Pharmaceutical Aspects of Polymer-Based Delivery of Nucleic Acids 2022
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmaceutical Technology".
Deadline for manuscript submissions: closed (31 December 2022) | Viewed by 350
Special Issue Editor
Interests: gene delivery; non-viral strategies; polymeric carriers; and/or transfection efficiency
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The therapeutic potential using nucleic acids (DNA or RNA) has many clinical applications for the treatment of diseases. For reaching the goal, these nucleic acids require vectors with efficacy and efficiency. The use of non-viral carriers, mainly based on cationic polymers which have low or no immunogenicity and are able to transfect a great variety of cells, has received substantial attention. Moreover, these polymers possess the advantages of being versatile in structures, tunable for aims, easy to produce at a large scale with a low cost, and easy to preserve.
This Special Issue focuses on the physicochemical properties as well as the transfection potential of polymer-based nucleic acid formulations (referred as polyplexes). New approaches and different polymeric systems with chemical modifications are introduced, and how these polyplexes tackle the cellular barriers, the cytotoxicity, and low transfection efficiency for a successful expression of delivered genes are demonstrated and discussed. Finally, attention is given to the stabilization of non-viral nucleic acid formulations. In summary, articles in this issue summarize the current developments of types and components of transfection reagents for the optimization of gene delivery. This set of knowledge would benefit the progress to the development of a safe and efficient gene delivery.
Dr. Jong Yuh Cherng
Guest Editor
Manuscript Submission Information
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Keywords
- gene delivery
- non-viral strategies
- polymeric carriers
- transfection efficiency
