Recent Advances in Marine Origin Compound-Based Formulation with Anti-inflammatory Properties

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: closed (30 September 2022) | Viewed by 3054

Special Issue Editors


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Guest Editor
Murmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), Vladimirskaya, 17, Murmansk 183010, Russia
Interests: brown algae; extraction; natural deep eutectic solvents; fucoidan; polyphenols; alginic acid; laminaran; phloroglucinol; mannitol; fucoxanthin; drug delivery system; bioavailability; HPLC
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E-Mail Website
Guest Editor
Murmansk Marine Biological Institute of the Russian Academy of Sciences (MMBI RAS), Vladimirskaya, 17, Murmansk 183010, Russia
Interests: algae; controlled release; extraction; green solvents; hydrobionts; fucoidan; mechanisms of action; polyphenols; pharmacokinetics; analysis

Special Issue Information

Dear Colleagues,

Compounds from marine organisms of various taxa form a pool of molecules that are unique in structure and properties and have enormous medicinal potential. Recent years have been marked by the discovery of new compounds of marine origin and the study of their pharmacological activity. Marine organisms produce active compounds of various groups, including polysaccharides, polyphenols, pigments, sterols, vitamins, and others.

An effective and non-toxic anti-inflammatory agent is one of the key problems of modern science. Non-steroidal anti-inflammatory drugs and glucocorticoids are currently considered the most effective; however, a wide range of side effects affecting almost all organs and tissues of the body limit their long-term use. This special issue will focus on research papers, reviews, brief reports and prospects for the use of new marine compounds-based formulations with anti-inflammatory effects, in favor of new research, with clear and proven effects and industrial applications and focus.

Dr. Ekaterina D. Obluchinskaya
Dr. Olga N. Pozharitskaya
Guest Editors

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Keywords

  • allodynia
  • anti-inflammatory
  • cytokine storm
  • extraction
  • formulation
  • fractionation
  • hyperalgesia
  • interleukins
  • kinases
  • mechanisms of action
  • polysaccharides
  • polyphenols
  • sterols
  • lipids
  • pigment
  • prostaglandins
  • purification
  • synergy

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Published Papers (1 paper)

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Research

21 pages, 2958 KiB  
Article
Oral Macrocystis pyrifera Fucoidan Administration Exhibits Anti-Inflammatory and Antioxidant Properties and Improves DSS-Induced Colitis in C57BL/6J Mice
by Tauseef Ahmad, Muhammad Ishaq, Samuel Karpiniec, Ahyoung Park, Damien Stringer, Neeraj Singh, Vishal Ratanpaul, Karen Wolfswinkel, Helen Fitton, Vanni Caruso and Rajaraman Eri
Pharmaceutics 2022, 14(11), 2383; https://doi.org/10.3390/pharmaceutics14112383 - 4 Nov 2022
Cited by 11 | Viewed by 2494
Abstract
Inflammatory bowel disease (IBD) is a complex and multifactorial disorder characterised by relapsing and remitting inflammation of the intestinal tract. Oxidative stress (OS) is the result of an imbalance between production and accumulation of reactive oxygen species (ROS), which has been associated with [...] Read more.
Inflammatory bowel disease (IBD) is a complex and multifactorial disorder characterised by relapsing and remitting inflammation of the intestinal tract. Oxidative stress (OS) is the result of an imbalance between production and accumulation of reactive oxygen species (ROS), which has been associated with inflammatory responses and implicated in the exacerbation of IBD. Fucoidan, a sulfated polysaccharide from brown seaweed, is a well-known anti-inflammatory agent and emerging evidence indicates that fucoidan extracts from Macrocystis pyrifera (MPF and DP-MPF) may also modulate oxidative stress. This study investigated the impact of fucoidan extracts, MPF and DP-MPF in a dextran sodium sulphate (DSS)-induced mouse model of acute colitis. 3% DSS was administered in C57BL/6J male mice over a period of 7 days, and MPF and DP-MPF were co-administered orally at a dose of 400 mg/kg body weight. Our results indicated that MPF and DP-MPF significantly prevented body weight loss, improved the disease activity index (DAI), restored colon lengths, reduced the wet colon weight, reduced spleen enlargement, and improved the overall histopathological score. Consistent with the reported anti-inflammatory functions, fucoidan extracts, MPF and DP-MPF significantly reduced the colonic levels of myeloperoxidase (MPO), nitric oxide (NO), malondialdehyde (MDA) and increased the levels of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). In addition, MPF and DP-MPF significantly inhibited levels of pro-inflammatory cytokines in colon-derived tissues. Collectively, our results indicate that MPF and DP-MPF exhibited anti-inflammatory and antioxidant effects representing a promising therapeutic strategy for the cure of IBD. Full article
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