Special Issue "Design of Novel Polymeric Systems for Controlled Drug Delivery"

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 30 September 2021.

Special Issue Editor

Prof. Dr. Janusz Kasperczyk
E-Mail
Guest Editor
1) Medical University of Silesia, Faculty of Pharmaceutical Sciences, Poland
2) Polish Academy of Sciences, Centre of Polymer and Carbon Materials, Poland
Interests: polymeric drug delivery systems; influence of polymer chain structure for drug release; NMR spectroscopy for medical applications; polymer medical devices; resorbable implants containing drugs

Special Issue Information

Dear Colleagues,

Over the past decades, controlled drug delivery systems has become one of the most progressive scientific fields. The ability to control the structure of polymer chains in the process of polymer synthesis allows for the obtaining of polymeric drug carriers with strictly programmed physical and mechanical properties. The appropriate selection of such materials makes it possible to control the kinetics of drug release.

This Special Issue is dedicated to recent advances in the design and construction of DDS for the controlled release of pharmaceutically active substances using both biodegradable and stable polymer materials. It is dedicated to all types of drug forms for the construction of which polymers were used: micro and nanospheres, polymer micelles, targeted therapy systems, resorbable implants containing pharmaceutically active substances, coatings for stable implants releasing drugs including stents, implants in the form of microfibers or nano-nonwovens obtained by electrospinning including multidrug therapy, conjugates, nanotubes, polymerosomes, nanoparticles, etc. The discussion of the manufacturing of the advanced novel polymeric systems and their application in the pharmaceutical field is also welcome.

It is our pleasure to invite you to contribute a manuscript to this Special Issue. Full research papers, short communications, and reviews are all welcome.

The list of keywords below is not exhaustive, but it may help in preparing your submission. Please do not hesitate to go beyond it or to submit a paper whose topic is not explicitly mentioned in this list.

Best regards

Prof. Dr. Janusz Kasperczyk
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Drug delivery
  • Degradable polymers
  • Smart polymers
  • Controlled release
  • Pharmacokinetics
  • Structure–property relationship
  • NMR
  • Chain microstructure
  • Nonwovens
  • Self-assembly
  • Shape memory polymers
  • Electrospinning
  • Nanotubes
  • Conjugates
  • Polymerosomes
  • Microspheres
  • Micelles
  • Polymer nanoparticles
  • Thermoresponsive nanogels
  • Microcarrier
  • Drug delivery
  • Sensors
  • Stimuli responding hydrogels
  • Targeted therapy
  • Coatings
  • DDS

Published Papers (4 papers)

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Research

Open AccessArticle
Preparation of Electrospun Small Intestinal Submucosa/Poly(caprolactone-co-Lactide-co-glycolide) Nanofiber Sheet as a Potential Drug Carrier
Pharmaceutics 2021, 13(2), 253; https://doi.org/10.3390/pharmaceutics13020253 - 11 Feb 2021
Viewed by 422
Abstract
In this work, we chose small intestine submucosa (SIS) as a drug carrier because SIS possesses good biocompatibility, non-immunogenic property and bio-resorbability, and performed electrospinning for preparation of nanofiber sheets (NS). For the preparation of drug-loaded electrospun SIS nanofiber sheets as a drug [...] Read more.
In this work, we chose small intestine submucosa (SIS) as a drug carrier because SIS possesses good biocompatibility, non-immunogenic property and bio-resorbability, and performed electrospinning for preparation of nanofiber sheets (NS). For the preparation of drug-loaded electrospun SIS nanofiber sheets as a drug carrier, we used poly(ε-caprolactone-ran-l-lactide) (PCLA) copolymers to improve the electrospinning performance of SIS. The electrospinning of SIS and PCLA provided the electrospun SIS/PCLA (S/P)-nanofiber sheet (S/P-NS) with adjustable thickness and areas. The electrospun S/P-NS showed different porosities, pore sizes, diameters and tensile strengths depending on the ratios between SIS and PCLA. The electrospun S/P-NS was used as a drug carrier of the dexamethasone (Dex) and silver sulfadiazine (AgS) drug related to anti-inflammation. Dex-loaded S/P-NS and AgS-loaded S/P-NS was successfully fabricated by the electrospinning. In the in vitro and in vivo release, we successfully confirmed the possibility for the sustained release of Dex and AgS from the Dex-S/P-NS and AgS-S/P-NS for three weeks. In addition, the sustained Dex and AgS release suppressed the macrophage infiltration. Collectively, we achieved feasible development of SIS nanofiber sheets for a sustained Dex and AgS delivery system. Full article
(This article belongs to the Special Issue Design of Novel Polymeric Systems for Controlled Drug Delivery)
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Open AccessArticle
Structure-to-Efficacy Relationship of HPMA-Based Nanomedicines: The Tumor Spheroid Penetration Study
Pharmaceutics 2020, 12(12), 1242; https://doi.org/10.3390/pharmaceutics12121242 - 20 Dec 2020
Cited by 1 | Viewed by 560
Abstract
Nanomedicines are a novel class of therapeutics that benefit from the nano dimensions of the drug carrier. These nanosystems are highly advantageous mainly within cancer treatment due to their enhanced tumor accumulation. Monolayer tumor cells frequently used in routine preclinical assessment of nanotherapeutics [...] Read more.
Nanomedicines are a novel class of therapeutics that benefit from the nano dimensions of the drug carrier. These nanosystems are highly advantageous mainly within cancer treatment due to their enhanced tumor accumulation. Monolayer tumor cells frequently used in routine preclinical assessment of nanotherapeutics do not have a spatial structural architecture that allows the investigation of the penetration of nanomedicines to predict their behavior in real tumor tissue. Therefore, tumor spheroids from colon carcinoma C26 cells and glioblastoma U87-MG cells were used as 3D in vitro models to analyze the effect of the inner structure, hydrodynamic size, dispersity, and biodegradability of N-(2-hydroxypropyl)methacrylamide (HPMA) copolymer-based nanomedicines carrying anticancer drug pirarubicin (THP) on the penetration within spheroids. While almost identical penetration through spheroids of linear and star-like copolymers and also their conjugates with THP was observed, THP penetration after nanomedicines application was considerably deeper than for the free THP, thus proving the benefit of polymer carriers. The cytotoxicity of THP-polymer nanomedicines against tumor cell spheroids was almost identical as for the free THP, whereas the 2D cell cytotoxicity of these nanomedicines is usually lower. The nanomedicines thus proved the enhanced efficacy within the more realistic 3D tumor cell spheroid system. Full article
(This article belongs to the Special Issue Design of Novel Polymeric Systems for Controlled Drug Delivery)
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Open AccessArticle
Controlled Drug Release from Biodegradable Polymer Matrix Loaded in Microcontainers Using Hot Punching
Pharmaceutics 2020, 12(11), 1050; https://doi.org/10.3390/pharmaceutics12111050 - 03 Nov 2020
Cited by 2 | Viewed by 647
Abstract
Microcontainers are reservoir-based advanced drug delivery systems (DDS) that have proven to increase the bioavailibity of the small-molecule drugs, targeting of biomolecules, protection of vaccines and improved treatment of Pseudomonas aeruginosa. However, high-throughput loading of these micron-sized devices with drug has been challenging. [...] Read more.
Microcontainers are reservoir-based advanced drug delivery systems (DDS) that have proven to increase the bioavailibity of the small-molecule drugs, targeting of biomolecules, protection of vaccines and improved treatment of Pseudomonas aeruginosa. However, high-throughput loading of these micron-sized devices with drug has been challenging. Hot punching is a new technique that is a fast, simple and single-step process where the microdevices are themselves used as mold to punch biocompatible and biodegradable drug-polymer films, thereby loading the containers. Here, we investigate the effect of hot punching on the drug distribution as well as drug release from the loaded drug-polymer matrices. Zero-order sustained drug release is observed for the model drug Furosemide embedded in biodegradable polymer, Poly-ε-caprolactone, which is attributed to the unique spatial distribution of Furosemide during the loading process. Full article
(This article belongs to the Special Issue Design of Novel Polymeric Systems for Controlled Drug Delivery)
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Open AccessArticle
Biodegradable Electrospun Nonwovens Releasing Propolis as a Promising Dressing Material for Burn Wound Treatment
Pharmaceutics 2020, 12(9), 883; https://doi.org/10.3390/pharmaceutics12090883 - 17 Sep 2020
Cited by 3 | Viewed by 864
Abstract
The selection of dressing is crucial for the wound healing process. Traditional dressings protect against contamination and mechanical damage of an injured tissue. Alternatives for standard dressings are regenerating systems containing a polymer with an incorporated active compound. The aim of this research [...] Read more.
The selection of dressing is crucial for the wound healing process. Traditional dressings protect against contamination and mechanical damage of an injured tissue. Alternatives for standard dressings are regenerating systems containing a polymer with an incorporated active compound. The aim of this research was to obtain a biodegradable wound dressing releasing propolis in a controlled manner throughout the healing process. Dressings were obtained by electrospinning a poly(lactide-co-glycolide) copolymer (PLGA) and propolis solution. The experiment consisted of in vitro drug release studies and in vivo macroscopic treatment evaluation. In in vitro studies released active compounds, the morphology of nonwovens, chemical composition changes of polymeric material during degradation process, weight loss and water absorption were determined. For in vivo research, four domestic pigs, were used. The 21-day experiment consisted of observation of healing third-degree burn wounds supplied with PLGA 85/15 nonwovens without active compound, with 5 wt % and 10 wt % of propolis, and wounds rinsed with NaCl. The in vitro experiment showed that controlling the molar ratio of lactidyl to glycolidyl units in the PLGA copolymer gives the opportunity to change the release profile of propolis from the nonwoven. The in vivo research showed that PLGA nonwovens with propolis may be a promising dressing material in the treatment of severe burn wounds. Full article
(This article belongs to the Special Issue Design of Novel Polymeric Systems for Controlled Drug Delivery)
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