Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
6.1
4.3
Journals
Pharmaceuticals
Special Issues
Plant-Based Therapies for Circulatory Disorders
share announcement

Plant-Based Therapies for Circulatory Disorders

A special issue of Pharmaceuticals (ISSN 1424-8247).

Deadline for manuscript submissions: closed (30 November 2024) | Viewed by 3675

Special Issue Editor

Dr. Priscila De Souza

E-Mail Website
Guest Editor
Programa de Pós-Graduação em Ciências Farmacêuticas, Núcleo de Investigações Químico-Farmacêuticas (NIQFAR), Universidade do Vale do Itajaí (UNIVALI), Campus Itajaí, Rua Uruguai 458, Itajaí 88302-901, SC, Brazil
Interests: natural products; bioactive compounds; kidney disease; hypertension; cardiovascular disease
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Circulatory disorders are one of the principal reasons for morbidity and mortality worldwide. There are numerous distinct circulatory apparatus diseases that interfere with the complex system responsible for blood delivery around the body. Atherosclerosis, myocardial infarction, cardiac ischemia, heart failure, hypertension, and stroke are examples of diseases that can affect the circulatory system.

Lifestyle changes, including weight loss, a healthy diet, regular exercise, and not smoking, are essential for the treatment and prevention of all circulatory diseases. The choice of drug therapy will differ depending on the type of circulatory disease, according to its associated symptoms. However, despite all this knowledge, the therapeutic options available are not yet sufficient for the control of many patients and their pathologies. Therefore, there is a strong demand for innovative treatment possibilities, the most promising of which are those obtained from medicinal plants, which contain inestimable supplies of metabolites with substantial therapeutic capacity.

This Special Issue will summarize the advantages of the plant-based therapies that have been investigated for circulatory disorders and will introduce potential candidates for innovative therapeutic development.

Dr. Priscila De Souza
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceuticals is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • plant extracts
  • isolated compounds from medicinal plants
  • hypertension
  • dyslipidemia
  • atherosclerosis
  • myocardial infarction
  • cardiac ischemia
  • heart failure
  • stroke
  • kidney disease

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue polices can be found here.

Published Papers (4 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

15 pages, 2540 KiB  
Article
Cardiovascular Effects of a Glycosylated Flavonoids-Rich Leaf Extract from Brazilian Erythroxylum campestre: A Potential Health Bio-Input
by Letícia Henrique Dantas Gomes de Lima, Marcos Willian Francelino Gomes, Thays Siqueira de Sá Curado, Lara Marques Naves, Stefanne Madalena Marques, Marilene Silva Oliveira, John Ihayi Ogbu, Antonio Carlos Severo Menezes, Giuliana Muniz Vila Verde, James Oluwagbamigbe Fajemiroye and Gustavo Rodrigues Pedrino
Pharmaceuticals 2024, 17(11), 1456; https://doi.org/10.3390/ph17111456 - 30 Oct 2024
Viewed by 572
Abstract
Background: Bioactivity assessments of plant-derived products can benefit human and animal health, especially in regions with vast plant diversity. This study focused on chemical and cardiovascular analyses of Erythroxylum campestre A. St. Hil. leaf extracts. Methods: High-performance liquid chromatography, liquid chromatography [...] Read more.
Background: Bioactivity assessments of plant-derived products can benefit human and animal health, especially in regions with vast plant diversity. This study focused on chemical and cardiovascular analyses of Erythroxylum campestre A. St. Hil. leaf extracts. Methods: High-performance liquid chromatography, liquid chromatography coupled with mass spectrometry, and nuclear magnetic resonance spectroscopy were used to elucidate the structures of the flavonoids in E. campestre. The E. campestre methanolic fraction (ECM-ppt-M; at doses of 1, 2, 3, and 6 mg∙kg−1 or vehicle) was administered intravenously to normotensive and spontaneously hypertensive rats (SHRs), and we recorded the mean arterial pressure (MAP), heart rate (HR), renal vascular resistance (RVR), and aortic vascular resistance (AVC). Results: The ECM-ppt-M extract demonstrated significant antihypertensive activity, as evidenced by reductions in MAP, RVR, and AVR, with effects that were particularly pronounced in SHRs. Following the establishment of these cardiovascular effects, phytochemical analysis revealed the presence of glycosylated flavonoids, which are likely contributors to the observed antihypertensive properties of the extract. Conclusions: The notable reductions in MAP and vascular resistance observed with ECM-ppt-M treatment suggest its antihypertensive effect. These findings demonstrate the potential therapeutic value of this extract with regard to the treatment of hypertension. Future studies on ECM may provide a promising therapeutic alternative capable of reducing the risk of toxicity and adverse effects associated with synthetic drugs. Full article
(This article belongs to the Special Issue Plant-Based Therapies for Circulatory Disorders)
►▼ Show Figures

Figure 1

20 pages, 3552 KiB  
Article
Comparison of Cardioprotective Potential of Cannabidiol and β-Adrenergic Stimulation Against Hypoxia/Reoxygenation Injury in Rat Atria and Ventricular Papillary Muscles
by Anna Pędzińska-Betiuk, Ulrich Gergs, Jolanta Weresa, Patryk Remiszewski, Ewa Harasim-Symbor and Barbara Malinowska
Pharmaceuticals 2024, 17(10), 1379; https://doi.org/10.3390/ph17101379 - 16 Oct 2024
Viewed by 768
Abstract
Background: Hypoxia is one of the most significant pathogenic factors in cardiovascular diseases. Preclinical studies suggest that nonpsychoactive cannabidiol (CBD) and β-adrenoceptor stimulation might possess cardioprotective potential against ischemia-reperfusion injury. The current study evaluates the influence of hypoxia-reoxygenation (H/R) on the function of [...] Read more.
Background: Hypoxia is one of the most significant pathogenic factors in cardiovascular diseases. Preclinical studies suggest that nonpsychoactive cannabidiol (CBD) and β-adrenoceptor stimulation might possess cardioprotective potential against ischemia-reperfusion injury. The current study evaluates the influence of hypoxia-reoxygenation (H/R) on the function of atria and ventricular papillary muscles in the presence of CBD and the nonselective β-adrenoceptor agonist isoprenaline (ISO). Methods: The concentration curves for ISO were constructed in the presence of CBD (1 µM) before or after H/R. In chronic experiments (CBD 10 mg/kg, 14 days), the left atria isolated from spontaneously hypertensive (SHR) and their normotensive control (WKY) rats were subjected to H/R following ISO administration. Results: Hypoxia decreased the rate and force of contractions in all compartments. The right atria were the most resistant to hypoxia regardless of prior β-adrenergic stimulation. Previous β-adrenergic stimulation improved recovery in isolated left atria and right (but not left) papillary muscles. Acute (but not chronic) CBD administration increased the effects of ISO in left atria and right (but not left) papillary muscles. Hypertension accelerates left atrial recovery during reoxygenation. Conclusions: H/R directly modifies the function of particular cardiac compartments in a manner dependent on cardiac region and β-adrenergic prestimulation. The moderate direct cardioprotective potential of CBD and β-adrenergic stimulation against H/R is dependent on the cardiac region, and it is less than in the whole heart with preserved coronary flow. In clinical terms, our research expands the existing knowledge about the impact of cannabidiol on cardiac ischemia, the world′s leading cause of death. Full article
(This article belongs to the Special Issue Plant-Based Therapies for Circulatory Disorders)
►▼ Show Figures

Graphical abstract

18 pages, 3650 KiB  
Article
Comparative Analysis of the Protective Effect of Naringenin on Cardiovascular Parameters of Normotensive and Hypertensive Rats Subjected to the Myocardial Infarction Model
by Anelize Dada, Rita de Cássia Vilhena da Silva, Mariana Zanovello, Jeniffer C. Moser, Sabrina L. D. Orengo, Martina O. Cavichiolo, Eleine R. Bidinha, Thaise Boeing, Valdir Cechinel-Filho and Priscila de Souza
Pharmaceuticals 2024, 17(10), 1324; https://doi.org/10.3390/ph17101324 - 4 Oct 2024
Viewed by 881
Abstract
Background: Cardiovascular diseases rank as the top global cause of mortality, particularly acute myocardial infarction (MI). MI arises from the blockage of a coronary artery, which disrupts blood flow and results in tissue death. Among therapeutic approaches, bioactives from medicinal plants emerge as [...] Read more.
Background: Cardiovascular diseases rank as the top global cause of mortality, particularly acute myocardial infarction (MI). MI arises from the blockage of a coronary artery, which disrupts blood flow and results in tissue death. Among therapeutic approaches, bioactives from medicinal plants emerge as promising for the development of new medicines. Objectives: This study explored the effects of naringenin (NAR 100 mg/kg), a flavonoid found in citrus fruits, in normotensive (NTR) and spontaneously hypertensive (SHR) rats, both subjected to isoproterenol (ISO 85 mg/kg)-induced MI. Results: Post-treatment assessments indicated that NAR reduced blood pressure and minimized clot formation, particularly notable in the SHR group, which helps mitigate damage related to hypertension and ISO exposure. Additionally, NAR effectively restored KCl-induced contractility in the aortas of both NTR and SHR groups. NAR treatment reduced reduced glutathione (GSH) and lipid hydroperoxides (LOOH) values and recovered the activity of the antioxidant enzymes catalase (CAT) and glutathione-s-transferase (GST) in NTR groups. Moreover, myocardial damage assessed through histological analyses was reduced in groups treated with NAR. Conclusions: The results highlight significant pathophysiological differences between the groups, suggesting that NAR has protective potential against ISO-induced cardiac damage, warranting further investigation into its protective effects and mechanisms. Full article
(This article belongs to the Special Issue Plant-Based Therapies for Circulatory Disorders)
►▼ Show Figures

Figure 1

16 pages, 32828 KiB  
Article
The Cardioprotective Potential of Herbal Formulas in Myocardial Infarction-Induced Heart Failure through Inhibition of JAK/STAT3 Signaling and Improvement of Cardiac Function
by Youn-Jae Jang, Hye-Yoom Kim, Se-Won Na, Mi-Hyeon Hong, Jung-Joo Yoon, Ho-Sub Lee and Dae-Gill Kang
Pharmaceuticals 2024, 17(9), 1132; https://doi.org/10.3390/ph17091132 - 27 Aug 2024
Cited by 1 | Viewed by 910
Abstract
Myocardial infarction (MI) is a leading cause of heart failure, characterized by adverse cardiac remodeling. This study evaluated the cardioprotective potential of Dohongsamul-tang (DHT), a traditional Korean herbal formula, in a rat model of MI-induced heart failure. Rats underwent left anterior descending (LAD) [...] Read more.
Myocardial infarction (MI) is a leading cause of heart failure, characterized by adverse cardiac remodeling. This study evaluated the cardioprotective potential of Dohongsamul-tang (DHT), a traditional Korean herbal formula, in a rat model of MI-induced heart failure. Rats underwent left anterior descending (LAD) artery ligation and were treated with either 100 mg/kg or 200 mg/kg of DHT daily for 8 weeks. DHT treatment significantly improved cardiac function, as evidenced by increased ejection fraction (EF) from 62.1% to 70.1% (100 mg/kg) and fractional shortening (FS) from 32.3% to 39.4% (200 mg/kg) compared to the MI control group. Additionally, DHT reduced infarct size by approximately 63.3% (from 60.0% to 22.0%) and heart weight by approximately 16.7% (from 3.6 mg/g to 3.0 mg/g), and significantly decreased levels of heart failure biomarkers: LDH was reduced by 37.6% (from 1409.1 U/L to 879.1 U/L) and CK-MB by 47.6% (from 367.3 U/L to 192.5 U/L). Histological analysis revealed a reduction in left ventricle (LV) fibrosis by approximately 50% (from 24.0% to 12.0%). At the molecular level, DHT inhibited the expression of phospho-JAK by 75% (from 2-fold to 0.5-fold), phospho-STAT3 by 30.8% (from 1.3-fold to 0.9-fold), Bax/Bcl-2 by 56.3% (from 3.2-fold to 1.4-fold), and caspase-3 by 46.3% (from 1.23-fold to 0.66-fold). These results suggest that DHT exerts cardioprotective effects by modulating the JAK/STAT3 signaling pathway, highlighting its potential as a therapeutic option for heart failure. Full article
(This article belongs to the Special Issue Plant-Based Therapies for Circulatory Disorders)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-4
Back to TopTop