Drug Resistance Against Cancer Treatment
A special issue of Pharmaceuticals (ISSN 1424-8247). This special issue belongs to the section "Pharmacology".
Deadline for manuscript submissions: 20 July 2025 | Viewed by 1904
Special Issue Editor
Interests: pharmaceutics; targeted delivery; RNA interference; cancer biology; signaling pathways
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
In the era when chemotherapy was the only option for “drug” therapy in cancer treatment, multidrug resistance (MDR) was a major hurdle that could suddenly render even the most effective treatments obsolete. In fact, MDR seemed to be so inevitable that it was known as a matter of “when”, rather than a matter of “if”. Chemotherapy is still at the forefront of cancer treatment, even following the introduction of molecularly targeted small molecule drugs, and therefore, the battle with MDR continues. While mechanisms involved in MDR might not apply to molecularly targeted drugs, the resistance to these drugs is also an ever-present threat. However, just like the drug itself, the resistance mechanisms (inherent or acquired) are more specific, often relating to the same signaling pathway that is the target of the drug.
This Special Issue aims to include research and review papers that provide the most recent information and developments on the ongoing battle with resistance against cancer treatment. The scope of the issue is to cover both MDR and resistance against molecularly targeted drugs. Our hope is to bring together a collective wisdom regarding our approach to drug resistance in cancer.
Dr. Hamidreza Montazeri Aliabadi
Guest Editor
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Keywords
- multidrug resistance (MDR)
- chemotherapy
- P-glycoprotein (P-gp)
- ATP-binding cassette (ABC) transporters
- molecularly targeted drugs
- inherent resistance
- acquired resistance
- signaling pathways
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