Special Issue "Depot Delivery Systems: Recent Advances on Materials, Technologies, and Beyond"
Deadline for manuscript submissions: closed (31 July 2020).
Interests: liposomes and lipid-based nanocarriers; depot injectables; targeted delivery; contrast agents for fluorescence functional imaging; cell-derived therapeutics and diagnostics
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By direct deposition of the drug at the site of action, depot delivery systems enable to limit the immediate exposure of the active principle at a systemic level and to reduce the frequency of administration. A reliable, steady, and prolonged drug release achieved with a non-invasive biocompatible system that can be conveniently produced and administered is an appealing solution to address various unmet clinical needs.
A large range of therapeutics, from small molecular drugs to larger biomacromolecules, can be loaded in in situ forming implants, microspheres, and injectable depots, to name a few, enabling to control the release from weeks till months. Despite the commercial success of a number of formulations, critical aspects such as the lack of correlation of in vitro with in vivo release profiles deriving from the inherent complexity of the physiological milieu, drug stability in the chosen matrix, burst release, low tolerability or foreign body reactions upon administration may affect dramatically product performance, jeopardizing a possible clinical success.
This Special Issue has the aim of highlighting current progress in the development of depot delivery systems with a particular attention to new technologies and new materials. Investigations on local tissue response to injections as well as studies on prototypes presenting a strong clinical potential will be also warmly welcomed.
Contributions could be submitted in the form of original research papers and review articles.
Prof. Dr. Paola Luciani
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- sustained release
- long acting injectables
- in situ forming implants
- controlled release injectables