Special Issue "Polyethylene Glycol (PEG) and PEGylation in Pharmacy"
A special issue of Pharmaceuticals (ISSN 1424-8247).
Deadline for manuscript submissions: closed (31 July 2018)
Prof. Dr. Peter Turecek
1. Shire, Vienna, Austria;
2. Department of Pharmacology and Toxicology, University of Vienna, Austria;
Website 1 | Website 2 | Website 3 | E-Mail
Interests: protein modification; protein purification and characterization; plasma fractionation; virus inactivation; molecular biology; recombinant proteins; coagulation physiology; biochemical and analytical techniques; diagnostics; pharmaceutical biotechnology; pharmacology and toxicology
Polyethylene glycol (PEG) is a synthetic, highly water soluble, inert polymer that is produced in a wide range of molecular sizes and structures. PEGs of various molecular weights have been widely used in cosmetics, pharmaceuticals and other consumer care products. For the past 20 years, PEG has also been used for the chemical modification of drugs and particularly of biopharmaceuticals, known as PEGylation technology. Over the years, several second-generation biologicals have used PEGylation to provide pharmacologically-improved drug molecules.
There is a clear need to further improve pharmacologic and pharmaceutical properties of biopharmaceuticals to reduce treatment frequency or to allow more convenient routes of administration. As a result of its successful and safe use, many other PEGylated drugs are currently under non-clinical and clinical development. Consequently, we are seeing more PEG derivatives, enhanced PEGylation reagents, and linker and coupling chemistries, and completely new PEGylation approaches. These are applied to essentially all classes of drug molecules, biologicals, such as peptides, proteins, aptamers, and new pharmaceutical formulations and drug delivery systems, such as liposomes and nanospheres. At the same time, PEG continues to be a ubiquitously used polymer with a high exposure to humans.
In this Special Issue, we seek submissions corresponding to all aspects of PEG used in pharmaceutical and medical applications. We call for reports on methods of PEGylation, uses of PEG in various applications, synthesis of PEG derivatives—essentially all preparative work with PEG in pharmacy. Moreover, we will review analytical methods related to PEG and PEG derivatives. Manuscripts dealing with experiences of PEG in formulation and drug delivery are also welcome.
- PEGylation of Biopharmaceuticals: A Review of Chemistry and Nonclinical Safety Information of Approved Drugs. https://www.ncbi.nlm.nih.gov/pubmed/26869412
- Noncovalent PEGylation, An Innovative Subchapter in the Field of Protein Modification. https://www.ncbi.nlm.nih.gov/pubmed/26523632
- Process for protein PEGylation. https://www.ncbi.nlm.nih.gov/pubmed/24531008
- PEGylated Biopharmaceuticals: Current Experience and Considerations for Nonclinical Development. https://www.ncbi.nlm.nih.gov/pubmed/26239651
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access quarterly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 850 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- polyethylene glycol
- PEGylation chemistry