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Endocrine Disruptors Exposure, Toxicity and Health Risk Assessment

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A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Human Toxicology and Epidemiology".

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 5088

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Special Issue Editors

Dr. Mingqing Chen

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Guest Editor

Life Sciences, Central China Normal University, Wuhan 430079, China
Interests: endocrine disruptor; phthalic acid bis (2 ethylhexyl) ester; plasticizers; ankyrins; cation channel; thermoreceptors; indoor air pollution; diisobutyl phthalate; volatile organic compounds

Dr. Wenqian Huo

E-Mail Website
Guest Editor

Department of Occupational and Environmental Health, College of Public Health, Zhengzhou University, Zhengzhou, China
Interests: cardiovascular disease; air quality; ultrafine particulate matter; bisphenol S; lexan; phenol; sex hormone-binding globulin; non insulin dependent diabetes mellitus

Special Issue Information

Dear Colleagues,

Endocrine disruptor chemicals (EDs), also known as environmental hormones, are substances that exist in the environment that can interfere with human and animal endocrine systems and cause abnormal effects. EDs have been identified as emerging contaminants which pose a great threat to human health and ecosystem. EDs can induce dysregulation of the body’s development, reproduction, metabolism, immune system and nervous system, and can even cause behavioral disorders. The scientific knowledge on EDs is still growing and the assessment of exposure, toxicity, and health risk for EDs is still evolving. This Special Issue focuses on the impacts of EDs on the human health and ecosystem, including exposure source identification, the health effects, and the toxicity mechanisms of EDs. We invite the submission of original research articles and review articles on these topics, and we look forward to receiving your updated insights.

Research areas may include (but are not limited to) the following:

Exposure of humans and the environment to EDs, as well as modelling and experimental approaches for characterizing the exposure.
EDs exposure and effects on animal and human health: disorders-associated development, reproduction, metabolic diseases, immune system, nervous system, bone tissue and behavior.
Interaction and biological effects between EDs and other pollutants.
Environmental impact of EDs: the damage they do to ecosystems, the environmental tolerance level and species differences.
EDs toxicological mechanism: mechanisms and mode of action of EDs with in vitro and in vivo toxicity testing.

Dr. Mingqing Chen
Dr. Wenqian Huo
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

endocrinal disruptors
environmental hormones
environmental toxicology
toxicological effect
toxicological mechanism
risk assessment
plasticizers

Published Papers (3 papers)

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Research

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13 pages, 1164 KiB

Open AccessFeature PaperArticle

Exposure Profile and Characteristics of Parabens and Alkylphenols in Plasma among Rural Adults in Central China

by Qian Gao, Changsheng Huan, Yu Song, Zexin Jia, Qingqing Cao, Chongjian Wang, Zhenxing Mao and Wenqian Huo

Toxics 2023, 11(11), 926; https://doi.org/10.3390/toxics11110926 - 13 Nov 2023

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Abstract

Parabens and alkylphenols pose serious hazards to human health, yet there are few studies on their exposure profiles and health risks in rural Chinese populations. In this study, 804 participants were selected from the Henan Rural Cohort in mid-eastern China. The plasma levels of parabens (methylparaben, ethylparaben, propylparaben, butylparaben (BuP)) and alkylphenols (4-tert-butylphenol (4-t-BP), 4-tert-octylphenol (4-t-OP)) were analyzed via liquid chromatography–tandem mass spectrometry. Linear regression models were used to investigate factors that may influence pollutant exposure levels. The correlation between contaminants was assessed using Spearman’s correlation. The human contaminant intake was estimated using the estimated daily intake (EDI). The health risk was assessed using the hazard quotient (HQ). The detection frequency of four parabens and two alkylphenols exceeded 75%, with median concentrations of 0.444, 0.067, 0.078, 0.053, 8.810, and 6.401 ng/mL, respectively. Significant correlations were observed between parabens, as well as between 4-t-BP and 4-t-OP. Regarding gender, paraben concentrations were higher in women than in men, except for BuP. The EDI for pollutants except 4-t-OP was lower than their respective tolerable/acceptable daily intake. In total, 85.70% of participants had 4-t-OP HQ > 1. A widespread exposure to parabens and alkylphenols among the rural population was found. The high health risks of alkylphenol exposure indicate that alkylphenols should be used with caution. Full article

(This article belongs to the Special Issue Endocrine Disruptors Exposure, Toxicity and Health Risk Assessment)

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15 pages, 7145 KiB

Open AccessArticle

Acetyl Tributyl Citrate Exposure at Seemingly Safe Concentrations Induces Adverse Effects in Different Genders of Type 2 Diabetes Mice, Especially Brain Tissue

by Yuchao Zhang, Zhihuai Zhang, Sijie Zhu, Liangyu Liu, Xudong Liu and Xu Yang

Toxics 2023, 11(10), 877; https://doi.org/10.3390/toxics11100877 - 23 Oct 2023

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Abstract

Acetyl tributyl citrate (ATBC) is a widely used phthalate substitute. Although ATBC is considered to be with a safe dosage of up to 1000 mg/kg/day, studies on its effects in some sensitive populations, such as diabetic patients, are relatively rare. Epidemiological studies have shown that there is a link between diabetes and nervous system diseases. However, toxicological studies have not fully confirmed this yet. In this study, glycolipid metabolism, cognitive deficits, brain tissue damage, levels of neurotransmitters, beta-amyloid plaques (Aβ), hyperphosphorylated tau protein (p-Tau), oxidative stress and inflammation, as well as glial cell homeostatic levels in the brain tissue of type 2 diabetes (T2DM) mice, were determined after ATBC exposure (0, 2, 20, and 200 mg/kg/day) for 90 days. The results confirmed that ATBC exposure aggravated the disorder of glycolipid metabolism and caused cognitive deficits in T2DM mice; induced histopathological alterations and Aβ and p-Tau accumulation, and reduced the levels of 5-hydroxytryptamine and acetylcholine in T2DM mouse brains; oxidative stress and glial cell homeostatic levels in T2DM mouse brains were also changed. Some of the adverse effects were gender-dependent. These findings support the theory that T2DM mice, especially males, are more sensitive to ATBC exposure. Although the safe dose of ATBC is high, prolonged exposure at seemingly safe concentrations has the potential to aggravate diabetes symptoms and cause brain tissue damage in T2DM mice. Full article

(This article belongs to the Special Issue Endocrine Disruptors Exposure, Toxicity and Health Risk Assessment)

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Review

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28 pages, 2658 KiB

Open AccessReview

Pancreas–Liver–Adipose Axis: Target of Environmental Cadmium Exposure Linked to Metabolic Diseases

by Diana Moroni-González, Victor Enrique Sarmiento-Ortega, Alfonso Diaz, Eduardo Brambila and Samuel Treviño

Toxics 2023, 11(3), 223; https://doi.org/10.3390/toxics11030223 - 26 Feb 2023

Cited by 6 | Viewed by 2474

Abstract

Cadmium has been well recognized as a critical toxic agent in acute and chronic poisoning cases in occupational and nonoccupational settings and environmental exposure situations. Cadmium is released into the environment after natural and anthropogenic activities, particularly in contaminated and industrial areas, causing food pollution. In the body, cadmium has no biological activity, but it accumulates primarily in the liver and kidney, which are considered the main targets of its toxicity, through oxidative stress and inflammation. However, in the last few years, this metal has been linked to metabolic diseases. The pancreas–liver–adipose axis is largely affected by cadmium accumulation. Therefore, this review aims to collect bibliographic information that establishes the basis for understanding the molecular and cellular mechanisms linked to cadmium with carbohydrate, lipids, and endocrine impairments that contribute to developing insulin resistance, metabolic syndrome, prediabetes, and diabetes. Full article

(This article belongs to the Special Issue Endocrine Disruptors Exposure, Toxicity and Health Risk Assessment)

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