Model Informed Precision Dosing in Special Populations: Bridging Physiology, Models and Clinical Practice
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".
Deadline for manuscript submissions: 28 February 2026 | Viewed by 32
Special Issue Editor
Interests: PBPK; pregnancy; neonate; pharmacy
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Pharmacokinetic modeling in special populations is essential to achieve precision dosing where standard clinical trials are limited or unfeasible. This Special Issue focuses on the development and application of physiologically based pharmacokinetic (PBPK) and population PK (PopPK) models to optimize drug dosing in pregnancy, neonates, pediatrics, the elderly, and patients with organ impairment or obesity. These populations present unique physiological challenges—such as altered metabolism, maturation-dependent clearance, placental transfer, and age-related decline in renal/hepatic function—that significantly impact drug disposition. PBPK models enable mechanistic simulations of system changes over time, while PopPK identifies covariate influences on variability and informs real-world dosing strategies. We invite submissions that present new models, model qualification against clinical data, virtual clinical trial simulations, and case studies demonstrating clinical translation or regulatory engagement. The aim of this Special Issue is to advance model-informed approaches to improve drug safety, efficacy, and personalized therapy in vulnerable and underrepresented patient groups.
Dr. Raj Badhan
Guest Editor
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Keywords
- PBPK
- PopPK
- pregnancy
- neonates
- pediatrics
- geriatrics
- dosing
- pharmacokinetics
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