Research on the Development of Semi-solid Pharmaceutical Dosage Forms and Self-Emulsifying Drug Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 15 April 2026 | Viewed by 1937

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary
Interests: topical drug delivery; semi-solid pharmaceutical dosage forms; self-emulsifying drug delivery systems; nanocarriers; surfactants; in vitro studies; pharmaceutical technology; drug release; skin permeation
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmacy, University of Debrecen, Nagyerdei Körút 98, 4032 Debrecen, Hungary
Interests: topical drug delivery; self-emulsifying drug delivery systems; nanocarriers; surfactants; in vitro and in vivo studies; pharmaceutical technology; drug release; skin permeation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit a paper for the Special Issue “Research on the Development of Semi-solid Pharmaceutical Dosage Forms and Self-Emulsifying Drug Delivery Systems”. Semi-solid dosage forms offer ease of application, controlled release of active ingredients, and improved patient compliance. The incorporation of self-emulsifying drug delivery systems into semi-solid pharmaceutical dosage forms provides a promising strategy for overcoming the challenges associated with poor drug solubility, bioavailability, and patient compliance.

This Special Issue aims to highlight the current progress in the development of innovative semi-solid dosage forms and self-emulsifying drug delivery systems, regardless of their therapeutic target.

We welcome researchers to contribute original research and review articles focusing on the formulation and investigation of novel semi-solid pharmaceutical dosage forms, including creams, ointments, gels, and transdermal patches, as well as self-emulsifying drug delivery systems.

We look forward to receiving your contributions.

Dr. Pálma Fehér
Dr. Liza Józsa
Guest Editors

Manuscript Submission Information

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Keywords

  • semi-solid dosage forms
  • ointments
  • creams
  • gels
  • transdermal patches
  • self-emulsifying drug delivery systems
  • topical delivery
  • transdermal delivery

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Published Papers (1 paper)

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Research

25 pages, 2673 KiB  
Article
Development of Salvia officinalis–Based Self-Emulsifying Systems for Dermal Application: Antioxidant, Anti-Inflammatory, and Skin Penetration Enhancement
by Krisztina Bodnár, Boglárka Papp, Dávid Sinka, Pálma Fehér, Zoltán Ujhelyi, István Lekli, Richárd Kajtár, Fruzsina Nacsa, Ildikó Bácskay and Liza Józsa
Pharmaceutics 2025, 17(2), 140; https://doi.org/10.3390/pharmaceutics17020140 - 21 Jan 2025
Viewed by 1353
Abstract
Background/Objectives: The present study focused on the formulation and evaluation of novel topical systems containing Salvia officinalis (sage), emphasizing their antioxidant and anti-inflammatory properties. Sage, rich in carnosol, offers considerable therapeutic potential, yet its low water solubility limits its effectiveness in traditional formulations. [...] Read more.
Background/Objectives: The present study focused on the formulation and evaluation of novel topical systems containing Salvia officinalis (sage), emphasizing their antioxidant and anti-inflammatory properties. Sage, rich in carnosol, offers considerable therapeutic potential, yet its low water solubility limits its effectiveness in traditional formulations. The aim of our experimental work was to improve the solubility and thus bioavailability of the active ingredient by developing self-nano/microemulsifying drug delivery systems (SN/MEDDSs) with the help of Labrasol and Labrafil M as the nonionic surfactants, Transcutol HP as the co-surfactant, and isopropyl myristate as the oily phase. Methods: The formulations were characterized for droplet size, zeta potential, polydispersity index (PDI), encapsulation efficacy, and stability. The composition exhibiting the most favorable characteristics, with particle sizes falling within the nanoscale range, was incorporated into a cream and a gel, which were compared for their textural properties, carnosol penetration, biocompatibility and efficacy. Results: Release studies conducted using Franz diffusion cells demonstrated that the SNEDDS-based cream achieved up to 80% carnosol release, outperforming gels. The 2,2-diphenyl-1-picrylhydrazyl (DPPH) test and enzyme-linked immunosorbent assays (ELISA) showed strong efficacy, with an in vivo carrageenan-induced rat paw edema model revealing that the SNEDDS-based cream significantly reduced inflammation. Conclusions: These findings highlight the potential of SNEDDS-enhanced topical formulations in improving therapeutic outcomes. Further research is warranted to confirm their long-term safety and efficacy. Full article
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