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Volume 7
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Review

Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family

by
Shu Hui Wong
1,2,†,
Alagie Jassey
3,†,
Jonathan Y. Wang
1,
Wei-Cheng Wang
4,
Ching-Hsuan Liu
4,5 and
Liang-Tzung Lin
4,6,*
1
International Master Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
2
Institut de Recherches Cliniques de Montréal, Montreal, QC H2W 1R7, Canada
3
International Ph.D. Program in Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
4
Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
5
Department of Microbiology & Immunology, Dalhousie University, Halifax, NS B3H 4R2, Canada
6
Department of Microbiology and Immunology, School of Medicine, College of Medicine, Taipei Medical University, Taipei 11031, Taiwan
*
Author to whom correspondence should be addressed.
†
These authors share first authorship.
Vaccines 2019, 7(4), 123; https://doi.org/10.3390/vaccines7040123
Submission received: 15 August 2019 / Revised: 7 September 2019 / Accepted: 13 September 2019 / Published: 20 September 2019
(This article belongs to the Special Issue Current Flavivirus Research Important for Vaccine Development )
Versions Notes

Abstract

Viruses in the Flaviviridae family are important human and animal pathogens that impose serious threats to global public health. This family of viruses includes emerging and re-emerging viruses, most of which are transmitted by infected mosquito or tick bites. Currently, there is no protective vaccine or effective antiviral treatment against the majority of these viruses, and due to their growing spread, several strategies have been employed to manufacture prophylactic vaccines against these infectious agents including virus-like particle (VLP) subunit vaccines. VLPs are genomeless viral particles that resemble authentic viruses and contain critical repetitive conformational structures on their surface that can trigger the induction of both humoral and cellular responses, making them safe and ideal vaccine candidates against these viruses. In this review, we focus on the potential of the VLP platform in the current vaccine development against the medically important viruses in the Flaviviridae family.
Keywords: virus-like particles; Flaviviridae; immunogenicity; vaccines virus-like particles; Flaviviridae; immunogenicity; vaccines

Share and Cite

MDPI and ACS Style

Wong, S.H.; Jassey, A.; Wang, J.Y.; Wang, W.-C.; Liu, C.-H.; Lin, L.-T. Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family. Vaccines 2019, 7, 123. https://doi.org/10.3390/vaccines7040123

AMA Style

Wong SH, Jassey A, Wang JY, Wang W-C, Liu C-H, Lin L-T. Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family. Vaccines. 2019; 7(4):123. https://doi.org/10.3390/vaccines7040123

Chicago/Turabian Style

Wong, Shu Hui, Alagie Jassey, Jonathan Y. Wang, Wei-Cheng Wang, Ching-Hsuan Liu, and Liang-Tzung Lin. 2019. "Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family" Vaccines 7, no. 4: 123. https://doi.org/10.3390/vaccines7040123

APA Style

Wong, S. H., Jassey, A., Wang, J. Y., Wang, W.-C., Liu, C.-H., & Lin, L.-T. (2019). Virus-Like Particle Systems for Vaccine Development against Viruses in the Flaviviridae Family. Vaccines, 7(4), 123. https://doi.org/10.3390/vaccines7040123

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