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Pharmaceutics
Special Issues
Nanotechnology in the Treatment of Neglected Parasitic Diseases
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Nanotechnology in the Treatment of Neglected Parasitic Diseases

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 31 August 2025 | Viewed by 142

Special Issue Editors

Prof. Dr. Eduardo Ricci Junior

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Guest Editor
Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21941-902, RJ, Brazil
Interests: nanotechnology; microtechnology; neglected diseases; modified release; nanoparticles; nanoemulsions; liposomes
Special Issues, Collections and Topics in MDPI journals
Dr. Ana Paula dos Santos Matos

E-Mail Website
Guest Editor
1. Laboratório de Farmacotécnica Experimental (LabFE), Instituto de Tecnologia em Fármacos-Farmanguinhos, Fundação Oswaldo Cruz—Fiocruz, Rio de Janeiro, RJ, Brazil
2. Departamento de Fármacos e Medicamentos, Faculdade de Farmácia, Universidade Federal do Rio de Janeiro (UFRJ), Cidade Universitária, Ilha do Fundão, Rio de Janeiro 21941-902, RJ, Brazil
Interests: nanotechnology; microtechnology; neglected diseases; modified release; nanoparticles; nanoemulsions; polymers; 3D printing

Special Issue Information

Dear Colleagues,

We are pleased to announce a Special Issue of Pharmaceutics entitled "Nanotechnology in the Treatment of Neglected Parasitic Diseases". This Special Issue will discuss advances in treating neglected parasitic diseases involving nanotechnology. We welcome articles that address nanosystems such as nanoparticles, liposomes, nanoemulsions, and polymeric micelles. Review articles that outline the evolution of nanosystems in this area and articles that address modified drug delivery systems in the treatment of neglected diseases will also be considered. If you have recently completed work in this area, please submit your article for this Special Issue. If you have any questions, please do not hesitate to contact us; we are happy to help.

Prof. Dr. Eduardo Ricci Junior
Dr. Ana Paula dos Santos Matos
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • neglected disease
  • nanotechnology
  • parasitic disease
  • modified release
  • sustained release
  • nanoparticles
  • liposomes
  • nanoemulsions

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Published Papers (1 paper)

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Research

23 pages, 6606 KiB  
Article
Clove Oil-Based Nanoemulsion Containing Amphotericin B as a Therapeutic Approach to Combat Fungal Infections
by Marcel Lucas de Almeida, Ana Paula dos Santos Matos, Veronica da Silva Cardoso, Tatielle do Nascimento, Ralph Santos-Oliveira, Leandro Machado Rocha, Francisco Paiva Machado, Franklin Chimaobi Kenechukwu, Alane Beatriz Vermelho and Eduardo Ricci-Júnior
Pharmaceutics 2025, 17(7), 925; https://doi.org/10.3390/pharmaceutics17070925 - 17 Jul 2025
Abstract
Background/Objectives: Candidiasis, primarily caused by Candida albicans, and sporotrichosis, mainly caused by Sporothrix schenckii, are skin fungal infections that pose serious threats to global health. The Candida auris is a great concern in immunocompromised individuals, and while Sporothrix brasiliensis cause sporotrichosis, [...] Read more.
Background/Objectives: Candidiasis, primarily caused by Candida albicans, and sporotrichosis, mainly caused by Sporothrix schenckii, are skin fungal infections that pose serious threats to global health. The Candida auris is a great concern in immunocompromised individuals, and while Sporothrix brasiliensis cause sporotrichosis, an infection commonly found in cats, this disease can be transmitted to humans through scratches or bites. Existing treatments for these fungal infections often cause problems related to resistance and significant side effects. Consequently, development of alternative therapeutic approaches such as nanotechnology-based topical lipid-based formulations is interesting. Thus, the objectives of this study were to prepare clove oil (CO)-in-water nanoemulsions (NEs) containing amphotericin B (AmB) and characterize them with respect to stability, release profile, and in vitro cytotoxic activity against Candida and Sporothrix strains. As a future alternative for the treatment of fungal skin diseases. Methods: Chemical analysis of clove oil was obtained by GC-MS. The NEs were produced using an ultrasound (sonicator) method with varying proportions of CO, Pluronic® F-127, and AmB. The NEs were characterized by droplet size, morphology, stability and in vitro release profile. The antifungal and cytotoxic activity against C. albicans, C. auris, S. schenckii, and S. brasiliensis were ascertained employing agar diffusion and colorimetric MTT assay methods. A checkerboard assay was carried out using clove oil and amphotericin B against C. auris. Results: Eugenol was the major compound identified in CO at a concentration of 80.09%. AmB-loaded NEs exhibited particle sizes smaller than 50 nm and a polydispersity index below 0.25. The optimal Ne (NEMLB-05) remained stable after 150 days of storage at 4 °C. It exhibited rapid release within the first 24 h, followed by a slow and controlled release up to 96 h. NEMLB-05 more effectively inhibited C. auris compared to free AmB and also demonstrated greater activity against C. albicans, S. schenckii, and S. brasiliensis. Clove oil and amphotericin B presented synergism inhibiting the growth of C. auris. Conclusions: The selected CO-in-water NEs containing AmB demonstrated promising potential as a topical therapeutic alternative for treating fungal infections. Full article
(This article belongs to the Special Issue Nanotechnology in the Treatment of Neglected Parasitic Diseases)
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