Polymer-Based Matrices for Drug Delivery: In Vitro, In Vivo and In Silico Approaches
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".
Deadline for manuscript submissions: closed (25 August 2022) | Viewed by 30809
Special Issue Editors
Interests: nanotechnology; biomedical engineering; materials science; electrospinning; electrowriting; 3D printing; microparticles; computational mathematics
Special Issues, Collections and Topics in MDPI journals
Interests: materials science; drug delivery; micro/nano encapsulation; biomolecule characterization
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In recent years, a great deal of effort has been focused on drug delivery systems within the biomedical field. In this scenario, polymer-based systems (for example, microparticles, nanoparticles or microneedles) are recognized as very popular carriers and are specifically designed to deliver the encapsulated active molecules to a specific targeting site, achieving improved therapeutic effects and reduced adverse effects. The reason behind this great diffusion is several attractive features, such as the use of non-laborious techniques, low production costs, simplicity in industrial scale-up, and possibilities of different ways of administration (trans-epidermal, oral, ocular, parental, inhalation).
Together with the empirical approach, theoretical and mathematical models represent a fundamental tool to optimally design new pharmaceutical systems, study drug formulations and evaluate in vitro and in vivo releases. In this regard, the shape and dimension of the system designed to achieve a specific drug release profile as well as the amount and type of the active agent, adjuvants and polymer can be predicted, in order to obtain a fine control on the drug release kinetics and to provide a personalized therapy. Moreover, in silico models can help to more deeply understand the physical and chemical mechanisms of drug release, also reducing the number of experiments.
The aim of this Special Issue is to underline and collect research progresses and outputs in nano- and microencapsulation techniques related to the drug delivery field, including both in vivo and in vitro studies. Articles that describe in silico models to predict physicochemical properties and release profiles are also welcome.
Dr. Valentina Onesto
Dr. Concetta Di Natale
Guest Editors
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Keywords
- microparticles
- nanoparticles
- microneedles
- in vitro
- in silico
- mathematical models
- drug encapsulation
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