Molecular and Cellular Biology of Human Oncogenic Viruses: 2nd Edition

A special issue of Viruses (ISSN 1999-4915). This special issue belongs to the section "Human Virology and Viral Diseases".

Deadline for manuscript submissions: 1 December 2026 | Viewed by 1447

Special Issue Editor


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Guest Editor
Department of Experimental Medicine, Sapienza University of Rome, Viale Regina Elena 324, 00161 Rome, Italy
Interests: herpesviruses; EBV; KSHV; virus replication; autophagy
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Special Issue Information

Dear Colleagues,

The number of oncovirus-associated cancers has been increasing in recent years; it has been estimated that approximately 10% of neoplastic diseases in the world correlate with viral infections. Therefore, understanding the molecular mechanisms through which oncoviruses regulate viral and host gene expression may help in identifying potential therapeutic targets. There are currently seven recognized viruses associated with human cancer, namely EBV, KSHV, HPV, HTLV-1, HBV, HCV, and MCV. They are able to infect different cell types and can adopt similar and specific strategies to trigger the transformation of their target cells.

The aim of this Special Issue is to provide new insights into the mechanisms underlying viral oncogenesis in the attempt to identify new drugs, enabling the manipulation of the viral lytic cycle, which, in some cases, can be latent or lytic, or target the epigenetic changes and the activation of pro-oncogenic molecular pathways that oncoviruses may induce. The study of mechanisms leading to the establishment of viral infections may also provide useful information on cancer prevention, including the development of vaccines against oncoviruses.

Publications from the first volume can be found here: https://www.mdpi.com/journal/viruses/special_issues/Human_Oncogenic_Viruses.

We are looking forward to receiving your contributions.

Dr. Roberta Gonnella
Guest Editor

Manuscript Submission Information

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Keywords

  • oncoviruses
  • antiviral drugs
  • viral oncogenesis
  • viral infection
  • oncogenic pathways
  • epigenetics

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Published Papers (1 paper)

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Review

8 pages, 909 KB  
Review
Roles of Macrophage Migration Inhibitory Factor (MIF) Signaling Pathway in Oncovirus Infection and Virus-Associated Cancers
by Jiaojiao Fan, Victor Ryu, Zhiqiang Qin and Lu Dai
Viruses 2025, 17(12), 1582; https://doi.org/10.3390/v17121582 - 5 Dec 2025
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Abstract
Approximately 12% of all human cancers are caused by oncoviruses. Macrophage migration inhibitory factor (MIF) signaling activation has been found closely related to many cancer cell malignant behaviors and infectious disease progression. However, its role in virus-associated cancers or how oncoviruses may regulate [...] Read more.
Approximately 12% of all human cancers are caused by oncoviruses. Macrophage migration inhibitory factor (MIF) signaling activation has been found closely related to many cancer cell malignant behaviors and infectious disease progression. However, its role in virus-associated cancers or how oncoviruses may regulate MIF signaling activities remains largely unknown. In the current review, we summarize recent findings about the oncovirus activation of MIF signaling pathways, their functional roles in viral oncogenesis, and the development of MIF-targeted therapies. We also discuss future directions in this interesting field. Full article
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