Neurocognitive Dynamics and Biomarkers in HIV
A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".
Deadline for manuscript submissions: 1 November 2025 | Viewed by 508
Special Issue Editors
Interests: neuroHIV; CSF biomarkers; cognitive disorders; central nervous system infections; CNS virome; neuroinflammation; HIV reservoir
Interests: neuroHIV; HIV-associated neurocognitive disorders; HIV-associated dementia; clinical pharmacology of antiretrovirals; neurotoxicity; CSF viral escape
Special Issue Information
Dear Colleagues,
HIV infection, both in and outside the central nervous system (CNS), can lead to significant neuroinflammation, which is intricately linked to various clinical consequences, including mood disorders, cognitive decline, and neurodegeneration. The mechanisms underlying these effects are complex and multifaceted, involving factors such as aging, comorbidities, co-infections, pharmacological contributions, substance use disorders, systemic inflammation, and HIV persistence in the CNS. As we navigate this landscape, innovative techniques are emerging, e.g., ultrasensitive assays for molecular biomarkers, proteomics, transcriptomics, and advanced imaging methods. New approaches for analyzing the complexity and granularity of the data generated by these techniques are also expanding, such as advanced clustering methods and AI-integrated machine learning.
This Special Issue will focus on the diagnostic and prognostic value of biomarkers of any type—such as molecular, genetic/epigenetic, imaging, and microbial—in relation to the brain and mental health of people living with HIV. It will encompass original research, reviews, and case studies that highlight the latest findings in this field. Our goal is to illuminate the complex interplay between HIV infection and persistence, neuroinflammation, and neurocognitive dysfunction while fostering interdisciplinary approaches that integrate clinical insights with cutting-edge research. By bringing together diverse perspectives, we aim to enhance our understanding of these critical issues and inform the development of targeted interventions that improve outcomes for those living with HIV. We invite contributions to advance our collective knowledge and stimulate further research in this important area.
Dr. Mattia Trunfio
Dr. Carmela Pinnetti
Guest Editors
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- HIV infection
- neurodegeneration
- biomarkers
- neuroinflammation
- cognitive performance
- mood
- central nervous system
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