Design of Novel Polymeric Systems for Controlled Drug Delivery, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 July 2024 | Viewed by 3560

Special Issue Editors


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Guest Editor
1. Faculty of Pharmaceutical Sciences, Medical University of Silesia, Katowice, Poland
2. Centre of Polymer and Carbon Materials, Polish Academy of Sciences, Zabrze, Poland
Interests: polymeric drug delivery systems; influence of polymer chain structure for drug release; NMR spectroscopy for medical applications; polymer medical devices; resorbable implants containing drugs
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Guest Editor
Center of Polymer and Carbon Materials of the Polish Academy of Sciences, Zabrze, Poland
Interests: drug delivery; polymeric micelles; paclitaxel; filomicelles; PLA/PEG

Special Issue Information

Dear Colleagues,

Over the past decades, controlled drug delivery systems have become one of the most progressive scientific fields. The ability to control the structure of polymer chains in the process of polymer synthesis allows for the obtaining of polymeric drug carriers with strictly programmed physical and mechanical properties. The appropriate selection of such materials makes it possible to control the kinetics of drug release.

This Special Issue is dedicated to recent advances in the design and construction of DDS for the controlled release of pharmaceutically active substances using both biodegradable and stable polymer materials. It is dedicated to all types of drug forms for the construction of which polymers were used: micro and nanospheres, polymer micelles, targeted therapy systems, resorbable implants containing pharmaceutically active substances, coatings for stable implants releasing drugs including stents, implants in the form of microfibers or nano-nonwovens obtained by electrospinning including multidrug therapy, conjugates, nanotubes, polymerosomes, nanoparticles, etc. The discussion of the manufacturing of advanced novel polymeric systems and their application in the pharmaceutical field are also welcome.

It is our pleasure to invite you to contribute a manuscript to this Special Issue. Full research papers, short communications, and reviews are all welcome.

The list of keywords below is not exhaustive, but it may help in preparing your submission. Please do not hesitate to go beyond it or to submit a paper whose topic is not explicitly mentioned in this list.

Prof. Dr. Janusz Kasperczyk
Dr. Katarzyna Jelonek
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

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Keywords

  • drug delivery
  • degradable polymers
  • smart polymers
  • controlled release
  • pharmacokinetics
  • structure–property relationship
  • NMR
  • chain microstructure
  • nonwovens
  • self-assembly
  • shape memory polymers
  • electrospinning
  • nanotubes
  • conjugates
  • polymerosomes
  • microspheres
  • micelles
  • polymer nanoparticles
  • thermoresponsive nanogels
  • microcarrier
  • drug delivery
  • sensors
  • stimuli responding hydrogels
  • targeted therapy
  • coatings
  • DDS

Published Papers (3 papers)

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Research

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14 pages, 2494 KiB  
Article
Physical Ageing of Amorphous Poly(lactic acid)-Indapamide System Studied by Differential Scanning Calorimetry
by Marcin Skotnicki, Agata Drogoń, Janina Lulek and Marek Pyda
Pharmaceutics 2023, 15(9), 2341; https://doi.org/10.3390/pharmaceutics15092341 - 19 Sep 2023
Viewed by 613
Abstract
The process of isothermal and non-isothermal physical ageing of amorphous polylactide (PLA) with the active pharmaceutical ingredient, indapamide (IND), was investigated. A PLA–IND system with a 50/50 weight ratio was obtained and characterized using differential scanning calorimetry (DSC). In the 50/50 (w [...] Read more.
The process of isothermal and non-isothermal physical ageing of amorphous polylactide (PLA) with the active pharmaceutical ingredient, indapamide (IND), was investigated. A PLA–IND system with a 50/50 weight ratio was obtained and characterized using differential scanning calorimetry (DSC). In the 50/50 (w/w) mixture, two glass transitions were observed: the first at 64.1 ± 0.3 °C corresponding to the glass transition temperature (Tg) of PLA, and the second at 102.6 ± 1.1 °C corresponding to the Tg of IND, indicating a lack of molecular mixing between the two ingredients. The PLA–IND system was subjected to the isothermal physical ageing process at different ageing temperatures (Ta) for 2 h. It was observed that the highest effect of physical ageing (enthalpy relaxation change) on IND in the PLA–IND system occurred at Ta = 85 °C. Furthermore, the system was annealed for various ageing times at 85 °C. The relaxation enthalpies were estimated for each experiment and fitted to the Kohlrausch–Williams–Watts (KWW) equation. The KWW equation allowed for the estimation of the relaxation time and the parameter describing the distribution of relaxation times of the isothermal physical ageing process of IND in the PLA–IND system. The physical ageing of the PLA–IND mixture (50/50) was also discussed in the context of heat capacity. Moreover, the activation energy and fragility parameters were determined for the PLA–IND (50/50) system. Full article
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Review

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21 pages, 4411 KiB  
Review
Polysaccharides as a Hydrophilic Building Block of Amphiphilic Block Copolymers for the Conception of Nanocarriers
by Aijing Lu and Suming Li
Pharmaceutics 2024, 16(4), 467; https://doi.org/10.3390/pharmaceutics16040467 - 27 Mar 2024
Viewed by 531
Abstract
Polysaccharides are gaining increasing attention for their relevance in the production of sustainable materials. In the domain of biomaterials, polysaccharides play an important role as hydrophilic components in the design of amphiphilic block copolymers for the development of drug delivery systems, in particular [...] Read more.
Polysaccharides are gaining increasing attention for their relevance in the production of sustainable materials. In the domain of biomaterials, polysaccharides play an important role as hydrophilic components in the design of amphiphilic block copolymers for the development of drug delivery systems, in particular nanocarriers due to their outstanding biocompatibility, biodegradability, and structural versatility. The presence of a reducing end in polysaccharide chains allows for the synthesis of polysaccharide-based block copolymers. Compared with polysaccharide-based graft copolymers, the structure of block copolymers can be more precisely controlled. In this review, the synthesis methods of polysaccharide-based amphiphilic block copolymers are discussed in detail, taking into consideration the structural characteristics of polysaccharides. Various synthetic approaches, including reductive amination, oxime ligation, and other chain-end modification reactions, are explored. This review also focuses on the advantages of polysaccharides as hydrophilic blocks in polymeric nanocarriers. The structure and unique properties of different polysaccharides such as cellulose, hyaluronic acid, chitosan, alginate, and dextran are described along with examples of their applications as hydrophilic segments in the synthesis of amphiphilic copolymers to construct nanocarriers for sustained drug delivery. Full article
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19 pages, 1675 KiB  
Review
Non-spherical Polymeric Nanocarriers for Therapeutics: The Effect of Shape on Biological Systems and Drug Delivery Properties
by Prescillia Lagarrigue, Filippo Moncalvo and Francesco Cellesi
Pharmaceutics 2023, 15(1), 32; https://doi.org/10.3390/pharmaceutics15010032 - 22 Dec 2022
Cited by 8 | Viewed by 1771
Abstract
This review aims to highlight the importance of particle shape in the design of polymeric nanocarriers for drug delivery systems, along with their size, surface chemistry, density, and rigidity. Current manufacturing methods used to obtain non-spherical polymeric nanocarriers such as filomicelles or nanoworms, [...] Read more.
This review aims to highlight the importance of particle shape in the design of polymeric nanocarriers for drug delivery systems, along with their size, surface chemistry, density, and rigidity. Current manufacturing methods used to obtain non-spherical polymeric nanocarriers such as filomicelles or nanoworms, nanorods and nanodisks, are firstly described. Then, their interactions with biological barriers are presented, including how shape affects nanoparticle clearance, their biodistribution and targeting. Finally, their drug delivery properties and their therapeutic efficacy, both in vitro and in vivo, are discussed and compared with the characteristics of their spherical counterparts. Full article
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