Manipulation of the Blood–Brain Barrier
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".
Deadline for manuscript submissions: 30 November 2025
Special Issue Editors
2. Department of Surgery, Division of Neurosurgery and Neuro-Oncology, Centre Intégré Universitaire de Santé et de Services Sociaux de l’Estrie—Centre Hospitalier Universitaire de Sherbrooke, 3001 12e Avenue Nord, Sherbrooke, QC J1H 5H3, Canada
Interests: blood–brain barrier (BBB); BBB manipulation; brain tumors; intra-arterial chemotherapy; CNS delivery; glioma models; liposomes; neuro-oncology
Special Issues, Collections and Topics in MDPI journals
Interests: intra-arterial chemotherapy; glioma treatment; CNS delivery; gliomas and glioblastomas
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Since its inception, the field of blood–brain barrier manipulations, to selectively increase therapeutic agents’ brain concentration to treat central nervous system (CNS) disease, has seen many changes and advancements, and so has its recognition in terms of its clinical relevance. Initially considered a fringe discipline, it is nowadays unavoidable when discussing the treatment of CNS diseases. In 1908, the German physician Paul Ehrlich stipulated, “To exert its effect, a molecule must first reach its target.”; hence, highlighting the relevance of circumventing the BBB for therapeutic purposes.
This Special Issue is dedicated to addressing this delivery impediment in treating brain diseases via different strategies that all share the same goal. We are pleased to invite you to submit original research articles and reviews that thoroughly describe the physiological and pharmacological aspects of the BBB, various detailed approaches for CNS delivery, and those discussing specific shortcomings and advantages. We aim to gather a collection of articles that identify delivery strategies, which are either actively in use or about to be clinically used. Our Special Issue also intends to publish papers describing what the future might hold in the field of delivery across the BBB. Research areas may include (but are not limited to) the following: BBB physiology and pathological remodeling, intra-arterial chemotherapy, BBB disruption, convection-enhanced delivery, and nanocarriers.
We look forward to your submissions.
Prof. Dr. David Fortin
Dr. Laurent-Olivier Roy
Guest Editors
Manuscript Submission Information
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Keywords
- blood–brain barrier (BBB)
- intra-arterial infusion
- BBB manipulation
- efflux transporters
- CNS delivery
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