Advances in Physiologically-Based Pharmacokinetic Modeling
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 30 April 2026 | Viewed by 2
Special Issue Editors
Interests: clinical pharmacology; model-informed drug development; model-informed dose optimization; AI-driven drug development
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Physiologically-Based Pharmacokinetic (PBPK) modeling has become an indispensable tool in modern drug research and development. By combining physiological and biochemical information with drug-specific properties, PBPK models can predict pharmacokinetic behavior across different populations, disease conditions, and dosing regimens. Recent progress in computational methods, in vitro–in vivo extrapolation, and model verification has expanded the role of PBPK from early-stage drug discovery to regulatory submissions and individualized treatment strategies.
This Special Issue, Advances in Physiologically-Based Pharmacokinetic Modeling, seeks to highlight recent innovations, methodologies, and applications of PBPK modeling. We welcome original research articles and reviews covering diverse topics such as model qualification, drug–drug interactions, population-specific applications, integration with pharmacodynamics, and regulatory considerations. In particular, innovative studies exploring synergy with pharmacometrics, systems pharmacology, and artificial intelligence-driven methodologies to expand mechanistic and predictive insights are strongly encouraged. By gathering contributions from academia, industry, and regulatory agencies, this Special Issue aims to provide a comprehensive overview of current advances and future opportunities in PBPK modeling to support precision medicine.
Prof. Dr. Kwang-Hee Shin
Dr. Yun Kim
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- physiologically-based pharmacokinetic (PBPK) modeling
- population pharmacokinetics/pharmacodynamics (PopPK/PD)
- drug–drug interactions
- model-informed drug development (MIDD)
- quantitative systems pharmacology (QSP)
- regulatory science
- special populations
- artificial intelligence
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