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Pharmaceuticals publishes Special Issues to create collections of papers on specific topics, with the aim of building a community of authors and readers to discuss the latest research and develop new ideas and research directions. Special Issues are led by Guest Editors, who are experts on the topic and all Special Issue submissions follow MDPI's standard editorial process. The journal’s Editor-in-Chief and/or designated Editorial Board Member will oversee Guest Editor appointments and Special Issue proposals, checking their content for relevance and ensuring the suitability of the material for the journal. The papers published in a Special Issue will be collected and displayed on a dedicated page of the journal’s website. Further information on MDPI's Special Issue policies and Guest Editor responsibilities can be found here. For any inquiries related to a Special Issue, please contact the Editorial Office.

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Exploring Natural Products with Antioxidant and Anticancer Properties, 2nd Edition

edited by

Sikiru Olaitan Balogun

and

Edson Lucas Dos Santos

submission deadline 25 Mar 2026 | 1 articles | Viewed by 186 | Submission Open

Keywords: antioxidant; anticancer; neoplasms; natural products; cytotoxicity

(This special issue belongs to the Section Natural Products)

Metal-Based Nanoparticles’ Biological Activity and Pharmaceutical Applications, 2nd Edition

edited by

Elitsa L. Pavlova

and

Debbie C. Crans

submission deadline 25 Mar 2026 | Viewed by 159 | Submission Open

Keywords: metal nanoparticles; redox reactions; biological activity; pharmaceuticals; cytotoxicity; antibacterial effect; oxidative stress; disease; safety; in vivo applications

(This special issue belongs to the Section Medicinal Chemistry)

Novel Anti-Obesity Pharmacotherapies

edited by

Khanyisani Ziqubu

and

Zibele Ndlovu

submission deadline 25 Mar 2026 | Viewed by 150 | Submission Open

Keywords: obesity; anti-obesity pharmacotherapy; weight management; combination therapy; incretin-based polyagonists; amylin analogs; melanocortin receptor modulators; fibroblast growth factor mimetics; mitochondrial uncoupler; clinical efficacy; obesity-induced diseases

(This special issue belongs to the Section Pharmacology)

Crystal Engineering in the Pharmaceutical Sciences

edited by

Stephen Robert Byrn

submission deadline 25 Mar 2026 | Viewed by 129 | Submission Open

Keywords: intermolecular interactions; cocrystals; salts; disproportionation; crystal structure prediction; space manufacturing

(This special issue belongs to the Section Medicinal Chemistry)

Novel Vasoactive and Anti-Inflammatory Agents: From Mechanisms to Therapeutic Applications

edited by

Thyago Moreira De Queiroz

and Alice Valença Araújo

submission deadline 25 Mar 2026 | Viewed by 100 | Submission Open

Keywords: vasorelaxation; inflammation; oxidative stress; nitric oxide; natural and synthetic products; blood pressure

(This special issue belongs to the Section Pharmacology)

Kynurenine Pathway: A Novel Therapeutic Opportunity—2nd Edition

edited by

Verónica Pérez de la Cruz

Tonali Blanco-Ayala

and

Daniela Ramírez-Ortega

submission deadline 25 Mar 2026 | Viewed by 90 | Submission Open

Keywords: tryptophan catabolism; redox modulation; kynurenines; immunoregulation

(This special issue belongs to the Section Pharmacology)

Pharmacotherapy and Molecular Biomarkers of Metabolic Diseases

edited by Kathleen F. Saavedra Peña and

Nicolás R. Saavedra Cuevas

submission deadline 25 Mar 2026 | Viewed by 87 | Submission Open

Keywords: molecular biomarkers; cardiovascular diseases; metabolic diseases; precision medicine; pharmacogenomics; translational research; omics technologies; drug response variability; personalized medicine

(This special issue belongs to the Section Pharmacology)

Advancements in Cardiovascular and Antidiabetic Drug Therapy, 2nd Edition

edited by

Alfredo Caturano

submission deadline 27 Mar 2026 | 14 articles | Viewed by 17946 | Submission Open

Keywords: cardiovascular diseases; antidiabetic drugs; pharmacological interventions; sodium– glucose cotransporter 2 inhibitors; PCSK9 inhibitors; obeticholic acid; lipid-lowering agents; heart failure treatment; diabetes management; drug therapy innovations

(This special issue belongs to the Section Pharmacology)

Therapeutic Applications of Micro-RNA in Cancer Management

edited by

Alma D. Campos-Parra

submission deadline 27 Mar 2026 | 2 articles | Viewed by 2876 | Submission Open

Keywords: cancer; miRNAs; therapeutic applications; miRNA treatments

(This special issue belongs to the Section Biopharmaceuticals)

Structural Insights into Protein Kinases-Targeted Therapies: Overcoming Resistance and Advancing Precision Oncology

edited by David Hecht

submission deadline 27 Mar 2026 | 2 articles | Viewed by 986 | Submission Open

Keywords: protein kinases inhibitor resistance; structural biology of of protein kinases; computational modeling; drug design; preclinical and clinical studies; precision oncology; ALK resistance for personalized medicine

(This special issue belongs to the Section Medicinal Chemistry)

Innovative Drug Delivery Systems for Enhanced Dissolution and Bioavailability

edited by Marival Bermejo,

Paloma Marina De la Torre-Iglesias

and Covadonga Álvarez-Álvarez

submission deadline 27 Mar 2026 | Viewed by 317 | Submission Open

Keywords: drug dissolution enhancement; oral bioavailability improvement; poorly soluble drugs; solid dispersions; nanoparticle drug delivery; amorphous formulations; 3D printing in pharmaceuticals; advanced drug-polymer systems; advanced excipients for solubility enhancement; controlled drug release

(This special issue belongs to the Section Pharmaceutical Technology)

Discovery and Validation of Novel Antimicrobial Molecules for the Treatment of Multidrug-Resistant Bacterial Infections

edited by

Paolo Gaibani

and Rocco Latorre

submission deadline 27 Mar 2026 | Viewed by 315 | Submission Open

Keywords: antibiotics therapy; multidrug resistance; bacterial infection

(This special issue belongs to the Section Pharmacology)

Identification and Extraction of Bioactive Compounds from Marine Life

edited by

Monde Mc Millan Ntwasa

and Wilfred T. Mabusela

submission deadline 27 Mar 2026 | Viewed by 248 | Submission Open

Keywords: natural products; marine life; bioactive compounds; cancer; antimicrobials

(This special issue belongs to the Section Natural Products)

Molecular Systems for the Delivery of Drugs and Contrast Agents, 2nd Edition

edited by

Angelo Maspero

Luca Nardo

and

Marco Lamperti

submission deadline 27 Mar 2026 | Viewed by 75 | Submission Open

Keywords: biomarker-targeted drugs; contrast media for diagnostic imaging; drug delivery systems; photoactivated drugs and photoswitches; theranostics; liposomes; biomaterials-based drugs and drug shuttles (e.g.; DNA origami); biomimetic materials; nanoparticle applications to diagnostics and therapy; in silico drug design

(This special issue belongs to the Section Medicinal Chemistry)

Exploring the Anticancer and Immunomodulatory Mechanisms of Phytochemicals and Natural Bioactive Compounds

edited by Suyun Lyu

submission deadline 31 Mar 2026 | 8 articles | Viewed by 17220 | Submission Open

Keywords: natural products; phytochemicals; anticancer; immunomodulation; bioactive compounds

(This special issue belongs to the Section Pharmacology)

A Commemorative Special Issue in Honor of Professor Eliezer J. Barreiro: Early Drug Discovery: From Target Identification and Validation to Lead Optimization

edited by

Luzineide Tinoco

and

Lídia Lima

submission deadline 31 Mar 2026 | 3 articles | Viewed by 5564 | Submission Open

Keywords: target validation; LBDD; FBDD; SBDD; QSAR; artificial intelligence; organic synthesis; natural product; drug discovery; medicinal chemistry

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Antiparasitic Drug Research

edited by

Andre Aires

and

Maria Cristiano

submission deadline 31 Mar 2026 | 3 articles | Viewed by 3178 | Submission Open

Keywords: antiparasitic drug; novel drug targets; parasite resistance; drug efficacy; parasite genetics

(This special issue belongs to the Section Pharmacology)

Recent Advances in Natural Product-Based Nanostructured Systems: 2nd Edition

edited by

Luís Alexandre Muehlmann

and

João Paulo Longo

submission deadline 31 Mar 2026 | 1 articles | Viewed by 2524 | Submission Open

Keywords: natural product; nanostructured systems; nanotechnology; nanostructures; nanocarriers; bioactive compounds

(This special issue belongs to the Section Natural Products)

Natural Product-Derived Treatments of Neurological and Neuropsychiatric Disorders

edited by

Cristiane S. F. Maia

Enéas A. Fontes-Júnior

Mozaniel Santana de Oliveira

and Jofre J. S. Freitas

submission deadline 31 Mar 2026 | 3 articles | Viewed by 1081 | Submission Open

Keywords: natural products; bioactive compounds; neurological conditions; psychiatric disorders; phytomedicine

Peptide-Based Drug Discovery: Innovations and Breakthroughs

edited by

Santo Previti

submission deadline 31 Mar 2026 | 1 articles | Viewed by 962 | Submission Open

Keywords: drug discovery; peptide-based compounds; peptidomimetics; target modulation; structure– activity relationship studies; hit molecules; AI-driven drug discovery; ligand-based drug design; structure-based drug design; computer-aided drug design

(This special issue belongs to the Section Medicinal Chemistry)

Bioactive Compounds from Plants and Foods: From Traditional Medicine to Modern Applications in Nutrition and Health

edited by

Sendar Nery-Flores

Filiberto Gutierrez-Gutierrez

, Walter Trujillo-Rangel and

Raúl Rodríguez-Herrera

submission deadline 31 Mar 2026 | 1 articles | Viewed by 645 | Submission Open

Keywords: herbal extracts; natural compounds; nutraceuticals; bioactive compounds; in vitro and in vivo studies; biological activities; phytochemistry; natural product drug discovery; computational screening of natural products; nanomaterials for natural product extraction

(This special issue belongs to the Section Natural Products)

Synthesis and Biological Activity of Metal Complexes

edited by

Francois Dufrasne

submission deadline 31 Mar 2026 | Viewed by 352 | Submission Open

Keywords: metal complexes; biological activity; synthesis; pharmacology; cancer; pathogens; medicine; chemistry; stability; target

(This special issue belongs to the Section Medicinal Chemistry)

Advances in Small-Molecule Therapeutics Targeting Signaling Pathways

edited by

Arianna Gelain

submission deadline 31 Mar 2026 | Viewed by 209 | Submission Open

Keywords: small molecules; natural compounds; synthetic compounds; signaling pathways; drug design; drug development; HTS; computational tools; biological evaluations; QSAR; bioavailability; pharmacokinetics

(This special issue belongs to the Section Medicinal Chemistry)

Stem Cells in Oncology: Emerging Targets for Therapy

edited by

Ling Li

and

Umesh P Yadav

submission deadline 31 Mar 2026 | Viewed by 169 | Submission Open

Keywords: cancer stem cells (CSCs); tumor microenvironment (TME); targeted therapy; treatment resistance; biomarkers

(This special issue belongs to the Section Biopharmaceuticals)

Antimicrobial and Anticancer Scaffolds in Medicinal Chemistry

edited by

Monika Pitucha

submission deadline 31 Mar 2026 | 1 articles | Viewed by 98 | Submission Open

Keywords: antimicrobial; anticancer; synthesis; complex; organic compounds; heterocyclic compounds; SAR

(This special issue belongs to the Section Medicinal Chemistry)

Design, Synthesis and Pharmacological Evaluation of Novel Opioid/Non-Opioid Hybrid Compounds

edited by Justyna Piekielna-Ciesielska and

Katarzyna Gach-Janczak

submission deadline 31 Mar 2026 | Viewed by 86 | Submission Open

Keywords: opioid; opioid hybrids; pain; opioid-related side-effects; tolerance; addiction; neurotransmitters

(This special issue belongs to the Section Medicinal Chemistry)

Membrane Receptors in Disease: Mechanisms and Targeted Therapeutic Strategies

edited by

Robson Xavier Faria

submission deadline 31 Mar 2026 | Viewed by 41 | Submission Open

Keywords: membrane receptors; targeted drug; signal transduction; therapeutic antibodies; inhibitor; synthetic

(This special issue belongs to the Section Pharmacology)

Bioactive Natural Extracts: Advances in Pharmacological and Therapeutic Research

edited by

Gabriela-Maria Baci

and

Victorița Bonta

submission deadline 1 Apr 2026 | Viewed by 112 | Submission Open

Keywords: bioactive compounds; natural extracts; pharmacological activity; drug discovery; plant-derived compounds

(This special issue belongs to the Section Natural Products)

Advances in Ophthalmic Drug Discovery and Delivery: From Targets to Treatments

edited by

Hongli Wu

submission deadline 10 Apr 2026 | 4 articles | Viewed by 5911 | Submission Open

Keywords: retinal degeneration; glaucoma; cataract; diabetic retinopathy; drug target; drug delivery; drug candidate; gene therapy; stem cells; natural products; Artificial Intelligence

(This special issue belongs to the Section Pharmacology)

Emerging Therapeutics for the Prevention of Chemotherapy-Induced Cardiotoxicity: Advances and Future Perspectives

edited by

Luigi Spadafora

Marco Bernardi

, Sarto Sarto and

Vincenzo Quagliariello

submission deadline 20 Apr 2026 | 3 articles | Viewed by 5075 | Submission Open

Keywords: cardio-oncology; chemotherapy-induced cardiotoxicity; cardioprotective agents; biomarkers; heart failure prevention; precision medicine; pharmacological innovation; molecular targets; cancer survivorship; multidisciplinary care

(This special issue belongs to the Section Pharmacology)

Next-Generation Targeted Therapy: vNARs as Drug Carriers and Intracellular Neutralizing Agents

edited by

Tanya Camacho-Villegas

and

Mirna Burciaga-Flores

submission deadline 20 Apr 2026 | Viewed by 155 | Submission Open

Keywords: vNAR; drug delivery; intrabodies; payload; nanotechnology; immunotoxins; phage display; biopanning; single-domain antibody

(This special issue belongs to the Section Pharmacology)

Targeting Enzymes in Drug Design and Discovery

edited by

Mariyana Atanasova

submission deadline 20 Apr 2026 | Viewed by 122 | Submission Open

Keywords: drug design; computer-aided drug design (CADD); molecular docking; molecular dynamics; QSAR; druggable proteins; synthesis; in vitro and in vivo activity evaluations; ADMET predictions and evaluations

(This special issue belongs to the Section Biopharmaceuticals)

Biosimilars in Oncology: Applications in Pharmaceutics and Pharmaceuticals

edited by Jacopo Giuliani

submission deadline 20 Apr 2026 | Viewed by 8 | Submission Open

Keywords: biosimilars; oncology; randomized controlled trials; pharmacokinetics; pharmacodynamics

(This special issue belongs to the Section Biopharmaceuticals)

Design and Synthesis of Compounds with Potential Anti-Inflammatory Activity

edited by

Aleksandra Redzicka

Beata Tylińska

and Anna Wójcicka

submission deadline 22 Apr 2026 | Viewed by 90 | Submission Open

Keywords: drug design; synthesis; anti-inflammatory activity; cyclooxygenases; lipoxygenases; cytokines; anticancer activity; Alzheimer's disease; neuroinflammation; molecular mechanisms

(This special issue belongs to the Section Medicinal Chemistry)

Advanced Nanosystems and Emerging Therapies: Innovations in Tuberculosis Treatment and Drug Resistance

edited by

Fernando Rogério Pavan

and

Cesar Augusto Roque-Borda

submission deadline 24 Apr 2026 | 2 articles | Viewed by 2862 | Submission Open

Keywords: nanosystems; tuberculosis therapy; drug delivery; multidrug-resistant Mycobacterium tuberculosis (MDR-TB); nanotechnology-based therapeutics

(This special issue belongs to the Section Pharmaceutical Technology)

Use of Encapsulating Polymers of Active Compounds in the Pharmaceutical Industry

edited by Alba Adriana Vallejo-Cardona, Inocencio Higuera-Ciapara and

Janna Douda

submission deadline 24 Apr 2026 | 1 articles | Viewed by 2620 | Submission Open

Keywords: polymer; drug delivery; active compounds; encapsulation; pharmaceutical industry; natural polymers; synthetic polymers

(This special issue belongs to the Section Pharmaceutical Technology)

Medicinal Chemistry of Metal Complexes: Design, Synthesis and Evaluation

edited by

Bojana B. Zmejkovski

Goran Kaluđerović

and

Nebojša Pantelić

submission deadline 24 Apr 2026 | 1 articles | Viewed by 2422 | Submission Open

Keywords: metal complexes; medicinal chemistry; bioinorganic chemistry; coordination chemistry; organometallics; metal-based drugs; biological activity; toxicology; biomedical application; drug delivery

(This special issue belongs to the Section Medicinal Chemistry)

Recent Advances in Psychopharmacology: 2nd Edition

edited by Roos Van Westrhenen and Allan H. Young

submission deadline 24 Apr 2026 | Viewed by 155 | Submission Open

Keywords: psychopharmaca; pharmacogenomics; pharmacogenetics; psychedelics; dementia drugs

(This special issue belongs to the Section Pharmacology)

Targeting Neuromodulators: Effective Therapeutic Strategies for Brain Disorders

edited by

Jana Tchekalarova

submission deadline 24 Apr 2026 | Viewed by 51 | Submission Open

Keywords: neuromodulators; brain disorders; targets; dysfunctional networks; dopamine; serotonin

(This special issue belongs to the Section Pharmacology)

Applications of Beehive Products for Wound Repair and Skin Care

edited by Simona Martinotti

submission deadline 25 Apr 2026 | 3 articles | Viewed by 17786 | Submission Open

Keywords: anti-aging; antibacterial properties; healing properties; honey; propolis; bee venom; wound repair; skin care

(This special issue belongs to the Section Natural Products)

Pharmacology of Antidepressants: Recent Advances

edited by

Anna Wiktorowska-Owczarek

submission deadline 25 Apr 2026 | 4 articles | Viewed by 16015 | Submission Open

Keywords: new mechanisms of antidepressants action; new targets for antidepressant therapy; rapid-acting antidepressants; inflammation in depression; gut– microbiota– brain axis in depression; probiotic as an antidepressant; quo vadis pharmacology of antidepressants

(This special issue belongs to the Section Pharmacology)

New Development in Pharmacotherapy of Kidney Diseases

edited by Chihchao Yang

submission deadline 25 Apr 2026 | 4 articles | Viewed by 8260 | Submission Open

Keywords: chronic kidney disease (CKD); acute kidney injury (AKI); pharmacotherapy; cardiovascular protection; kidney protection; bone health; endocrine function; gut health; metabolism; neuromuscular function; nutrition; symptom management; sodium-glucose cotransporter-2 (SGLT-2) inhibitors; glucagon-like peptide-1 (GLP-1) receptor agonists; non-steroidal mineralocorticoid receptor antagonists (MRA); endothelin receptor antagonists; anemia management; electrolyte abnormalities; dialysis; nephrotoxicity; drug interactions; uremic toxin; clinical trials; innovative therapies; protein-energy wasting; chronic kidney disease and bone mineral disease; inflammation; oxidation; diabetes; hypertension; obesity; hyperlipidemia; pruritus; osteoporosis; fracture; sarcopenia; protein-energy wasting

(This special issue belongs to the Section Pharmacology)

Potential Therapeutic Targets for the Management of Diabetes Mellitus, Obesity and Cancer

edited by Marisa Jádna Silva Frederico and

Fátima Regina Mena Barreto Silva

submission deadline 25 Apr 2026 | 4 articles | Viewed by 6047 | Submission Open

Keywords: diabetes; obesity; cancer; pharmacological targets

(This special issue belongs to the Section Pharmacology)

Fighting Tropical Neglected Diseases with Natural Products: New Approaches Against Ancient Diseases

edited by

Igor Rodrigues

André Luis Souza dos Santos

, Dirlei Nico and Ana Claudia Fernandes Amaral

submission deadline 25 Apr 2026 | 3 articles | Viewed by 5439 | Submission Open

Keywords: plant extracts; natural compounds; neglected diseases; drug resistance; natural product-based formulations; antiparasitic drugs; enzyme inhibition

Computer-Aided Drug Design and Drug Discovery, 2nd Edition

edited by

Dragos Mihai

and

George Mihai Nitulescu

submission deadline 25 Apr 2026 | 5 articles | Viewed by 4259 | Submission Open

Keywords: chemoinformatics; bioinformatics; molecular modeling; virtual screening; molecular docking; quantitative structure– activity relationship (QSAR); pharmacophore modeling; target identification; repurposing; ADME-T prediction

(This special issue belongs to the Section Medicinal Chemistry)

Pharmacovigilance Insights: Addressing Drug Misuse and Enhancing Drug Safety

edited by

Cristina Sofia De Jesus Monteiro

and

Samuel Martins Silvestre

submission deadline 25 Apr 2026 | 1 articles | Viewed by 3760 | Submission Open

Keywords: adverse drug reaction; pharmacovigilance; drug safety; signal detection; risk management

(This special issue belongs to the Section Pharmacology)

Combating Drug Resistance in Cancer

edited by

Nina Rembiałkowska

and

Wojciech Szlasa

submission deadline 25 Apr 2026 | 2 articles | Viewed by 3607 | Submission Open

Keywords: multidrug resistance; cancer cells; cancer drug resistance; overcoming chemoresistance; targeted cancer therapies; novel anti-cancer strategies; tumor resistance mechanisms; innovative cancer treatments; reversing drug resistance

(This special issue belongs to the Section Medicinal Chemistry)

Advances in the Treatment of Leukemia, Lymphomas and Plasma Cell Disorders

edited by

Adriano de Paula Sabino

, Karina Braga Gomes and Maria Das Graças Carvalho

submission deadline 25 Apr 2026 | 2 articles | Viewed by 2347 | Submission Open

Keywords: leukemias; lymphomas; chemotherapy; target therapy; immunotherapy; kinase inhibitors; hematologic oncology; therapy; treatment

(This special issue belongs to the Section Medicinal Chemistry)

Pharmaceutical Approaches to Orofacial Pain and Chronic Pain Conditions

edited by

Takahiko Nagamine

submission deadline 25 Apr 2026 | 1 articles | Viewed by 1869 | Submission Open

Keywords: chronic orofacial pain; pharmaceutical approach; myofascial orofacial pain; temporomandibular joint pain; neurovascular orofacial pain; idiopathic orofacial pain; burning mouth syndrome; persistent idiopathic facial pain; persistent idiopathic dentoalveolar pain; tricyclic antidepressants; serotonin reuptake inhibitors; anticonvulsants

(This special issue belongs to the Section Pharmacology)

QSAR and Chemoinformatics in Drug Design and Discovery

edited by

Elena Cichero

and

Naomi Scarano

submission deadline 25 Apr 2026 | 2 articles | Viewed by 1813 | Submission Open

Keywords: QSAR modeling; machine learning; ligand-based virtual screening and design; computer-aided drug repurposing; computational methods; molecular modeling; molecular dynamics; drug design

(This special issue belongs to the Section Medicinal Chemistry)

Displaying special issue 201-250 on page 5 of 8.

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