Bio-Nanoparticle Systems for Brain Drug Delivery

Dear Colleagues,

This Special Issue explores the development and application of bio-nanoparticle systems for brain drug delivery, addressing critical challenges such as the blood–brain barrier and the need for targeted therapies. Bio-nanoparticles, including lipid-based and polymeric nanoparticles, as well as biomimetic systems like exosomes, offer innovative solutions for the treatment of neurological disorders, including neurodegenerative diseases, brain tumors, and CNS-related conditions. Research on functionalization strategies with which to enhance brain targeting, improve cellular uptake, and achieve precise drug release is highly encouraged. Contributions focusing on biocompatibility, safety, and the therapeutic potential of bio-nanoparticles in the delivery of small molecules, RNA, DNA, and proteins are particularly welcome. This Special Issue seeks to highlight cutting-edge advances in nanotechnology, promoting interdisciplinary approaches that combine nanomedicine, biology, and neuroscience to overcome current limitations in brain drug delivery systems.

I invite researchers to contribute with original research articles as well as review articles, which will increase the knowledge and new perspectives concerning new strategies for the development and application of new bio-nanoparticle systems for brain drug delivery, new biological targets, and pharmacological effects.

Dr. Valentina Pagliara
Dr. Raffaella D'Auria
Guest Editors

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