Novel Formulation Strategies for Enhancing Dissolution and/or Oral Bioavailability
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (15 January 2019) | Viewed by 88305
Special Issue Editors
Interests: dug delivery; pharmaceutics; oral delivery; controlled and sustained release; pharmaceutical technology
Special Issues, Collections and Topics in MDPI journals
Interests: drug delivery; micro/nanoparticles
Special Issues, Collections and Topics in MDPI journals
Interests: oral delivery; transdermal delivery; nasal delivery; delivery of biomacromolecules; nano drug delivery system; absorption mechanisms
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Poor oral bioavailability has become a major challenge in drug development due to both poor water-solubility and poor permeability across intestinal biomembranes. Despite significant efforts to optimize drug leads, about 40% of currently marketed drugs and 70% of drug candidates are poorly water-soluble. It is worse that a fraction of poorly water-soluble entities is poorly permeable as well. To enhance oral bioavailability, it is a prerequisite to improve the dissolution rate in the gastrointestinal tract. For BCS II (poor solubility, high permeability) drugs, enhancement of dissolution is workable, whereas for BCS IV (poor solubility, poor permeability), enhancement of both dissolution and permeability is highly demanded. Various formulation strategies have been employed in the past to enhance the dissolution and subsequent oral absorption of poorly water-soluble drugs, such as solid dispersion, inclusion complexation, nanosizing, co-crystallization and lipid-based delivery systems. Enhancing dissolution and/or oral bioavailability is an enduring theme.
This Special Issue serves as a forum to bring together prominent scientists from all around the world and presents their work together to draw attention from a grand audience. We invite review or original articles on all aspects of “Novel Formulation Strategies for Enhancing Dissolution and/or Oral Bioavailability”.
Prof. Wei Wu
Assoc. Prof. Yi Lu
Assoc. Prof. Jianping Qi
Guest Editors
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Keywords
- oral
- dissolution
- absorption
- bioavailability
- solid dispersion
- inclusion complex
- nanosuspension/nanocrystals
- co-crystals/co-amorphous systems
- porous and mesoporous materials
- lipid-based delivery systems
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