Next-Generation Biomaterials for Oral Healthcare: Focus on Regenerative and Delivery Functions

Dear Colleagues,

Next-generation biomaterials are revolutionizing oral healthcare by combining regenerative capabilities with advanced drug delivery functions. These innovative materials offer non-invasive, patient-friendly, and cost-effective approaches for the treatment of both local and systemic diseases affecting the oral cavity and beyond. Recent advances in pharmaceutical and material sciences have led to the development of multifunctional oral biomaterials capable of targeted drug delivery, controlled release, enhanced bioavailability, and improved therapeutic outcomes, while simultaneously promoting tissue regeneration and repair.

A key focus of this Special Issue is the exploration of biomaterials with mucoadhesive, bioactive, and biocompatible properties, which prolong drug retention, optimize absorption at mucosal surfaces, and support the regeneration of oral tissues. This collection will highlight cutting-edge innovations in mucoadhesive systems, nanotechnology-based platforms, bioactive scaffolds, and smart delivery systems tailored for oral applications. Contributions will include preclinical and clinical research, as well as in vitro and ex vivo studies, providing valuable insights into the interaction between advanced biomaterials, drug formulations, and the unique biological environment of the oral cavity.

This Special Issue aims to address current challenges in overcoming physiological barriers, enhancing drug solubility and stability, and designing regenerative solutions for oral tissues. By bringing together interdisciplinary perspectives, this Special Issue offers a comprehensive overview of next-generation biomaterials for oral healthcare, fostering innovation and collaboration in the development of advanced therapeutics to meet the evolving needs of modern dentistry and oral medicine.

Dr. Giuseppina Nocca
Guest Editor

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