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Pharmaceutics
Special Issues
Recent Advances in Cocrystal and Nano-Cocrystal Technologies for Pharmaceutical and...
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Recent Advances in Cocrystal and Nano-Cocrystal Technologies for Pharmaceutical and Nutraceutical Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 785

Special Issue Editor

Prof. Dr. Jiamei Chen

E-Mail Website
Guest Editor
School of Chemistry and Chemical Engineering, Tianjin University of Technology, Tianjin 300384, China
Interests: solid states of active ingredients (poly(a)morphs, hydrates, solvates, cocrystals, salts); nanocrystals and nano-cocrystals; solid-state characterization; crystal structure determination; X-ray diffraction; physicochemical characterization; in vitro/in vivo performance assessment

Special Issue Information

Dear Colleagues,

We are pleased to introduce our forthcoming Special Issue focused on “Recent Advances in Cocrystal and Nano-Cocrystal Technologies for Pharmaceutical and Nutraceutical Applications”. Cocrystal technology has long been recognized as an effective approach to modify the physicochemical properties of an active molecule without chemically modifying it. Nano-cocrystal formulation technology has recently emerged as a promising strategy to improve the solubility, dissolution rate, and potential bioavailability of poorly soluble active ingredients. Cocrystals and nano-cocrystals also allow for the co-delivery of two or more active ingredients through one dosage and further the development potential of combination products with pharmaceutical and nutraceutical applications.

In this Special Issue of Pharmaceutics, original research articles and reviews on the applications of cocrystal and nano-cocrystal technologies in the pharmaceutical and nutraceutical field are welcome. Research areas may include, but are not limited to, preparation methods, physicochemical characterization, and in vitro/in vivo performance assessment.

We look forward to receiving your contributions.

Prof. Dr. Jiamei Chen
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • crystal engineering
  • multicomponent crystals
  • cocrystal
  • nanococrystal
  • controllable synthesis
  • poorly soluble active ingredient
  • solubilization
  • bioavailability
  • pharmaceutical
  • nutraceutical
  • co-delivery
  • combination product

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Published Papers (1 paper)

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Research

19 pages, 5257 KiB  
Article
Development and Evaluation of Fluconazole Co-Crystal for Improved Solubility and Mechanical Properties
by Ritu Rathi, Inderbir Singh, Tanikan Sangnim and Kampanart Huanbutta
Pharmaceutics 2025, 17(3), 371; https://doi.org/10.3390/pharmaceutics17030371 - 14 Mar 2025
Viewed by 584
Abstract
Background: Fluconazole (FLZ) is a broad-spectrum anti-fungal drug presenting poor flowability, mechanical properties, and limited aqueous solubility. These issues pose challenges for the handling and manufacturing of dosage forms of FLZ. The current research aimed to develop fluconazole co-crystal (CC) for improving [...] Read more.
Background: Fluconazole (FLZ) is a broad-spectrum anti-fungal drug presenting poor flowability, mechanical properties, and limited aqueous solubility. These issues pose challenges for the handling and manufacturing of dosage forms of FLZ. The current research aimed to develop fluconazole co-crystal (CC) for improving its aqueous solubility, flowability, and mechanical properties. (2) Methods: The fluconazole benzoic acid (FLZ-BA) co-crystal was prepared using the solvent evaporation technique. The prepared co-crystal was characterized for drug content, solubility, anti-fungal activity, dissolution, and stability. DSC (Differential Scanning Calorimetry), PXRD (Powder X-Ray Diffraction), SEM (Scanning Electron Microscopy), and FTIR (Fourier Transmission Infrared) spectroscopy were carried out to confirm the co-crystal formation. The co-crystal was further evaluated for their flow characteristics and mechanical properties via CTC (compressibility, tabletability, and compactibility), Heckel, and Kawakita analysis. (3) Results: The CC showed 69.51% drug content and 13-fold greater aqueous solubility than pure FLZ. The DSC thermogram showed a sharp endothermic peak between the parent components, a distinct PXRD pattern was observed, and the SEM analysis revealed a different morphology, confirming the formation of co-crystal (new crystalline form). The CC showed immediate drug release and was found to more stable, and less hygroscopic than FLZ alone. The CC revealed better flowability, tabletability (tensile strength), compressibility, and compactibility. Moreover, Heckel and Kawakita analysis indicated the co-crystal to deform plastically, favoring improved compression. (4) Conclusions: The immediate drug release capabilities, improved hygroscopic stability, solubility, better antifungal activity, and flowability make FLZ-BA co-crystal a suitable candidate for the preparation of an immediate drug release dosage form. The study also revealed the application of co-crystal for improving the flowability and mechanical properties. Full article
(This article belongs to the Special Issue Recent Advances in Cocrystal and Nano-Cocrystal Technologies for Pharmaceutical and Nutraceutical Applications)
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