Oral Transmucosal Drug Delivery Systems for Local and Systemic Disease Treatment
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 31 December 2025 | Viewed by 1031
Special Issue Editor
2. Fondazione Policlinico Universitario A. Gemelli IRCCS, Roma, Italy
Interests: cell–material interactions; drug delivery; biological characterization of nano- and micromaterials
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Oral transmucosal drug delivery systems represent a cornerstone of modern pharmacology, offering non-invasive, patient-friendly, and cost-effective methods for the treatment of local and systemic diseases. Advances in pharmaceutical science have expanded the potential of oral transmucosal formulations, enabling targeted delivery, controlled release, enhanced bioavailability, and improved therapeutic efficacy. A key aspect here is the role of mucoadhesion, which prolongs drug retention and enhances absorption at mucosal surfaces, ultimately leading to improved therapeutic efficacy across various medical conditions.
This Special Issue explores the most advanced innovations in oral transmucosal drug delivery systems, including the development of mucoadhesive systems, novel excipients, nanotechnology platforms, and advanced drug-release mechanisms. The collection includes preclinical and clinical studies, as well as in vitro and ex vivo research, providing insights into the interaction between drug formulations and biological barriers. The topics address approaches to overcome physiological barriers, optimize drug solubility and stability, and assess performance through reliable in vitro and ex vivo models. This Issue brings together diverse perspectives to present a comprehensive overview of cutting-edge advancements in oral transmucosal drug delivery, fostering interdisciplinary collaboration and accelerating the development of innovative therapeutics to address the ever-changing needs of healthcare.
Dr. Giuseppina Nocca
Guest Editor
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Keywords
- transmucosal drug delivery
- transmucosal formulations
- excipients
- nanotechnology
- drug release
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