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Toxics
Special Issues
Reproductive and Developmental Toxicity of Environmental Factors
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Reproductive and Developmental Toxicity of Environmental Factors

A special issue of Toxics (ISSN 2305-6304). This special issue belongs to the section "Reproductive and Developmental Toxicity".

Deadline for manuscript submissions: 31 July 2025 | Viewed by 2019

Special Issue Editors

Dr. Tao Chen

E-Mail Website
Guest Editor
School of Public Health, Medical College of Soochow University, Suzhou, China
Interests: cardiac developmental toxicity; emerging contaminants; epigenetics; DNA damage
Special Issues, Collections and Topics in MDPI journals
Prof. Dr. Jisheng Nie

E-Mail Website
Guest Editor
Department of Occupational and Environmental Health, School of Public Health, Shanxi Medical University, Xinjiannan Road 56, Taiyuan 030001, China
Interests: neurodevelomental toxicity; polycyclic aromatic hydrocarbons; epigenetics; DNA damage
Prof. Dr. Jie Zhang

E-Mail Website
Guest Editor
Department of Toxicology, School of Public Health, Medical College of Soochow University, Suzhou, China
Interests: developmental toxicity; chronotoxicology; EDCs; epigenetics

Special Issue Information

Dear Colleagues,

Developmental periods are highly sensitive to various environmental factors, including environmental pollutants, nutrients, and other stressors. The developing heart and brain are particularly vulnerable to these influences, making early life a critical window for assessing toxic exposures. Environmental contaminants can also compromise reproductive capability. Understanding the reproductive and developmental toxicity of environmental factors is essential for evaluating their impact on human health and ecosystems, as well as for effective risk assessment and management.

In the Special Issue “Reproductive and Developmental Toxicity of Environmental Factors”, we aim to explore the incidence, effects, and mechanisms of environmental factors on fertility and prenatal/postnatal development. We invite you to submit high-quality original research papers, short communications, and reviews on the reproductive and developmental toxicity of environmental agents. Topics of interest include, but are not limited to, the following:

  1. Reproductive and developmental toxicity mechanisms of traditional or emerging contaminants;
  2. The impact of environmental factors on fertility and reproductive health;
  3. The relationship between maternal exposure to environmental factors and abortion or congenital diseases;
  4. Protective and intervention strategies against the reproductive and developmental toxicity of environmental factors.

Dr. Tao Chen
Prof. Dr. Jisheng Nie
Prof. Dr. Jie Zhang
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Toxics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • reproductive and developmental toxicity
  • environmental pollutants
  • risk assessment
  • environmental epidemiology
  • protective and intervention strategies

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

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Research

21 pages, 564 KiB  
Article
Air Pollution Exposure and Gestational Diabetes Mellitus Risk: A Retrospective Case–Control Study with Multi-Pollutant Analysis in Wuhan, Hubei Province
by Mengyang Dai, Jianfeng Liu, Min Hu, Feng Zhang, Yanjun Wang, Fangfang Dai, Rui Qu, Zhixiang Fang and Jing Yang
Toxics 2025, 13(2), 141; https://doi.org/10.3390/toxics13020141 - 19 Feb 2025
Viewed by 551
Abstract
Ambient air pollution has been associated with gestational diabetes mellitus (GDM); however, evidence regarding trimester-specific effects from China remains limited. This case–control study study analyzed data from pregnant women who delivered in Wuhan, China, between 2017 and 2022 (164 GDM cases and 731 [...] Read more.
Ambient air pollution has been associated with gestational diabetes mellitus (GDM); however, evidence regarding trimester-specific effects from China remains limited. This case–control study study analyzed data from pregnant women who delivered in Wuhan, China, between 2017 and 2022 (164 GDM cases and 731 controls), integrating geographic information, air quality measurements, and maternal characteristics. Using Inverse Distance Weighting interpolation and Generalized Linear Mixed Models (GLMM), we assessed associations between air pollutant exposure and GDM across different gestational periods. Results indicated that NO2 demonstrated the strongest association with GDM compared to other pollutants. Specifically, increased NO2 exposure was consistently associated with higher GDM risk throughout pregnancy. PM2.5 exposure showed significant associations during early and mid-pregnancy, while SO2 exposure was significantly associated with GDM risk exclusively in early pregnancy. Sensitivity analyses stratified by urban maternity status and maternal age revealed the stability of the study’s findings. These findings underscore the importance of reducing air pollution exposure during pregnancy and implementing targeted interventions for high-risk populations to prevent GDM development. Full article
(This article belongs to the Special Issue Reproductive and Developmental Toxicity of Environmental Factors)
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14 pages, 1735 KiB  
Article
Association Between Fine Particle Waves and Sexual Function: A Nationwide Cross-Sectional Survey in China
by Weiqian Zhang, Rui Qu, Guan Cheng, Jingxuan Wang, Tailang Yin, Jue Liu, Dongdong Tang and Yan Zhang
Toxics 2025, 13(1), 39; https://doi.org/10.3390/toxics13010039 - 6 Jan 2025
Cited by 1 | Viewed by 1034
Abstract
Background: The effect of the long-term persistently elevated air pollutants, often referred to as air pollution waves, on sexual function has not been sufficiently addressed. Methods: This nationwide cross-sectional study involved 12,157 participants, with 5496 females and 5039 males. PM waves were characterized [...] Read more.
Background: The effect of the long-term persistently elevated air pollutants, often referred to as air pollution waves, on sexual function has not been sufficiently addressed. Methods: This nationwide cross-sectional study involved 12,157 participants, with 5496 females and 5039 males. PM waves were characterized by daily average PM concentrations surpassing Grade II thresholds of China’s ambient air quality standards (PM2.5 > 75 μg/m3, PM10 > 150 μg/m3) for three or more consecutive days (3–8 days). Male sexual function was assessed through the International Index of Erectile Function-5 (IIEF-5) and the Premature Ejaculation Diagnostic Tool (PEDT), while female sexual function was evaluated using the Female Sexual Function Index (FSFI). A multivariate linear regression model was employed to investigate the link between PM wave exposure and sexual function. Results: Exposure to PM10 waves, defined as 3 (β = −0.0145, 95%CI = −0.0280, −0.0010), 4 (β = −0.0145, 95%CI = −0.0280, −0.0010), 5 (β = −0.0193, 95%CI = −0.0371, −0.0015), 6 (β = −0.0218, 95%CI = −0.0415, −0.0021), 7 (β = −0.0243, 95%CI = −0.0458, −0.0028), and 8 (β = −0.0243, 95%CI = −0.0458, −0.0028) consecutive days, negatively impacted IIEF-5 scores and male sexual function. Moreover, depression levels, as evaluated by the PHQ-9, played a mediating role in the connection between PM10 waves and IIEF-5 scores. The potentially vulnerable subgroups were the younger 20–30 and the low-income groups. Conclusions: Our results suggest for the first time that PM10 waves are associated with decreased IIEF-5 scores, which are mediated by depression score PHQ-9, informing policy formulation for public health interventions and individual safeguarding. Full article
(This article belongs to the Special Issue Reproductive and Developmental Toxicity of Environmental Factors)
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