Tumor Microenvironment Targeted Nanotherapy
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".
Deadline for manuscript submissions: closed (20 April 2023) | Viewed by 2655
Special Issue Editors
Interests: nanotechnology in the diagnosis and treatment of central nervous system diseases; protein and gene drug carrier; tumor diagnosis and treatment
Interests: biomedical materials for anticancer drug/gene delivery and bio-imaging; design and development of drug delivery systems of antibacterial and antiviral drugs; biosafety chemistry and biosafety materials
Special Issue Information
Dear Colleagues,
Recent findings suggest that the cellular and extracellular materials surrounding cancerous cells in an atypical tumor microenvironment (TME) play a pivotal role in tumor initiation and progression processes. The TME comprises an intricate system involving diverse cell types, including endothelial cells, pericytes, smooth muscle cells, fibroblasts, various inflammatory cells, dendritic cells, and cancer stem cells (CSCs). TME-forming cells dynamically interact with cancerous cells through various signaling mechanisms and pathways. Present-day researchers thus have a particular interest in exploiting these relationships to develop nanotherapeutics. Nanoparticles’ benefits include their ability to passively target through the EPR effect and capacity to be easily be modified with a variety of moieties for active targeting. Moreover, they can utilize the altered tumor environment to promote drug accumulation at tumor sites and modulate the tumor microenvironment by carrying drugs.
This Special Issue welcomes both reviews and original articles shedding light on nanotherapeutics targeting or regulating the tumor microenvironment. Topics of interest include, but are not limited to, the following topics:
- Development of the cancer-specific delivery and accumulation of nanotechnology-based systems bearing anticancer drug and diagnostics.
- Effectively promoting immune stimulation of infiltrating lymphocytes in the TME to exert cancer chemotherapy effects combined with immunotherapy.
- Effectively enhancing the delivery and transfection efficiency of gene drugs to target cells in the TME for precise cancer treatment.
- Research and design of biosafety materials for the tumor microenvironment (pH, hypoxic environment, specific cells involved in TME, etc.) to optimize cancer prevention, treatment, and prognosis.
- Complex coculture systems (stem cells/immune cells/cancer cells) based on advanced nanomaterials.
Dr. Chaoyong Liu
Dr. Haihua Xiao
Guest Editors
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Keywords
- tumor microenvironment
- nanomaterials
- cancer therapy
- diagnosis of cancer
- cancer-specific delivery and accumulation
- drug delivery system
- combination therapy
- therapeutic resistance
- gene therapy
- biosafety materials
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