keywords: wastewater‐based epidemiology; WBE; viral surveillance; virus shedding; sewage; viral dynamics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Unraveling Human Herpesviruses: From Molecular Mechanisms to Antiviral Approaches

edited by

Christopher B. Whitehurst

submission deadline 30 Sep 2026 | Viewed by 105 | Submission Open

Keywords: human herpesviruses; post-translational modifications; epigenetics; cancer; molecular mechanisms; antivirals; protein interactions

(This special issue belongs to the Section Human Virology and Viral Diseases)

3D Models in Viral Pathogenesis

edited by

David C. Bloom

Leonardo D'Aiuto

and Elizabeth Fortunato

submission deadline 30 Sep 2026 | Viewed by 99 | Submission Open

Keywords: organoids; viral pathogenesis; mini-brains; 3D culture; viruses; in vitro models

(This special issue belongs to the Section General Virology)

Coronaviruses: Variants, Antivirals, and Vaccination

edited by

Cheng-Wen Lin

submission deadline 30 Sep 2026 | Viewed by 60 | Submission Open

Keywords: coronavirus variants; SARS-CoV-2 evolution; antivirals; vaccination; immune response; global health; viral pathogenesis; public health preparedness; host genomics; monoclonal antibodies

(This special issue belongs to the Section Coronaviruses)

Coronavirus Therapy: Antiviral Drugs and Anti-Inflammatory Immunopharmacology

edited by

Chengyuan Liang

Lei Tian

and

Mengzhou Wang

submission deadline 30 Sep 2026 | Viewed by 55 | Submission Open

Keywords: coronavirus therapeutics; antiviral target; host-directed antivirals; immunomodulation; diagnostics; prevention; antiviral resistance; AI-driven drug discovery

(This special issue belongs to the Section Coronaviruses)

Viruses Associated with Gastroenteritis: 2nd Edition

edited by

Celso Cunha

and

Claudia Istrate

submission deadline 30 Sep 2026 | Viewed by 24 | Submission Open

Keywords: vaccines; therapeutic approaches; virus replication; molecular epidemiology; immune response; microbiome; diagnosis

(This special issue belongs to the Section Human Virology and Viral Diseases)

Re-Emergence of Yellow Fever Virus

edited by Rosemary Sang

submission deadline 30 Sep 2026 | Viewed by 15 | Submission Open

Keywords: yellow fever virus; Flavivirus; mosquito-borne transmission; viral evolution; outbreak expansion; vaccination challenges; molecular epidemiology; control strategies

(This special issue belongs to the Section Human Virology and Viral Diseases)

Common Pathogenic Mechanisms of Plant Viruses

edited by

Yen-Wen Kuo

submission deadline 30 Sep 2026 | Viewed by 11 | Submission Open

Keywords: plant viruses; viral pathogenicity; host– virus interactions; viral replication; virus movement; suppression of RNA silencing; plant immunity; conserved mechanisms; molecular virology

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Imaging Neurotropic Viruses

edited by

Elena Criscuolo

and Salla Mattola

submission deadline 30 Sep 2026 | Viewed by 2 | Submission Open

Keywords: neurotropic viruses; neuroinvasion; immune evasion; host– virus interactions; neuronal models; organoids; live-cell microscopy; microfuidics

(This special issue belongs to the Section General Virology)

Zoonotic and Vector-Borne Viral Diseases: 2nd Edition

edited by

Nariman Shahhosseini

submission deadline 1 Oct 2026 | 1 articles | Viewed by 547 | Submission Open

Keywords: vector-borne viral diseases (VBVDs); vector– host– pathogen interactions; emerging and re-emerging; zoonotic diseases; vectors or reservoirs; vaccine development; and prevention and control measures; One Health

(This special issue belongs to the Section Animal Viruses)

Genetic and Epigenetic Regulation of Virus–Host Interaction

edited by

Litao Sun

submission deadline 1 Oct 2026 | Viewed by 72 | Submission Open

Keywords: virus– host interaction; epigenetic regulation; genetic variation; antiviral immunity; post-translational modification; RNA virus; viral infection; host defense response

(This special issue belongs to the Section General Virology)

Enteric Viruses in Environment and Humans: Identification, Surveillance and Control

edited by

Rita De Cássia Compagnoli Carmona

and Maria Inês Zanoli Sato

submission deadline 30 Oct 2026 | 3 articles | Viewed by 2599 | Submission Open

Keywords: enteric viruses; wastewater-based epidemiology; human-based epidemiology; One Health

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advances in Endemic and Emerging Viral Diseases in Livestock: 2nd Edition

edited by

Fernando Vicosa Bauermann

and

Mayara Maggioli

submission deadline 30 Oct 2026 | 1 articles | Viewed by 1289 | Submission Open

Keywords: veterinary virology; livestock; ruminants; swine; vaccines

(This special issue belongs to the Section Animal Viruses)

Advances in Animal Influenza Virus Research 2026

edited by

Jansen Araujo

submission deadline 30 Oct 2026 | Viewed by 240 | Submission Open

Keywords: animal influenza viruses; avian influenza virus; H5N1; viral evolution; viral reassortment; zoonotic potential transmission; diagnostics advances; molecular epidemiology and vaccine development

(This special issue belongs to the Section Animal Viruses)

Influenza and Other Respiratory Viruses: Prevention, Diagnosis, Treatment: 3rd Edition

edited by

Eric Yager

submission deadline 31 Oct 2026 | 1 articles | Viewed by 334 | Submission Open

Keywords: influenza; adenovirus; coronoavirus; respiratory syncytial virus; rhinovirus; respiratory virus; antiviral strategies; epidemiology; diagnosis; treatment; vaccination; surveillance; vaccine development

(This special issue belongs to the Section Animal Viruses)

Early ART Initiation: Impacts on Viral Dynamics and Clinical Outcomes

edited by

Alessandra Vergori

Andrea De Vito

and

Vincenzo Malagnino

submission deadline 31 Oct 2026 | Viewed by 97 | Submission Open

Keywords: early antiretroviral therapy; HIV viral dynamics; immune recovery; viral reservoir; clinical outcomes; HIV transmission

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

Diagnostics, Antiviral Therapy and Vaccination Against Orthopoxvirus Infections (2nd Edition)

edited by

Sergei N. Shchelkunov

submission deadline 31 Oct 2026 | Viewed by 77 | Submission Open

Keywords: orthopoxvirus; monkeypox; smallpox; vaccinia; antiviral drugs; next-generation vaccines; molecular diagnostics; viral evolution; outbreak

(This special issue belongs to the Section Animal Viruses)

2A and 2A-Like Sequences in Viruses: Function, Mechanism and Biotechnological/Biomedical Applications

edited by Martin Ryan and Garry Luke

submission deadline 31 Oct 2026 | Viewed by 67 | Submission Open

Keywords: virus protein biogenesis; ribosome ‘ skipping’ ; protein co-expression; biotechnology; biomedicine

(This special issue belongs to the Section General Virology)

Plant Protection and Resistance to Viruses

edited by

Patrick Materatski

and

Carla Varanda

submission deadline 31 Oct 2026 | Viewed by 26 | Submission Open

Keywords: plant viruses; plant viral diseases; plant protection; plant– virus interactions; host defense mechanisms; RNA interference; virus-induced gene silencing; plant virus detection and epidemiology; host resistance; sustainable disease management; plant– virus– environment interactions

(This special issue belongs to the Section Viruses of Plants, Fungi and Protozoa)

Neurocognitive Dynamics and Biomarkers in HIV

edited by Mattia Trunfio and Carmela Pinnetti

submission deadline 1 Nov 2026 | 2 articles | Viewed by 2704 | Submission Open

Keywords: HIV infection; neurodegeneration; biomarkers; neuroinflammation; cognitive performance; mood; central nervous system

(This special issue belongs to the Section Human Virology and Viral Diseases)

Advances in Rabies Research 2025–2026

edited by Juan A. Montaño-Hirose and

Charles E. Rupprecht

submission deadline 30 Nov 2026 | Viewed by 378 | Submission Open

Keywords: rabies; zoonosis; vaccine; evolution; structural biology; viral replication; virus– host interaction; pathogenesis and immunity; clinical virology

(This special issue belongs to the Section General Virology)

Respiratory Viral Pathogenesis and Host-Microbe Crosstalk: From Bench to Bedside

edited by Shenghai Huang and

Theo J. Moraes

submission deadline 1 Dec 2026 | 2 articles | Viewed by 1685 | Submission Open

Keywords: respiratory viruses; pathogenesis; host– microbe crosstalk; etiological diagnosis; prevention and treatment; RSV; influenza; coronavirus

(This special issue belongs to the Section Human Virology and Viral Diseases)

Viral Surveillance, Transmission, Pathogenesis, and Vaccine Development in Domestic Animals and Wildlife

edited by

Jieshi Yu

Feng Li

and Wen-Kang Wei

submission deadline 1 Dec 2026 | 1 articles | Viewed by 840 | Submission Open

Keywords: animal viruses; influenza viruses; coronaviruses; rotaviruses; transmission; epidemiology; surveillance; pathogenesis; one health; vaccine; domestic animals; wildlife; emerging viruses; re-emerging viruses

(This special issue belongs to the Section Animal Viruses)

Molecular and Cellular Biology of Human Oncogenic Viruses: 2nd Edition

edited by

Roberta Gonnella

submission deadline 1 Dec 2026 | 1 articles | Viewed by 591 | Submission Open

Keywords: oncoviruses; antiviral drugs; viral oncogenesis; viral infection; oncogenic pathways; epigenetics

(This special issue belongs to the Section Human Virology and Viral Diseases)

Human and Animal Papillomavirus: Infections, Genetics, and Vaccines (2nd Edition)

edited by

Antonio Carlos de Freitas

and

Anna Silva

submission deadline 10 Dec 2026 | Viewed by 87 | Submission Open

Keywords: papillomavirus (PV); vaccines; infection biology; genetics; HPV and nongenital cancer; molecular epidemiology; bioinformatics; oncogenesis; HPV and cancer; animal papillomavirus and associated diseases

(This special issue belongs to the Section Human Virology and Viral Diseases)

Bioinformatics and Computational Approaches in Viral Genomics and Evolution 2025–2026

edited by Camila Malta Romano, Mariana Severo Ramundo and Nilson Coimbra

submission deadline 16 Dec 2026 | 4 articles | Viewed by 5837 | Submission Open

Keywords: bioinformatics tools; genomic surveillance; viral evolution; computational genomics; host-pathogen interactions

(This special issue belongs to the Section General Virology)

Advances in Research on Emerging and Zoonotic Diseases

edited by Vladimir Stevanović and

Tatjana Vilibic-Cavlek

submission deadline 30 Dec 2026 | Viewed by 51 | Submission Open

Keywords: emerging infectious diseases; zoonoses; epidemiology; pathogenesis; diagnostics

(This special issue belongs to the Section Animal Viruses)

Advances in Respiratory Viruses Research: From Basic Studies to Public Health

edited by Anna Puigdellívol-Sánchez

submission deadline 30 Dec 2026 | Viewed by 51 | Submission Open

Keywords: respiratory viruses; SARS-CoV-2 co-variants; virus-host interaction; genetic susceptibility; host genetic factors; immune response; wastewater surveillance; seasonal vaccines; differential diagnosis; long COVID; COVID-19 sequelae

(This special issue belongs to the Section Viral Immunology, Vaccines, and Antivirals)

BSL4 Viruses: Understanding and Controlling Highly Infectious Pathogens, 2nd Edition

edited by Courtney B. Woolsey

submission deadline 30 Dec 2026 | Viewed by 47 | Submission Open

Keywords: virus– host; viral life cycle; viral replication; pathogenesis; epidemiology; medical countermeasures; antivirals; Ebola virus; Marburg virus; Lassa virus; Nipah virus; Hendra virus; Crimean– Congo hemorrhagic fever virus; arenaviruses; paramyxoviruses; Nairo viruses; filoviruses; hemorrhagic fever virus

(This special issue belongs to the Section Animal Viruses)

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